ID Q8GNY5_STAAU Unreviewed; 213 AA. AC Q8GNY5; DT 01-MAR-2003, integrated into UniProtKB/TrEMBL. DT 01-MAR-2003, sequence version 1. DT 24-JAN-2024, entry version 101. DE SubName: Full=Far1 {ECO:0000313|EMBL:AAN07146.1}; DE SubName: Full=FusB {ECO:0000313|EMBL:AAL12234.1, ECO:0000313|EMBL:CAL23838.1}; DE SubName: Full=Fusidic acid resistance {ECO:0000313|EMBL:ABB82610.1}; GN Name=far1 {ECO:0000313|EMBL:AAN07146.1}; GN Synonyms=fusB {ECO:0000313|EMBL:AAL12234.1}; OS Staphylococcus aureus. OG Plasmid pUB101 {ECO:0000313|EMBL:AAN07146.1}, and OG Plasmid pUB102 {ECO:0000313|EMBL:ABB82610.1}. OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae; OC Staphylococcus. OX NCBI_TaxID=1280 {ECO:0000313|EMBL:AAN07146.1}; RN [1] {ECO:0000313|EMBL:AAN07146.1} RP NUCLEOTIDE SEQUENCE. RC PLASMID=pUB101 {ECO:0000313|EMBL:AAN07146.1}; RX PubMed=12205055; DOI=10.1093/jac/dkf153; RA O'Brien F.G., Price C., Grubb W.B., Gustafson J.E.; RT "Genetic characterization of the fusidic acid and cadmium resistance RT determinants of Staphylococcus aureus plasmid pUB101."; RL J. Antimicrob. Chemother. 50:313-321(2002). RN [2] {ECO:0000313|EMBL:AAN07146.1} RP NUCLEOTIDE SEQUENCE. RC PLASMID=pUB101 {ECO:0000313|EMBL:AAN07146.1}; RA O'Brien F.G., Grubb W.B., Gustafson J.E.; RT "The complete sequence of the Staphylococcus aureus beta-lactamase-fusidic RT acid resistance plasmid pUB101."; RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:ABB82610.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=DD04V16073 {ECO:0000313|EMBL:ABB82610.1}; RC PLASMID=pUB102 {ECO:0000313|EMBL:ABB82610.1}; RX PubMed=16842566; DOI=10.1111/j.1469-0691.2006.01420.x; RA Monecke S., Slickers P., Hotzel H., Richter-Huhn G., Pohle M., Weber S., RA Witte W., Ehricht R.; RT "Microarray-based characterisation of a Panton-Valentine leukocidin- RT positive community-acquired strain of methicillin-resistant Staphylococcus RT aureus."; RL Clin. Microbiol. Infect. 12:718-728(2006). RN [4] {ECO:0000313|EMBL:AAL12234.1} RP NUCLEOTIDE SEQUENCE. RC PLASMID=pUB101 {ECO:0000313|EMBL:AAL12234.1}; RX PubMed=16390458; DOI=10.1111/j.1365-2958.2005.04971.x; RA O'Neill A.J., Chopra I.; RT "Molecular basis of fusB-mediated resistance to fusidic acid in RT Staphylococcus aureus."; RL Mol. Microbiol. 59:664-676(2006). RN [5] {ECO:0000313|EMBL:CAL23838.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CS6 {ECO:0000313|EMBL:CAL23838.1}; RX PubMed=17344365; DOI=10.1128/JCM.01984-06; RA O'Neill A.J., Larsen A.R., Skov R., Henriksen A.S., Chopra I.; RT "Characterization of the epidemic European fusidic acid-resistant impetigo RT clone of Staphylococcus aureus."; RL J. Clin. Microbiol. 45:1505-1510(2007). RN [6] {ECO:0007829|PDB:4ADN, ECO:0007829|PDB:4ADO} RP X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) IN COMPLEX WITH ZINC. RX PubMed=22645663; DOI=10.1098/RSOB.120016; RA Guo X., Peisker K., Backbro K., Chen Y., Koripella R.K., Mandava C.S., RA Sanyal S., Selmer M.; RT "Structure and function of FusB: an elongation factor G-binding fusidic RT acid resistance protein active in ribosomal translocation and recycling."; RL Open Biol. 2:120016-120016(2012). RN [7] {ECO:0007829|PDB:4E4B} RP X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) IN COMPLEX WITH ZINC. RA Cox G., Edwards T.A., O'Neill A.J.; RT "Investigating the FusB:EF-G interface."; RL Submitted (MAR-2012) to the PDB data bank. RN [8] {ECO:0007829|PDB:2MZW} RP STRUCTURE BY NMR IN COMPLEX WITH ZINC. RX PubMed=26781961; DOI=10.1038/srep19524; RA Tomlinson J.H., Thompson G.S., Kalverda A.P., Zhuravleva A., O'Neill A.J.; RT "A target-protection mechanism of antibiotic resistance at atomic RT resolution: insights into FusB-type fusidic acid resistance."; RL Sci. Rep. 6:19524-19524(2016). CC -!- INTERACTION: CC Q8GNY5; Q2G0N1: fusA; Xeno; NbExp=3; IntAct=EBI-16223542, EBI-16223558; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY047358; AAL12234.1; -; Genomic_DNA. DR EMBL; AY373761; AAN07146.1; -; Genomic_DNA. DR EMBL; DQ269019; ABB82610.1; -; Genomic_DNA. DR EMBL; AM292600; CAL23838.1; -; Genomic_DNA. DR RefSeq; NP_932197.1; NC_005127.1. DR RefSeq; WP_000855537.1; NZ_WBTS01000039.1. DR PDB; 2MZW; NMR; -; B=1-213. DR PDB; 4ADN; X-ray; 1.65 A; A/B=1-213. DR PDB; 4ADO; X-ray; 2.30 A; A/B=1-213. DR PDB; 4E4B; X-ray; 2.80 A; A=1-213. DR PDBsum; 2MZW; -. DR PDBsum; 4ADN; -. DR PDBsum; 4ADO; -. DR PDBsum; 4E4B; -. DR AlphaFoldDB; Q8GNY5; -. DR SMR; Q8GNY5; -. DR DIP; DIP-60010N; -. DR IntAct; Q8GNY5; 1. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR CDD; cd16342; FusC_FusB; 1. DR Gene3D; 1.20.1280.250; -; 1. DR InterPro; IPR032330; EF-G-binding_C. DR InterPro; IPR010841; EF-G-binding_N. DR InterPro; IPR038344; EF-G_N_sf. DR Pfam; PF07299; EF-G-binding_N; 1. DR Pfam; PF16571; FBP_C; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:2MZW, ECO:0007829|PDB:4ADN}; KW Metal-binding {ECO:0007829|PDB:4ADN, ECO:0007829|PDB:4ADO}; KW Plasmid {ECO:0000313|EMBL:AAN07146.1}; KW Zinc {ECO:0007829|PDB:4ADN, ECO:0007829|PDB:4ADO}. FT DOMAIN 4..87 FT /note="Elongation factor G-binding protein N-terminal" FT /evidence="ECO:0000259|Pfam:PF07299" FT DOMAIN 100..199 FT /note="Elongation factor G-binding protein C-terminal FT treble-clef zinc-finger" FT /evidence="ECO:0000259|Pfam:PF16571" FT BINDING 157 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0007829|PDB:4ADN, ECO:0007829|PDB:4ADO" FT BINDING 160 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0007829|PDB:4ADN, ECO:0007829|PDB:4ADO" FT BINDING 189 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0007829|PDB:4ADN, ECO:0007829|PDB:4ADO" FT BINDING 195 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0007829|PDB:4ADN, ECO:0007829|PDB:4ADO" SQ SEQUENCE 213 AA; 25188 MW; 4171C35EEAEA74B6 CRC64; MKTMIYPHQY NYIRSVILRL KNVYKTVNDK ETVKVIQSET YNDINEIFGH IDDDIEESLK VLMNIRLSNK EIEAILNKFL EYVVPFELPS PQKLQKVFKK VKKIKIPQFE EYDLKVSSFV GWNELASNRK YIIYYDEKKQ LKGLYGEISN QVVKGFCTIC NKESNVSLFM KKSKTNSDGQ YVKKGDYICR DSIHCNKQLT DINQFYNFID KLD //