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Q8GNS3 (FEOB_LEGPN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrous iron transport protein B
Gene names
Name:feoB
OrganismLegionella pneumophila
Taxonomic identifier446 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length751 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Fe2+ uptake system, probably driven by GTP. Seems to be required for optimal intracellular infection of macrophages, to be important for growth and/or survival in iron-restricted amoebae. It also plays a key role in extracellular growth under iron-limited conditions. Ref.1

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity.

Induction

Iron uptake is repressed by the global regulator Fur By similarity.

Sequence similarities

Belongs to the FeoB (TC 9.A.8) family. [View classification]

Contains 1 G (guanine nucleotide-binding) domain.

Ontologies

Keywords
   Biological processIon transport
Iron transport
Transport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandGTP-binding
Iron
Nucleotide-binding
   Technical term3D-structure
Gene Ontology (GO)
   Biological_processiron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ferrous iron transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 751751Ferrous iron transport protein B
PRO_0000210832

Regions

Transmembrane276 – 29621Helical; Potential
Transmembrane317 – 33721Helical; Potential
Transmembrane341 – 36121Helical; Potential
Transmembrane385 – 40521Helical; Potential
Transmembrane422 – 44221Helical; Potential
Transmembrane447 – 46721Helical; Potential
Transmembrane512 – 53221Helical; Potential
Transmembrane539 – 55921Helical; Potential
Transmembrane657 – 67721Helical; Potential
Transmembrane685 – 70521Helical; Potential
Transmembrane715 – 73521Helical; Potential
Domain13 – 118106G
Nucleotide binding8 – 158GTP Potential
Nucleotide binding33 – 386GTP Potential
Nucleotide binding54 – 574GTP Potential
Nucleotide binding89 – 924GTP Potential
Nucleotide binding118 – 1214GTP Potential
Nucleotide binding380 – 3878GTP Potential

Secondary structure

1 ..................................... 751
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8GNS3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 46DB2FD7C9986192

FASTA75182,514
        10         20         30         40         50         60 
MTHALLIGNP NCGKTTLFNA LTNANQRVGN WPGVTVEKKT GEFLLGEHLI EITDLPGVYS 

        70         80         90        100        110        120 
LVANAEGISQ DEQIAAQSVI DLEYDCIINV IDACHLERHL YLTSQLFELG KPVVVALNMM 

       130        140        150        160        170        180 
DIAEHRGISI DTEKLESLLG CSVIPIQAHK NIGIPALQQS LLHCSQKIKP LKLSLSVAAQ 

       190        200        210        220        230        240 
QILNDLENQL ISKGYKNSFA YYFSRRLAEG DTLIGEKAFT ESLLIKLQET EQNLDVLLAD 

       250        260        270        280        290        300 
ARYQKIHEIV TLVQKKHSDA SEHFTAKLDK LVLHRFLALP IFFAMMYLMF LFAINIGGAF 

       310        320        330        340        350        360 
QDFFDISTET IFVQGSGWLL QQLHAPNWVI ALVANGVGKG INTTITFIPV IAAMFFFLSL 

       370        380        390        400        410        420 
LETSGYMARA AFVVDKAMRA MGLPGKSFVP MIVGFGCNVP AIMAARTLDS ERDRLLTVMM 

       430        440        450        460        470        480 
SPFMSCSARL AIYAVFVAAF FPSGGHNVVF SLYLIGILMA VFTGYILRKT TLKGHASPLI 

       490        500        510        520        530        540 
LELPAYHRPS LRRLLRETSL RLRFFVYRAG KLIIPICVIL GGLNAITWGG GISSGEANTD 

       550        560        570        580        590        600 
SLLSIIGQWI TPLFAPMGIH QDNWPATVGL LTGMLAKEVV VGTLNSLYAQ VGHVGEITAA 

       610        620        630        640        650        660 
HFDFWGGIKA AFGSIPANLS ELGSALWNPV SASAADSELS QSVYGIMSRR FDGAVGAYAY 

       670        680        690        700        710        720 
LLFVLLYIPC VSTMAVIRQE ANKRFMWTSI VWSFVVAYAT SVVFYQGAKF LDHPQQSMVW 

       730        740        750 
ILAMSLSLLF VLAVFRYSQY GMGRQNAAAN T

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References

[1]"Legionella pneumophila feoAB promotes ferrous iron uptake and intracellular infection."
Robey M., Cianciotto N.P.
Infect. Immun. 70:5659-5669(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
Strain: 130b / Wadsworth / Serogroup 1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF492466 Genomic DNA. Translation: AAN17185.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3IBYX-ray2.50A/B/C/D1-256[»]
ProteinModelPortalQ8GNS3.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR003373. Fe2_transport_prot-B.
IPR011640. Fe2_transport_prot_B_C.
IPR006073. GTP_binding_domain.
IPR011642. Nucleoside_recog_Gate.
[Graphical view]
PfamPF07664. FeoB_C. 1 hit.
PF07670. Gate. 2 hits.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PRINTSPR00326. GTP1OBG.
TIGRFAMsTIGR00437. feoB. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ8GNS3.

Entry information

Entry nameFEOB_LEGPN
AccessionPrimary (citable) accession number: Q8GNS3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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