Q8GND4 (OTCC_STRGC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase, catabolic
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	arcB
Ordered Locus Names:	SGO_1592

Organism

Streptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288) [Complete proteome] [HAMAP]

Taxonomic identifier

29390 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Ornithine carbamoyltransferase, catabolic HAMAP MF_01109		PRO_0000113032
Regions
	Region	58 – 62	5	Carbamoyl phosphate binding By similarity
	Region	272 – 275	4	Ornithine binding By similarity
Sites
	Binding site	109	1	Carbamoyl phosphate By similarity
	Binding site	136	1	Carbamoyl phosphate By similarity
	Site	33	1	Important for structural integrity By similarity
	Site	149	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8GND4 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 906B5DB29AA7C3CA	FASTA	338	37,923
	10 20 30 40 50 60 MTNSVFQGRS FLAEKDFTRA ELEYLIGLSA HLKDLKKRNI EHRYLAGKNI ALLFEKTSTR 70 80 90 100 110 120 TRAAFTTAAI DLGAHPEYLG ANDIQLGKKE STEDTAKVLG RMFDGIEFRG FSQRMVEELA 130 140 150 160 170 180 EFSGVPVWNG LTDEWHPTQM LADYLTVQEN FGRLEGLTLV YCGDGRNNVA NSLLVTGAIL 190 200 210 220 230 240 GVNVHIFSPK ELFPEQEIVE LAEGFAKESG AHILITEDAD EAVKGADVLY TDVWVSMGEE 250 260 270 280 290 300 DKFAERVALL KPYQVNMDLV KKADNEDLIF LHCLPAFHDT NTVYGKDVAE KFGVEEMEVT 310 320 330 DEVFRSKYAR HFDQAENRMH TIKAVMAATL GNLYIPKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and molecular analysis of the gene cluster for the arginine deiminase system from Streptococcus gordonii DL1." Dong Y., Chen Y.-Y.M., Snyder J.A., Burne R.A. Appl. Environ. Microbiol. 68:5549-5553(2002) [PubMed: 12406748] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide." Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R. J. Bacteriol. 189:7799-7807(2007) [PubMed: 17720781] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Challis / ATCC 35105 / CH1 / DL1 / V288.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF534569 Genomic DNA. Translation: AAN65256.1. CP000725 Genomic DNA. Translation: ABV10699.1.
RefSeq	YP_001450870.1. NC_009785.1.
3D structure databases
ProteinModelPortal	Q8GND4.
SMR	Q8GND4. Positions 5-333.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000010443; EBSTRP00000010000; EBSTRG00000010443.
GeneID	5598638.
GenomeReviews	Gene locus SGO_1592 in contig CP000725_GR.
KEGG	sgo:SGO_1592.
PATRIC	19661132. VBIStrGor124371_1567.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027080.
HOGENOM	HBG579429.
OMA	VRICTPE.
ProtClustDB	PRK02102.
Enzyme and pathway databases
BioCyc	SGOR29390:SGO_1592-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
KO	K00611.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC_STRGC

Accession

Primary (citable) accession number: Q8GND4
Secondary accession number(s): A8AYL0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program