Q8GMZ8 (Q8GMZ8_ENTFC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Hyaluronidase EMBL ADO66963.1

Submitted name:
Putative glycoside hydrolase EMBL ADI24170.1
Submitted name:
Putative hyaluronidase EMBL AAN34803.1

Gene names

Name:	hyl EMBL AAN34803.1
Synonyms:	hylEfm EMBL ADI24170.1
ORF Names:	pLG1-0209 EMBL ADO66963.1

Encoded on

Plasmid unnamed Ref.2 EMBL ADI24170.1
Plasmid pLG1 Ref.3 EMBL ADO66963.1

Organism

Enterococcus faecium (Streptococcus faecium) EMBL AAN34803.1

Taxonomic identifier

1352 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Enterococcaceae › Enterococcus

Protein attributes

Sequence length	553 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Molecular function	Hydrolase EMBL ADI24170.1
Technical term	Plasmid EMBL ADI24170.1
Gene Ontology (GO)
Molecular function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8GMZ8 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: F78CF840AFAD5EB8	FASTA	553	65,055
	10 20 30 40 50 60 MKETKINQVK KKLSRYQEVV YRNHCLKWSK NKLNVRFNGL FYRFEQLEEV WKPVTNFQSC 70 80 90 100 110 120 PVQLINDPKE TYDLCITHLY NQHLKNDGFY LKVTNDNQLT IESANLRGFQ YAMEALLESF 130 140 150 160 170 180 FSVGDQLLLP ELILKHEPSV KIRGIIEGFY GIPWTHEMRL SLFSYMKDNQ LNTFMYAPKD 190 200 210 220 230 240 DELLRKKWRE LYDAQELDKF KELLSAAEAS NIDFWYLISP GNDIDITCEE DIQVLLKKLE 250 260 270 280 290 300 QLIELGVFQF GLLMDDIDYQ LKGAAKRRFR EPAFAHAYLV NRVEEYLSTR LSNHELVICP 310 320 330 340 350 360 TEYDNRHGSR YLATLSQEIP EQLPFFWTGP STLAASISTE ELQEMASVYQ RPMLIWDNIP 370 380 390 400 410 420 VNDYLEDKEL LFMSPYENRT PNLSKERYQV TGVVSNPMAQ LEASKFTINS MANYLWNCER 430 440 450 460 470 480 FDPLETWTSV VEKVVGSKLQ PAYLTLTNAF PNHYTSSLLS DEELLLAKDP EWVTKEMAAL 490 500 510 520 530 540 VQAVKWIQQE QHTSRLRTEL EPWLQAITES WTFWQEWQLK KDPKEAEEWL AKKKTHRIGR 550 DLVTAHLEQI IKS

References

[1]	"A potential virulence gene, hylEfm, predominates in Enterococcus faecium of clinical origin." Rice L.B., Carias L., Rudin S., Vael C., Goossens H., Konstabel C., Klare I., Nallapareddy S.R., Huang W., Murray B.E. J. Infect. Dis. 187:508-512(2003) [PubMed: 12552437] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: CV133 EMBL AAN34803.1.
[2]	"Global spread of the hyl(Efm) colonization-virulence gene in megaplasmids of the Enterococcus faecium CC17 polyclonal subcluster." Freitas A.R., Tedim A.P., Novais C., Ruiz-Garbajosa P., Werner G., Laverde-Gomez J.A., Canton R., Peixe L., Baquero F., Coque T.M. Antimicrob. Agents Chemother. 54:2660-2665(2010) [PubMed: 20385861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 15/02 EMBL ADI24174.1, E1438 EMBL ADI24171.1, Ef80 EMBL ADI24170.1, Efm42 EMBL ADI24172.1 and Efm49 EMBL ADI24173.1.
[3]	"A multiresistance megaplasmid pLG1 bearing a hylEfm genomic island in hospital Enterococcus faecium isolates." Laverde Gomez J.A., van Schaik W., Freitas A.R., Coque T.M., Weaver K.E., Francia M.V., Witte W., Werner G. Int. J. Med. Microbiol. 301:165-175(2011) [PubMed: 20951641] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 64/3xUW2774 EMBL ADO66963.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF544400 Genomic DNA. Translation: AAN34803.1. HM043740 Genomic DNA. Translation: ADI24170.1. HM043741 Genomic DNA. Translation: ADI24171.1. HM043742 Genomic DNA. Translation: ADI24172.1. HM043743 Genomic DNA. Translation: ADI24173.1. HM043744 Genomic DNA. Translation: ADI24174.1. HM565216 Genomic DNA. Translation: ADO66963.1.
3D structure databases
ProteinModelPortal	Q8GMZ8.
ModBase	Search...
Protein family/group databases
CAZy	GH84. Glycoside Hydrolase Family 84.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR011496. Beta-N-acetylglucosaminidase. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Pfam	PF07555. NAGidase. 1 hit. [Graphical view]
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q8GMZ8_ENTFC

Accession

Primary (citable) accession number: Q8GMZ8

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	October 19, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)