ID   Q8GMG4_STRGL            Unreviewed;       140 AA.
AC   Q8GMG4;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   24-JAN-2024, entry version 61.
DE   RecName: Full=DUF4440 domain-containing protein {ECO:0000259|Pfam:PF14534};
OS   Streptomyces globisporus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1908 {ECO:0000313|EMBL:AAL06676.1};
RN   [1] {ECO:0000313|EMBL:AAL06676.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C-1027 {ECO:0000313|EMBL:AAL06676.1};
RX   PubMed=12183628; DOI=10.1126/science.1072110;
RA   Liu W., Christenson S.D., Standage S., Shen B.;
RT   "Biosynthesis of the enediyne antitumor antibiotic C-1027.";
RL   Science 297:1170-1173(2002).
RN   [2] {ECO:0007829|PDB:4I4K}
RP   X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS).
RX   PubMed=27406907; DOI=10.1038/ja.2016.88;
RA   Huang T., Chang C.Y., Lohman J.R., Rudolf J.D., Kim Y., Chang C., Yang D.,
RA   Ma M., Yan X., Crnovcic I., Bigelow L., Clancy S., Bingman C.A.,
RA   Yennamalli R.M., Babnigg G., Joachimiak A., Phillips G.N., Shen B.;
RT   "Crystal structure of SgcJ, an NTF2-like superfamily protein involved in
RT   biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027.";
RL   J. Antibiot. 69:731-740(2016).
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DR   EMBL; AY048670; AAL06676.1; -; Genomic_DNA.
DR   RefSeq; WP_010056287.1; NZ_CP029362.1.
DR   PDB; 4I4K; X-ray; 1.70 A; A/B=1-140.
DR   PDBsum; 4I4K; -.
DR   AlphaFoldDB; Q8GMG4; -.
DR   SMR; Q8GMG4; -.
DR   Gene3D; 3.10.450.50; -; 1.
DR   InterPro; IPR027843; DUF4440.
DR   InterPro; IPR032710; NTF2-like_dom_sf.
DR   InterPro; IPR011944; Steroid_delta5-4_isomerase.
DR   NCBIfam; TIGR02246; SgcJ/EcaC family oxidoreductase; 1.
DR   Pfam; PF14534; DUF4440; 1.
DR   SUPFAM; SSF54427; NTF2-like; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4I4K}.
FT   DOMAIN          19..129
FT                   /note="DUF4440"
FT                   /evidence="ECO:0000259|Pfam:PF14534"
SQ   SEQUENCE   140 AA;  14579 MW;  777649C81143D1ED CRC64;
     MTSTDSTTSA PDAALAAVAA LPARIVAAWA DHDADRFADV FAEDGTMILP GLFRKGRENI
     RTHMAAAFAG PYKGTRVIGS PIDARLLGDG IALLITEGGI LAPGETEASG DGAVRASWLA
     VEQDGQWRLA AYQNSPRGND
//