Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8GJM0

- HIS4_SYNE7

UniProt

Q8GJM0 - HIS4_SYNE7

Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene

hisA

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 2 (18 Apr 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei8 – 81Proton acceptorUniRule annotation
    Active sitei129 – 1291Proton donorUniRule annotation

    GO - Molecular functioni

    1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Enzyme and pathway databases

    BioCyciSYNEL:SYNPCC7942_1829-MONOMER.
    UniPathwayiUPA00031; UER00009.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseUniRule annotation (EC:5.3.1.16UniRule annotation)
    Alternative name(s):
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomeraseUniRule annotation
    Gene namesi
    Name:hisAUniRule annotation
    Ordered Locus Names:Synpcc7942_1829
    ORF Names:sen0020
    OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
    Taxonomic identifieri1140 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000002717: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2562561-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerasePRO_0000142064Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi1140.Synpcc7942_1829.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8GJM0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HisA/HisF family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0106.
    HOGENOMiHOG000224614.
    KOiK01814.
    OrthoDBiEOG6H1Q3W.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01014. HisA.
    InterProiIPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR006063. HisA.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00977. His_biosynth. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR00007. TIGR00007. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8GJM0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVIPAIDLL GGQCVRLFQG DYDQAEVYGK DPVGMALRWA EAGAQRLHLV    50
    DLDGAKEGSP VNAEAIATIA QRLSIPVQVG GGLRDRDTVA RLLDSGVERA 100
    ILGTVAVERP ALVEALAGEF PGQIAVGIDA RSGKVATRGW LEDSGLTAVA 150
    LAQQMADLGA CALICTDIGR DGTLQGPNLE ELRAIAAAVS IPVIASGGVG 200
    SLTDLLSLLP LEAQGVSGVI VGKALYTGAV DLQEALRAIG SGRWQDVAVD 250
    DSSRLA 256
    Length:256
    Mass (Da):26,326
    Last modified:April 18, 2006 - v2
    Checksum:i368F941D8BA49AA7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti138 – 1458RGWLEDSG → GAAGRFW in AAN46174. 1 PublicationCurated
    Sequence conflicti152 – 17524AQQMA…DGTLQ → HSRWQTWRLRTDLHRHWARW HAS in AAN46174. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti225 – 2251L → F in AAN46174. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY157498 Genomic DNA. Translation: AAN46174.1.
    CP000100 Genomic DNA. Translation: ABB57859.1.
    RefSeqiYP_400846.1. NC_007604.1.

    Genome annotation databases

    EnsemblBacteriaiABB57859; ABB57859; Synpcc7942_1829.
    GeneIDi3774404.
    KEGGisyf:Synpcc7942_1829.
    PATRICi23789089. VBISynElo51371_2068.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY157498 Genomic DNA. Translation: AAN46174.1 .
    CP000100 Genomic DNA. Translation: ABB57859.1 .
    RefSeqi YP_400846.1. NC_007604.1.

    3D structure databases

    ProteinModelPortali Q8GJM0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1140.Synpcc7942_1829.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB57859 ; ABB57859 ; Synpcc7942_1829 .
    GeneIDi 3774404.
    KEGGi syf:Synpcc7942_1829.
    PATRICi 23789089. VBISynElo51371_2068.

    Phylogenomic databases

    eggNOGi COG0106.
    HOGENOMi HOG000224614.
    KOi K01814.
    OrthoDBi EOG6H1Q3W.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00009 .
    BioCyci SYNEL:SYNPCC7942_1829-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01014. HisA.
    InterProi IPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR006063. HisA.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00977. His_biosynth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR00007. TIGR00007. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Synechococcus elongatus PCC7942 cosmid 4G8."
      Holtman C.K., Sandoval P., Chen Y., Socias T., McMurtry S., Gonzalez A., Salinas I., Golden S.S., Youderian P.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7942.

    Entry informationi

    Entry nameiHIS4_SYNE7
    AccessioniPrimary (citable) accession number: Q8GJM0
    Secondary accession number(s): Q31M60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2003
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 79 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3