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Protein

dTDP-glucose 4,6-dehydratase

Gene

rmlB

Organism
Streptococcus suis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O.UniRule annotation

Cofactori

NAD+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei101NADCombined sources1
Binding sitei161NADCombined sources1
Binding sitei165NADCombined sources1
Binding sitei191NAD; via amide nitrogenCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 16NADCombined sources3
Nucleotide bindingi37 – 40NADCombined sources4
Nucleotide bindingi62 – 63NADCombined sources2
Nucleotide bindingi82 – 86NADCombined sources5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
LigandNADCombined sources, Nucleotide-bindingCombined sources

Names & Taxonomyi

Protein namesi
Recommended name:
dTDP-glucose 4,6-dehydrataseUniRule annotation (EC:4.2.1.46UniRule annotation)
Gene namesi
Name:rmlBImported
ORF Names:A6M16_03315Imported, APQ97_03200Imported, ERS132370_01395Imported, ERS132374_01253Imported, ERS132410_01682Imported, ERS132414_00580Imported, ERS132421_00412Imported, ERS132431_00441Imported, ERS132440_01438Imported, ERS132444_01827Imported, ERS132457_01850Imported, ERS132458_00971Imported, ERS132461_00211Imported, ERS132462_01604Imported, ERS132502_01610Imported, ERS132531_00495Imported, ERS132536_02274Imported
OrganismiStreptococcus suisImported
Taxonomic identifieri1307 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000074903 Componenti: Unassembled WGS sequence
  • UP000072933 Componenti: Unassembled WGS sequence
  • UP000072794 Componenti: Unassembled WGS sequence
  • UP000075182 Componenti: Unassembled WGS sequence
  • UP000072147 Componenti: Unassembled WGS sequence
  • UP000073200 Componenti: Unassembled WGS sequence
  • UP000077401 Componenti: Chromosome
  • UP000074825 Componenti: Unassembled WGS sequence
  • UP000071533 Componenti: Unassembled WGS sequence
  • UP000072226 Componenti: Unassembled WGS sequence
  • UP000070276 Componenti: Chromosome
  • UP000072711 Componenti: Unassembled WGS sequence
  • UP000069831 Componenti: Unassembled WGS sequence
  • UP000073485 Componenti: Unassembled WGS sequence
  • UP000074356 Componenti: Unassembled WGS sequence
  • UP000072003 Componenti: Unassembled WGS sequence
  • UP000073388 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KEPX-ray1.80A/B1-348[»]
1KERX-ray2.20A/B1-348[»]
1OC2X-ray1.50A/B1-348[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8GIP9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 318NAD(P)-bd_domInterPro annotationAdd BLAST311

Sequence similaritiesi

Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1B. Bacteria.
COG1088. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR005888. dTDP_Gluc_deHydtase.
IPR016040. NAD(P)-bd_dom.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF16363. GDP_Man_Dehyd. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01181. dTDP_gluc_dehyt. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8GIP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQFKNIIVT GGAGFIGSNF VHYVYNNHPD VHVTVLDKLT YAGNKANLEA
60 70 80 90 100
ILGDRVELVV GDIADAELVD KLAAKADAIV HYAAESHNDN SLNDPSPFIH
110 120 130 140 150
TNFIGTYTLL EAARKYDIRF HHVSTDEVYG DLPLREDLPG HGEGPGEKFT
160 170 180 190 200
AETNYNPSSP YSSTKAASDL IVKAWVRSFG VKATISNCSN NYGPYQHIEK
210 220 230 240 250
FIPRQITNIL AGIKPKLYGE GKNVRDWIHT NDHSTGVWAI LTKGRMGETY
260 270 280 290 300
LIGADGEKNN KEVLELILEK MGQPKDAYDH VTDRAGHDLR YAIDASKLRD
310 320 330 340
ELGWTPQFTD FSQGLEETIQ WYTDNQDWWK AEKEAVEANY AKTQEVIK
Length:348
Mass (Da):38,932
Last modified:March 1, 2003 - v1
Checksum:iEEA3464D7CBCF2A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP012911 Genomic DNA. Translation: AML46114.1.
CP015557 Genomic DNA. Translation: ANC99563.1.
AJ509828 Genomic DNA. Translation: CAD49092.1.
FIFN01000018 Genomic DNA. Translation: CYU24363.1.
FIFP01000015 Genomic DNA. Translation: CYU37597.1.
FIHA01000008 Genomic DNA. Translation: CYU70721.1.
FIHG01000001 Genomic DNA. Translation: CYU72753.1.
FIGO01000010 Genomic DNA. Translation: CYV01660.1.
FIHS01000004 Genomic DNA. Translation: CYV28548.1.
FIIX01000003 Genomic DNA. Translation: CYV61795.1.
FIIB01000011 Genomic DNA. Translation: CYV67502.1.
FIIS01000008 Genomic DNA. Translation: CYV81693.1.
FIIF01000015 Genomic DNA. Translation: CYV94350.1.
FIID01000015 Genomic DNA. Translation: CYV94732.1.
FIIR01000027 Genomic DNA. Translation: CYW07796.1.
FIKN01000012 Genomic DNA. Translation: CYW95377.1.
FILX01000005 Genomic DNA. Translation: CYX42215.1.
FIMD01000036 Genomic DNA. Translation: CYY02939.1.
RefSeqiWP_002937117.1. NZ_MNPY01000004.1.

Genome annotation databases

EnsemblBacteriaiAML46114; AML46114; APQ97_03200.
ANC99563; ANC99563; A6M16_03315.
CYU24363; CYU24363; ERS132462_01604.
CYU37597; CYU37597; ERS132374_01253.
CYU70721; CYU70721; ERS132414_00580.
CYU72753; CYU72753; ERS132421_00412.
CYV01660; CYV01660; ERS132410_01682.
CYV28548; CYV28548; ERS132431_00441.
CYV61795; CYV61795; ERS132461_00211.
CYV67502; CYV67502; ERS132440_01438.
CYV81693; CYV81693; ERS132458_00971.
CYV94350; CYV94350; ERS132444_01827.
CYV94732; CYV94732; ERS132370_01395.
CYW07796; CYW07796; ERS132457_01850.
CYW95377; CYW95377; ERS132502_01610.
CYX42215; CYX42215; ERS132531_00495.
CYY02939; CYY02939; ERS132536_02274.
PATRICifig|1307.1317.peg.1749.

Similar proteinsi

Entry informationi

Entry nameiQ8GIP9_STRSU
AccessioniPrimary (citable) accession number: Q8GIP9
Secondary accession number(s): F4EEB1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported