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Q8GGP1

- Q8GGP1_STRAZ

UniProt

Q8GGP1 - Q8GGP1_STRAZ

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Protein
Submitted name:

Conserved hypthetical protein

Gene

LnmK

Organism
Streptomyces atroolivaceus
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei65 – 651CoenzymeA; via amide nitrogen and carbonyl oxygenImported
Binding sitei140 – 1401CoenzymeAImported

Names & Taxonomyi

Protein namesi
Submitted name:
Conserved hypthetical proteinImported
Gene namesi
Name:LnmKImported
OrganismiStreptomyces atroolivaceusImported
Taxonomic identifieri66869 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HZNX-ray2.25A1-319[»]
4HZOX-ray1.76A2-319[»]
4HZPX-ray1.77A2-319[»]
ProteinModelPortaliQ8GGP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni260 – 2634CoenzymeA bindingImported

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
InterProiIPR029069. HotDog_dom.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8GGP1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTITSSLDVR PEIKQAVTVR PGMCGPGSLF VGQLGDWTWE TVSAQCDTDV
60 70 80 90 100
FAARDASGNP TYLAFYYFRV RGGRELHPGS LTFGDRLTVT SGCYDQGTES
110 120 130 140 150
VLTLHRIDRA GSDDAQRPLD LHEFYERPRD GSLYVENFNR WVTRSAPGSN
160 170 180 190 200
EDLVKSSPPG FRNDGLPQLP AAYSPRAVYR EARTAHTFRA LDEPGFRLLP
210 220 230 240 250
DTVEVEHPVD IVRDVNGVGL LYFASYFSMV DKAALALWRR LGRSDRAFLR
260 270 280 290 300
RVVVDQQMCY LGNADLDSVL TLGARVRVST ETPGEELVDV VISDRDSGRV
310
IAVSTLHTQH DAHDPKGEA
Length:319
Mass (Da):35,382
Last modified:March 1, 2003 - v1
Checksum:iCBB2D177B7E47A11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF484556 Genomic DNA. Translation: AAN85524.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF484556 Genomic DNA. Translation: AAN85524.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HZN X-ray 2.25 A 1-319 [» ]
4HZO X-ray 1.76 A 2-319 [» ]
4HZP X-ray 1.77 A 2-319 [» ]
ProteinModelPortali Q8GGP1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.10.129.10. 1 hit.
InterProi IPR029069. HotDog_dom.
[Graphical view ]
SUPFAMi SSF54637. SSF54637. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140."
    Cheng Y.-Q., Tang G.-L., Shen B.
    J. Bacteriol. 184:7013-7024(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cheng Y.-Q., Tang G.-L., Shen B.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis."
    Cheng Y.Q., Tang G.L., Shen B.
    Proc. Natl. Acad. Sci. U.S.A. 100:3149-3154(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase."
    Tang G.L., Cheng Y.Q., Shen B.
    Chem. Biol. 11:33-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  5. "Structure of the bifunctional acyltransferase/decarboxylase LnmK from the leinamycin biosynthetic pathway revealing novel activity for a double-hot-dog fold."
    Lohman J.R., Bingman C.A., Phillips G.N., Shen B.
    Biochemistry 52:902-911(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) OF 2-319 IN COMPLEX WITH COENZYMEA.

Entry informationi

Entry nameiQ8GGP1_STRAZ
AccessioniPrimary (citable) accession number: Q8GGP1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3