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Q8GGP1

- Q8GGP1_STRAZ

UniProt

Q8GGP1 - Q8GGP1_STRAZ

Protein
Submitted name:

Conserved hypthetical protein

Gene

LnmK

Organism
Streptomyces atroolivaceus
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei65 – 651CoenzymeA; via amide nitrogen and carbonyl oxygenImported
    Binding sitei140 – 1401Coenzyme A
    Binding sitei140 – 1401CoenzymeAImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Conserved hypthetical proteinImported
    Gene namesi
    Name:LnmKImported
    OrganismiStreptomyces atroolivaceusImported
    Taxonomic identifieri66869 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HZNX-ray2.25A1-319[»]
    4HZOX-ray1.76A2-319[»]
    4HZPX-ray1.77A2-319[»]
    ProteinModelPortaliQ8GGP1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni260 – 2634CoenzymeA bindingImported

    Family and domain databases

    Gene3Di3.10.129.10. 1 hit.
    InterProiIPR029069. HotDog_dom.
    [Graphical view]
    SUPFAMiSSF54637. SSF54637. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8GGP1-1 [UniParc]FASTAAdd to Basket

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    MTITSSLDVR PEIKQAVTVR PGMCGPGSLF VGQLGDWTWE TVSAQCDTDV    50
    FAARDASGNP TYLAFYYFRV RGGRELHPGS LTFGDRLTVT SGCYDQGTES 100
    VLTLHRIDRA GSDDAQRPLD LHEFYERPRD GSLYVENFNR WVTRSAPGSN 150
    EDLVKSSPPG FRNDGLPQLP AAYSPRAVYR EARTAHTFRA LDEPGFRLLP 200
    DTVEVEHPVD IVRDVNGVGL LYFASYFSMV DKAALALWRR LGRSDRAFLR 250
    RVVVDQQMCY LGNADLDSVL TLGARVRVST ETPGEELVDV VISDRDSGRV 300
    IAVSTLHTQH DAHDPKGEA 319
    Length:319
    Mass (Da):35,382
    Last modified:March 1, 2003 - v1
    Checksum:iCBB2D177B7E47A11
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF484556 Genomic DNA. Translation: AAN85524.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF484556 Genomic DNA. Translation: AAN85524.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HZN X-ray 2.25 A 1-319 [» ]
    4HZO X-ray 1.76 A 2-319 [» ]
    4HZP X-ray 1.77 A 2-319 [» ]
    ProteinModelPortali Q8GGP1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.10.129.10. 1 hit.
    InterProi IPR029069. HotDog_dom.
    [Graphical view ]
    SUPFAMi SSF54637. SSF54637. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140."
      Cheng Y.-Q., Tang G.-L., Shen B.
      J. Bacteriol. 184:7013-7024(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Cheng Y.-Q., Tang G.-L., Shen B.
      Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis."
      Cheng Y.Q., Tang G.L., Shen B.
      Proc. Natl. Acad. Sci. U.S.A. 100:3149-3154(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    4. "Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase."
      Tang G.L., Cheng Y.Q., Shen B.
      Chem. Biol. 11:33-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    5. "Structure of the bifunctional acyltransferase/decarboxylase LnmK from the leinamycin biosynthetic pathway revealing novel activity for a double-hot-dog fold."
      Lohman J.R., Bingman C.A., Phillips G.N., Shen B.
      Biochemistry 52:902-911(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) OF 2-319 IN COMPLEX WITH COENZYMEA.

    Entry informationi

    Entry nameiQ8GGP1_STRAZ
    AccessioniPrimary (citable) accession number: Q8GGP1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3