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Q8GGP1 (Q8GGP1_STRAZ) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Ontologies

Keywords
   LigandChloride PDB 4HZO PDB 4HZP
   Technical term3D-structure PDB 4HZN PDB 4HZO PDB 4HZP
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region69 – 713Sulfate 1 binding PDB 4HZN PDB 4HZP
Region174 – 1763Sulfate 4 binding PDB 4HZN
Region179 – 1835Sulfate 3 binding PDB 4HZP
Region244 – 2463Sulfate 6 binding PDB 4HZN
Region260 – 2634Coenzyme A binding PDB 4HZO PDB 4HZP

Sites

Binding site651Coenzyme A; via amide nitrogen and carbonyl oxygen PDB 4HZO PDB 4HZP
Binding site1401Coenzyme A PDB 4HZO
Binding site1401Sulfate 2 PDB 4HZN
Binding site1401Sulfate 3 PDB 4HZP
Binding site1761Sulfate 2 PDB 4HZN
Binding site1831Sulfate 5 PDB 4HZN
Binding site2161Chloride PDB 4HZO PDB 4HZP
Binding site2231Chloride; via amide nitrogen PDB 4HZO PDB 4HZP
Binding site2501Sulfate 6 PDB 4HZN

Sequences

Sequence LengthMass (Da)Tools
Q8GGP1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: CBB2D177B7E47A11

FASTA31935,382
        10         20         30         40         50         60 
MTITSSLDVR PEIKQAVTVR PGMCGPGSLF VGQLGDWTWE TVSAQCDTDV FAARDASGNP 

        70         80         90        100        110        120 
TYLAFYYFRV RGGRELHPGS LTFGDRLTVT SGCYDQGTES VLTLHRIDRA GSDDAQRPLD 

       130        140        150        160        170        180 
LHEFYERPRD GSLYVENFNR WVTRSAPGSN EDLVKSSPPG FRNDGLPQLP AAYSPRAVYR 

       190        200        210        220        230        240 
EARTAHTFRA LDEPGFRLLP DTVEVEHPVD IVRDVNGVGL LYFASYFSMV DKAALALWRR 

       250        260        270        280        290        300 
LGRSDRAFLR RVVVDQQMCY LGNADLDSVL TLGARVRVST ETPGEELVDV VISDRDSGRV 

       310 
IAVSTLHTQH DAHDPKGEA 

« Hide

References

[1]"Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140."
Cheng Y.-Q., Tang G.-L., Shen B.
J. Bacteriol. 184:7013-7024(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]Cheng Y.-Q., Tang G.-L., Shen B.
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]"Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis."
Cheng Y.Q., Tang G.L., Shen B.
Proc. Natl. Acad. Sci. U.S.A. 100:3149-3154(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[4]"Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase."
Tang G.L., Cheng Y.Q., Shen B.
Chem. Biol. 11:33-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[5]"Structure of the bifunctional acyltransferase/decarboxylase LnmK from the leinamycin biosynthetic pathway revealing novel activity for a double-hot-dog fold."
Lohman J.R., Bingman C.A., Phillips G.N., Shen B.
Biochemistry 52:902-911(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) OF 2-319 IN COMPLEX WITH CHLORIDE; COENZYME A AND SULFATE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF484556 Genomic DNA. Translation: AAN85524.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4HZNX-ray2.25A1-319[»]
4HZOX-ray1.76A2-319[»]
4HZPX-ray1.77A2-319[»]
ProteinModelPortalQ8GGP1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.10.129.10. 1 hit.
InterProIPR029069. HotDog_dom.
[Graphical view]
SUPFAMSSF54637. SSF54637. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ8GGP1_STRAZ
AccessionPrimary (citable) accession number: Q8GGP1
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)