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Protein

Arsenite oxidase subunit AioA

Gene

aioA

Organism
Herminiimonas arsenicoxydans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the detoxification of arsenic. Oxidizes As(III)O33- (arsenite) to the somewhat less toxic As(V)O43- (arsenate).

Catalytic activityi

Arsenite + H2O + 2 oxidized azurin = arsenate + 2 reduced azurin + 2 H+.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi22 – 221Iron-sulfur (3Fe-4S)By similarity
Metal bindingi25 – 251Iron-sulfur (3Fe-4S)By similarity
Metal bindingi29 – 291Iron-sulfur (3Fe-4S)By similarity
Sitei100 – 1001Involved in charge transferBy similarity
Binding sitei196 – 1961SubstrateBy similarity
Binding sitei204 – 2041SubstrateBy similarity
Binding sitei419 – 4191SubstrateBy similarity
Binding sitei423 – 4231SubstrateBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

3Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum

Enzyme and pathway databases

BioCyciHARS204773:GJCA-457-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenite oxidase subunit AioA (EC:1.20.9.1)
Alternative name(s):
Arsenite oxidase Mo-pterin subunit
Gene namesi
Name:aioA
Synonyms:aoxB
Ordered Locus Names:HEAR0478
OrganismiHerminiimonas arsenicoxydans
Taxonomic identifieri204773 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas
Proteomesi
  • UP000006697 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 826826Arsenite oxidase subunit AioAPRO_0000063241Add
BLAST

Expressioni

Inductioni

Induced in the presence of arsenite.1 Publication

Interactioni

Subunit structurei

Heterodimer consisting of a large and a small subunit.

Protein-protein interaction databases

STRINGi204773.HEAR0478.

Structurei

3D structure databases

ProteinModelPortaliQ8GGJ6.
SMRiQ8GGJ6. Positions 6-823.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108K28. Bacteria.
COG0243. LUCA.
HOGENOMiHOG000249382.
KOiK08356.
OMAiIVGCGYK.
OrthoDBiPOG091H1UEF.

Family and domain databases

InterProiIPR014066. Arsenite_oxidase_lsu.
IPR009010. Asp_de-COase-like_dom.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
[Graphical view]
PfamiPF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
TIGRFAMsiTIGR02693. arsenite_ox_L. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8GGJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNRDRVAL PPVNAQKTNM TCHFCIVGCG YHVYKWDENK EGGRAANQNA
60 70 80 90 100
LGLDFTKQLP PFATTLTPAM TNVITAKNGK RSNIMIIPDK ECVVNQGLSS
110 120 130 140 150
TRGGKMAGYM YAADGMTADR LKYPRFYAGD QWLDTSWDHA MAIYAGLTKK
160 170 180 190 200
ILDQGNVRDI MFATFDHGGA GGGFENTWGS GKLMFSAIQT PTVRIHNRPA
210 220 230 240 250
YNSECHATRE MGIGELNNSY EDAQVADVIW SIGNNPYETQ TNYFLNHWLP
260 270 280 290 300
NLNGSTEEKK KQWFAGEPVG PGLMIFVDPR RTTSIAIAEQ TAKDRVLHLD
310 320 330 340 350
INPGTDVALF NGLLTYVVQQ GWIAKEFIAQ HTVGFEDAVK TNQMSLADCS
360 370 380 390 400
RITGVSEDKL RQAAEWSYKP KAAGKMPRTM HAYEKGIIWG NDNYNIQSSL
410 420 430 440 450
LDLVIATQNV GRRGTGCVRM GGHQEGYVRP PHPTGEKIYV DQEIIQGKGR
460 470 480 490 500
MMTWWGCNNF QTSNNAQALR EVSLRRSQIV KDAMSKARGA SAAEMVDIIY
510 520 530 540 550
DATSKGGLFV TSINLYPTKL SEAAHLMLPA AHPGEMNLTS MNGERRMRLS
560 570 580 590 600
EKFMDAPGDA LPDCLIAAKA ANTLKAMYEA EGKPEMVKRF SGFDWKTEED
610 620 630 640 650
AFNDGFRSAG QPGAEPIDSQ GGSTGVLATY TLLRAAGTNG VQLPIKRVEN
660 670 680 690 700
GKMIGTAIHY DDNKFDTKDG KAHFKPAPWN GLPKPVEEQK AKHKFWLNNG
710 720 730 740 750
RANEVWQSAY HDQYNDFVKS RYPLAYIELN PGDAQSLGVA AGDVVEVFND
760 770 780 790 800
YGSTFAMAYP VKDMKPSHTF MLFGYVNGIQ GDVTTDWVDR NIIPYYKGTW
810 820
GSVRRIGSIE QYKKTVSTKR RAFDNV
Length:826
Mass (Da):91,627
Last modified:July 24, 2007 - v2
Checksum:iEE690A8B31A7C010
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti318 – 3181V → L in AAN05581 (PubMed:12486049).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF509588 Genomic DNA. Translation: AAN05581.1.
CU207211 Genomic DNA. Translation: CAL60690.1.
RefSeqiWP_011870033.1. NC_009138.1.

Genome annotation databases

EnsemblBacteriaiCAL60690; CAL60690; HEAR0478.
KEGGihar:HEAR0478.
PATRICi22111120. VBIHerArs17568_0451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF509588 Genomic DNA. Translation: AAN05581.1.
CU207211 Genomic DNA. Translation: CAL60690.1.
RefSeqiWP_011870033.1. NC_009138.1.

3D structure databases

ProteinModelPortaliQ8GGJ6.
SMRiQ8GGJ6. Positions 6-823.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi204773.HEAR0478.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL60690; CAL60690; HEAR0478.
KEGGihar:HEAR0478.
PATRICi22111120. VBIHerArs17568_0451.

Phylogenomic databases

eggNOGiENOG4108K28. Bacteria.
COG0243. LUCA.
HOGENOMiHOG000249382.
KOiK08356.
OMAiIVGCGYK.
OrthoDBiPOG091H1UEF.

Enzyme and pathway databases

BioCyciHARS204773:GJCA-457-MONOMER.

Family and domain databases

InterProiIPR014066. Arsenite_oxidase_lsu.
IPR009010. Asp_de-COase-like_dom.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
[Graphical view]
PfamiPF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
TIGRFAMsiTIGR02693. arsenite_ox_L. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAIOA_HERAR
AccessioniPrimary (citable) accession number: Q8GGJ6
Secondary accession number(s): A4G2F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: July 24, 2007
Last modified: September 7, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.