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Protein

Arsenite oxidase subunit AioA

Gene

aioA

Organism
Herminiimonas arsenicoxydans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the detoxification of arsenic. Oxidizes As(III)O33- (arsenite) to the somewhat less toxic As(V)O43- (arsenate).

Catalytic activityi

Arsenite + H2O + 2 oxidized azurin = arsenate + 2 reduced azurin + 2 H+.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi22Iron-sulfur (3Fe-4S)By similarity1
Metal bindingi25Iron-sulfur (3Fe-4S)By similarity1
Metal bindingi29Iron-sulfur (3Fe-4S)By similarity1
Sitei100Involved in charge transferBy similarity1
Binding sitei196SubstrateBy similarity1
Binding sitei204SubstrateBy similarity1
Binding sitei419SubstrateBy similarity1
Binding sitei423SubstrateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Ligand3Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum

Enzyme and pathway databases

BioCyciHARS204773:G1GI6-440-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenite oxidase subunit AioA (EC:1.20.9.1)
Alternative name(s):
Arsenite oxidase Mo-pterin subunit
Gene namesi
Name:aioA
Synonyms:aoxB
Ordered Locus Names:HEAR0478
OrganismiHerminiimonas arsenicoxydans
Taxonomic identifieri204773 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas
Proteomesi
  • UP000006697 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000632411 – 826Arsenite oxidase subunit AioAAdd BLAST826

Proteomic databases

PRIDEiQ8GGJ6

Expressioni

Inductioni

Induced in the presence of arsenite.1 Publication

Interactioni

Subunit structurei

Heterodimer consisting of a large and a small subunit.

Protein-protein interaction databases

STRINGi204773.HEAR0478

Structurei

3D structure databases

ProteinModelPortaliQ8GGJ6
SMRiQ8GGJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108K28 Bacteria
COG0243 LUCA
HOGENOMiHOG000249382
KOiK08356
OMAiIVGCGYK
OrthoDBiPOG091H1UEF

Family and domain databases

InterProiView protein in InterPro
IPR014066 Arsenite_oxidase_lsu
IPR009010 Asp_de-COase-like_dom_sf
IPR006657 MoPterin_dinucl-bd_dom
IPR006656 Mopterin_OxRdtase
PfamiView protein in Pfam
PF00384 Molybdopterin, 1 hit
PF01568 Molydop_binding, 1 hit
SUPFAMiSSF50692 SSF50692, 1 hit
TIGRFAMsiTIGR02693 arsenite_ox_L, 1 hit

Sequencei

Sequence statusi: Complete.

Q8GGJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNRDRVAL PPVNAQKTNM TCHFCIVGCG YHVYKWDENK EGGRAANQNA
60 70 80 90 100
LGLDFTKQLP PFATTLTPAM TNVITAKNGK RSNIMIIPDK ECVVNQGLSS
110 120 130 140 150
TRGGKMAGYM YAADGMTADR LKYPRFYAGD QWLDTSWDHA MAIYAGLTKK
160 170 180 190 200
ILDQGNVRDI MFATFDHGGA GGGFENTWGS GKLMFSAIQT PTVRIHNRPA
210 220 230 240 250
YNSECHATRE MGIGELNNSY EDAQVADVIW SIGNNPYETQ TNYFLNHWLP
260 270 280 290 300
NLNGSTEEKK KQWFAGEPVG PGLMIFVDPR RTTSIAIAEQ TAKDRVLHLD
310 320 330 340 350
INPGTDVALF NGLLTYVVQQ GWIAKEFIAQ HTVGFEDAVK TNQMSLADCS
360 370 380 390 400
RITGVSEDKL RQAAEWSYKP KAAGKMPRTM HAYEKGIIWG NDNYNIQSSL
410 420 430 440 450
LDLVIATQNV GRRGTGCVRM GGHQEGYVRP PHPTGEKIYV DQEIIQGKGR
460 470 480 490 500
MMTWWGCNNF QTSNNAQALR EVSLRRSQIV KDAMSKARGA SAAEMVDIIY
510 520 530 540 550
DATSKGGLFV TSINLYPTKL SEAAHLMLPA AHPGEMNLTS MNGERRMRLS
560 570 580 590 600
EKFMDAPGDA LPDCLIAAKA ANTLKAMYEA EGKPEMVKRF SGFDWKTEED
610 620 630 640 650
AFNDGFRSAG QPGAEPIDSQ GGSTGVLATY TLLRAAGTNG VQLPIKRVEN
660 670 680 690 700
GKMIGTAIHY DDNKFDTKDG KAHFKPAPWN GLPKPVEEQK AKHKFWLNNG
710 720 730 740 750
RANEVWQSAY HDQYNDFVKS RYPLAYIELN PGDAQSLGVA AGDVVEVFND
760 770 780 790 800
YGSTFAMAYP VKDMKPSHTF MLFGYVNGIQ GDVTTDWVDR NIIPYYKGTW
810 820
GSVRRIGSIE QYKKTVSTKR RAFDNV
Length:826
Mass (Da):91,627
Last modified:July 24, 2007 - v2
Checksum:iEE690A8B31A7C010
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti318V → L in AAN05581 (PubMed:12486049).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF509588 Genomic DNA Translation: AAN05581.1
CU207211 Genomic DNA Translation: CAL60690.1
RefSeqiWP_011870033.1, NC_009138.1

Genome annotation databases

EnsemblBacteriaiCAL60690; CAL60690; HEAR0478
KEGGihar:HEAR0478

Similar proteinsi

Entry informationi

Entry nameiAIOA_HERAR
AccessioniPrimary (citable) accession number: Q8GGJ6
Secondary accession number(s): A4G2F3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: July 24, 2007
Last modified: May 23, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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