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Q8GDP4

- HISX_HELMO

UniProt

Q8GDP4 - HISX_HELMO

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Heliobacillus mobilis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei126 – 1261NADUniRule annotation
    Binding sitei188 – 1881NADUniRule annotation
    Binding sitei210 – 2101NADUniRule annotation
    Binding sitei233 – 2331SubstrateUniRule annotation
    Metal bindingi255 – 2551ZincUniRule annotation
    Binding sitei255 – 2551SubstrateUniRule annotation
    Metal bindingi258 – 2581ZincUniRule annotation
    Binding sitei258 – 2581SubstrateUniRule annotation
    Active sitei323 – 3231Proton acceptorUniRule annotation
    Active sitei324 – 3241Proton acceptorUniRule annotation
    Binding sitei324 – 3241SubstrateUniRule annotation
    Metal bindingi357 – 3571ZincUniRule annotation
    Binding sitei357 – 3571SubstrateUniRule annotation
    Binding sitei411 – 4111SubstrateUniRule annotation
    Metal bindingi416 – 4161ZincUniRule annotation
    Binding sitei416 – 4161SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    OrganismiHeliobacillus mobilis
    Taxonomic identifieri28064 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesHeliobacteriaceaeHeliobacillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›426›426Histidinol dehydrogenasePRO_0000135780Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ8GDP4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q8GDP4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRLITYPSI DADNYLQKKT LDDANVSVQV AQVLETIRCR GVEAVFEYTK    50
    RFDGATVNEA NFRVSEAEID EAYSKVDPEV LAALRRARDN IRRYHEKQLR 100
    PSWIEPEADG TMLGQLIRPL ERVGTYVPGG LASYPSSVLM NAVPAKVAGV 150
    PQVVMATPPG KDGSINPYTL VAAREAGVDE IYRMGGAQAV AAMAYGAGLK 200
    AVDKITGPGN IYVTLAKKQV YGTVDIDMLA GPSEILVIAD ETAPPAYVAA 250
    DFLSQVEHDV RAAAVLVTPS EILARAVEGE IQRQMDYLPR REIMEQALKD 300
    NSAVIVVKDL DEACEVANRY APEHLEVLTK EPFALLGKLT QAGAIFLGPY 350
    SPEPVGDYYA GPNHVLPTGG TARFYSPLNV DTFMKKTSVI AYSKARFEQA 400
    ADDILALAKC EGLDAHANAV AVRIEK 426
    Length:426
    Mass (Da):46,201
    Last modified:March 1, 2003 - v1
    Checksum:i8DF8698277EB8A1E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei426 – 4261

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY142932 Genomic DNA. Translation: AAN87536.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY142932 Genomic DNA. Translation: AAN87536.1 .

    3D structure databases

    ProteinModelPortali Q8GDP4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiHISX_HELMO
    AccessioniPrimary (citable) accession number: Q8GDP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3