Reviewed, UniProtKB/Swiss-Prot Q8GB20 (CAIA_PROSL)

Names and origin

Protein names

Recommended name:
    Crotonobetainyl-CoA dehydrogenase
    EC=1.3.99.-
Alternative name(s):
    Crotonobetainyl-CoA reductase

Gene names

Name:

caiA

Organism

Proteus sp. (strain LE138)

Taxonomic identifier

217617 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Proteus

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA By similarity.
Cofactor	FAD By similarity.
Pathway	Amine and polyamine metabolism; carnitine metabolism. HAMAP MF_01052
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the acyl-CoA dehydrogenase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: HAMAP electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 380	380	Crotonobetainyl-CoA dehydrogenase HAMAP MF_01052		PRO_0000201196

Sequences

	Sequence		Length	Mass (Da)
	Q8GB20-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: D49F2D25C394CC3A	FASTA	380	42,837
	10 20 30 40 50 60 MDFRLNDEQE LFVDGVRELM ASENWEAYFA QCDRESKYPE RFVKALADME IDNLLIPEEH 70 80 90 100 110 120 GGLNAGFVTV AAIWMELGRL GAPTYVLYQL PGGFNTVLRE GTQEQIDKIM AFRGTGKQMW 130 140 150 160 170 180 NSAITEPGAG SDVGSLQTTY TRKNGKVYLN GSKCFITSSA YTPYIVVMSR DAASPDKPIF 190 200 210 220 230 240 TEWFVDMSKP GIKVTKLEKL GLRMDSCCEI TFDNVELEEK DMFGREGNGF NRVKEEFDHE 250 260 270 280 290 300 RFLVALTNYG TAMCAFEDAA RYANQRVQFG ETIGRFQLIQ EKFAHMAIKL NSMRNMLYET 310 320 330 340 350 360 AWKSDNGLIT SGDAAMCKYF CANAAFEVVD SAMQVLGGVG IAGEHRIARF WRDLRVDRVS 370 380 GGSDEMQILT LGRAVLKQYR

References

[1]	"Cai locus and corresponding enzymes of Proteus sp." Engemann C., Elssner T., Pfeifer S., Krumbholz C., Maier T., Kleber H.-P. Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ508908 Genomic DNA. Translation: CAD48579.1.
3D structure databases
ModBase	Search...
Family and domain databases
HAMAP	MF_01052. [Tree]
InterPro	IPR006089. Acyl-CoA_DH_CS. IPR006092. Acyl-CoA_DH_N. IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_M. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
Pfam	PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF02771. Acyl-CoA_dh_N. 1 hit. [Graphical view]
PROSITE	PS00072. ACYL_COA_DH_1. 1 hit. PS00073. ACYL_COA_DH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAIA_PROSL

Accession

Primary (citable) accession number: Q8GB20

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	March 1, 2003
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)