Q8GAU4 (KGUA_STRKA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:

gmk

Organism

Streptomyces kasugaensis

Taxonomic identifier

1946 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological_process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 205	205	Guanylate kinase HAMAP-Rule MF_00328		PRO_0000170616
Regions
	Domain	17 – 195	179	Guanylate kinase-like
	Nucleotide binding	24 – 31	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8GAU4 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 95304DC09FFE242D	FASTA	205	22,580
	10 20 30 40 50 60 MAATFRGTTP VPPDARPRLT VLSGPSGVGK STVVAHLRTV HPEVWLSVSA TTRKPRPGEQ 70 80 90 100 110 120 HGVQYFFVDD EEFDKLVANG ELLEWAEFAG NRYGTPRKAV LDRLEAGEPV LLEIDLQGAR 130 140 150 160 170 180 QVRESMADAH LVFLAPPSWE ELVRRLTGRG TEAPEIIERR LAAAKVELAA ETEFDVTLVN 190 200 TSVEDVSREL LALMLRQSGE RDISG

References

[1]

"The rpoZ gene, encoding the RNA polymerase omega subunit, is required for antibiotic production and morphological differentiation in Streptomyces kasugaensis." Kojima I., Kasuga K., Kobayashi M., Fukasawa A., Mizuno S., Arisawa A., Akagawa H. J. Bacteriol. 184:6417-6423(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: A1R6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB081073 Genomic DNA. Translation: BAC23144.1.
3D structure databases
ProteinModelPortal	Q8GAU4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase.
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_STRKA

Accession

Primary (citable) accession number: Q8GAU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2003
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program