Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8G9M2

- GCSP_RHOFA

UniProt

Q8G9M2 - GCSP_RHOFA

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Rhodococcus fascians
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Synonyms:gcvB
    OrganismiRhodococcus fascians
    Taxonomic identifieri1828 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 949›949Glycine dehydrogenase (decarboxylating)PRO_0000166933Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei702 – 7021N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G9M2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q8G9M2-1 [UniParc]FASTAAdd to Basket

    « Hide

    TDRMTSTASA FVDRHVGPDT TELARILDAI GVDSLDELAR KAVPESILDT    50
    VVDGVPDGLA TLPPALSEHD ALAALADLAG CNTVATSMIG LGYYDTLTPP 100
    VLTRGILENP AWYTAYTPYQ PEISQGRLEA LLNFQTMVSD LTGMDVANAS 150
    MLDESTAAAE SMTLMRRANR GSKSPRLVVD SDIFPQTKAV LATRAEPLGI 200
    ELVYADLADG LPEGDFFGVL AQLPGASGRL VDHTATIEAA HERGALVAVG 250
    VDLLAATLVT APGEIGADVC FGTTQRFGVP MGYGGPHAGY LAVRSGHSRQ 300
    LPGRLVGVSV DADGHRAYRL ALQTREQHIR REKATSNICT AQVLLAIVAA 350
    MYASYHGADG LRAIARRVNT RARTVAAGLQ AAGIDVVHAE FFDTVLAAVP 400
    GAAHTVVDAA KQRGINLRPV DDDHVAIACD EATTEAHIVD VLAAFGAEPA 450
    GPGAESVPAD CARTSEYLTH PAFTRYRTET AMLRYLRALS DKDIALDRSM 500
    IPLGSCTMKL NATAEMESIT WPQFARQHPF APSTDVPGLL RVIADLEQWL 550
    VDITGYDAVS LQPNAGSQGE YAGLLAIRRY HQANGDTGRT VCLIPSSAHG 600
    TNAASAVMVG MRVVVVACRP NGDVDVDDLR AKIAEHADTL AAIMITYPST 650
    HGVYEHEISD ICAAVHDAGG QVYVDGANLN ALVGLARPGR FGGDVSHLNL 700
    HKTFCIPHGG GGPGVGPIGV RSHLQPYLPG HPLAPQLGDG PTVAGAPYGS 750
    ASILTITWAY IAMMGAQGLR RATLTAIASA NYIARRLDEY FPVLYTGDNG 800
    MVAHECILDL RGLTKDTGVT VDDVAKRLAD YGFHAPTMSF PVPGTLMVEP 850
    TESENLEEID AFCDAMISIR REIDRVGSGE WTVEDNPLRG APHTAQCLVA 900
    DWNHPYSREL AAYPAGYDRP KVWPAVRRID GAHGDRNLVC SCPPIEAFA 949
    Length:949
    Mass (Da):100,704
    Last modified:March 1, 2003 - v1
    Checksum:i870E324050C6380A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ301559 Genomic DNA. Translation: CAD52982.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ301559 Genomic DNA. Translation: CAD52982.1 .

    3D structure databases

    ProteinModelPortali Q8G9M2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Chromosomal locus that affects pathogenicity of Rhodococcus fascians."
      Vereecke D.M., Cornelis K., Temmerman W., Jaziri M., Van Montagu M., Holsters M., Goethals K.
      J. Bacteriol. 184:1112-1120(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: D188.

    Entry informationi

    Entry nameiGCSP_RHOFA
    AccessioniPrimary (citable) accession number: Q8G9M2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3