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Q8G9M2

- GCSP_RHOFA

UniProt

Q8G9M2 - GCSP_RHOFA

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, gcvB
Organism
Rhodococcus fascians
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Synonyms:gcvB
OrganismiRhodococcus fascians
Taxonomic identifieri1828 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 949›949Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000166933Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei702 – 7021N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8G9M2.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q8G9M2-1 [UniParc]FASTAAdd to Basket

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TDRMTSTASA FVDRHVGPDT TELARILDAI GVDSLDELAR KAVPESILDT    50
VVDGVPDGLA TLPPALSEHD ALAALADLAG CNTVATSMIG LGYYDTLTPP 100
VLTRGILENP AWYTAYTPYQ PEISQGRLEA LLNFQTMVSD LTGMDVANAS 150
MLDESTAAAE SMTLMRRANR GSKSPRLVVD SDIFPQTKAV LATRAEPLGI 200
ELVYADLADG LPEGDFFGVL AQLPGASGRL VDHTATIEAA HERGALVAVG 250
VDLLAATLVT APGEIGADVC FGTTQRFGVP MGYGGPHAGY LAVRSGHSRQ 300
LPGRLVGVSV DADGHRAYRL ALQTREQHIR REKATSNICT AQVLLAIVAA 350
MYASYHGADG LRAIARRVNT RARTVAAGLQ AAGIDVVHAE FFDTVLAAVP 400
GAAHTVVDAA KQRGINLRPV DDDHVAIACD EATTEAHIVD VLAAFGAEPA 450
GPGAESVPAD CARTSEYLTH PAFTRYRTET AMLRYLRALS DKDIALDRSM 500
IPLGSCTMKL NATAEMESIT WPQFARQHPF APSTDVPGLL RVIADLEQWL 550
VDITGYDAVS LQPNAGSQGE YAGLLAIRRY HQANGDTGRT VCLIPSSAHG 600
TNAASAVMVG MRVVVVACRP NGDVDVDDLR AKIAEHADTL AAIMITYPST 650
HGVYEHEISD ICAAVHDAGG QVYVDGANLN ALVGLARPGR FGGDVSHLNL 700
HKTFCIPHGG GGPGVGPIGV RSHLQPYLPG HPLAPQLGDG PTVAGAPYGS 750
ASILTITWAY IAMMGAQGLR RATLTAIASA NYIARRLDEY FPVLYTGDNG 800
MVAHECILDL RGLTKDTGVT VDDVAKRLAD YGFHAPTMSF PVPGTLMVEP 850
TESENLEEID AFCDAMISIR REIDRVGSGE WTVEDNPLRG APHTAQCLVA 900
DWNHPYSREL AAYPAGYDRP KVWPAVRRID GAHGDRNLVC SCPPIEAFA 949
Length:949
Mass (Da):100,704
Last modified:March 1, 2003 - v1
Checksum:i870E324050C6380A
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ301559 Genomic DNA. Translation: CAD52982.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ301559 Genomic DNA. Translation: CAD52982.1 .

3D structure databases

ProteinModelPortali Q8G9M2.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Chromosomal locus that affects pathogenicity of Rhodococcus fascians."
    Vereecke D.M., Cornelis K., Temmerman W., Jaziri M., Van Montagu M., Holsters M., Goethals K.
    J. Bacteriol. 184:1112-1120(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: D188.

Entry informationi

Entry nameiGCSP_RHOFA
AccessioniPrimary (citable) accession number: Q8G9M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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