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Q8G9M2

- GCSP_RHOFA

UniProt

Q8G9M2 - GCSP_RHOFA

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Rhodococcus fascians
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Synonyms:gcvB
OrganismiRhodococcus fascians
Taxonomic identifieri1828 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 949›949Glycine dehydrogenase (decarboxylating)PRO_0000166933Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei702 – 7021N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8G9M2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q8G9M2-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
TDRMTSTASA FVDRHVGPDT TELARILDAI GVDSLDELAR KAVPESILDT
60 70 80 90 100
VVDGVPDGLA TLPPALSEHD ALAALADLAG CNTVATSMIG LGYYDTLTPP
110 120 130 140 150
VLTRGILENP AWYTAYTPYQ PEISQGRLEA LLNFQTMVSD LTGMDVANAS
160 170 180 190 200
MLDESTAAAE SMTLMRRANR GSKSPRLVVD SDIFPQTKAV LATRAEPLGI
210 220 230 240 250
ELVYADLADG LPEGDFFGVL AQLPGASGRL VDHTATIEAA HERGALVAVG
260 270 280 290 300
VDLLAATLVT APGEIGADVC FGTTQRFGVP MGYGGPHAGY LAVRSGHSRQ
310 320 330 340 350
LPGRLVGVSV DADGHRAYRL ALQTREQHIR REKATSNICT AQVLLAIVAA
360 370 380 390 400
MYASYHGADG LRAIARRVNT RARTVAAGLQ AAGIDVVHAE FFDTVLAAVP
410 420 430 440 450
GAAHTVVDAA KQRGINLRPV DDDHVAIACD EATTEAHIVD VLAAFGAEPA
460 470 480 490 500
GPGAESVPAD CARTSEYLTH PAFTRYRTET AMLRYLRALS DKDIALDRSM
510 520 530 540 550
IPLGSCTMKL NATAEMESIT WPQFARQHPF APSTDVPGLL RVIADLEQWL
560 570 580 590 600
VDITGYDAVS LQPNAGSQGE YAGLLAIRRY HQANGDTGRT VCLIPSSAHG
610 620 630 640 650
TNAASAVMVG MRVVVVACRP NGDVDVDDLR AKIAEHADTL AAIMITYPST
660 670 680 690 700
HGVYEHEISD ICAAVHDAGG QVYVDGANLN ALVGLARPGR FGGDVSHLNL
710 720 730 740 750
HKTFCIPHGG GGPGVGPIGV RSHLQPYLPG HPLAPQLGDG PTVAGAPYGS
760 770 780 790 800
ASILTITWAY IAMMGAQGLR RATLTAIASA NYIARRLDEY FPVLYTGDNG
810 820 830 840 850
MVAHECILDL RGLTKDTGVT VDDVAKRLAD YGFHAPTMSF PVPGTLMVEP
860 870 880 890 900
TESENLEEID AFCDAMISIR REIDRVGSGE WTVEDNPLRG APHTAQCLVA
910 920 930 940
DWNHPYSREL AAYPAGYDRP KVWPAVRRID GAHGDRNLVC SCPPIEAFA
Length:949
Mass (Da):100,704
Last modified:March 1, 2003 - v1
Checksum:i870E324050C6380A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ301559 Genomic DNA. Translation: CAD52982.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ301559 Genomic DNA. Translation: CAD52982.1 .

3D structure databases

ProteinModelPortali Q8G9M2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Chromosomal locus that affects pathogenicity of Rhodococcus fascians."
    Vereecke D.M., Cornelis K., Temmerman W., Jaziri M., Van Montagu M., Holsters M., Goethals K.
    J. Bacteriol. 184:1112-1120(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: D188.

Entry informationi

Entry nameiGCSP_RHOFA
AccessioniPrimary (citable) accession number: Q8G9M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3