Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8G9M2 (GCSP_RHOFA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Synonyms:gcvB
OrganismRhodococcus fascians
Taxonomic identifier1828 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus

Protein attributes

Sequence length949 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 949›949Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166933

Amino acid modifications

Modified residue7021N6-(pyridoxal phosphate)lysine By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q8G9M2 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 870E324050C6380A

FASTA949100,704
        10         20         30         40         50         60 
TDRMTSTASA FVDRHVGPDT TELARILDAI GVDSLDELAR KAVPESILDT VVDGVPDGLA 

        70         80         90        100        110        120 
TLPPALSEHD ALAALADLAG CNTVATSMIG LGYYDTLTPP VLTRGILENP AWYTAYTPYQ 

       130        140        150        160        170        180 
PEISQGRLEA LLNFQTMVSD LTGMDVANAS MLDESTAAAE SMTLMRRANR GSKSPRLVVD 

       190        200        210        220        230        240 
SDIFPQTKAV LATRAEPLGI ELVYADLADG LPEGDFFGVL AQLPGASGRL VDHTATIEAA 

       250        260        270        280        290        300 
HERGALVAVG VDLLAATLVT APGEIGADVC FGTTQRFGVP MGYGGPHAGY LAVRSGHSRQ 

       310        320        330        340        350        360 
LPGRLVGVSV DADGHRAYRL ALQTREQHIR REKATSNICT AQVLLAIVAA MYASYHGADG 

       370        380        390        400        410        420 
LRAIARRVNT RARTVAAGLQ AAGIDVVHAE FFDTVLAAVP GAAHTVVDAA KQRGINLRPV 

       430        440        450        460        470        480 
DDDHVAIACD EATTEAHIVD VLAAFGAEPA GPGAESVPAD CARTSEYLTH PAFTRYRTET 

       490        500        510        520        530        540 
AMLRYLRALS DKDIALDRSM IPLGSCTMKL NATAEMESIT WPQFARQHPF APSTDVPGLL 

       550        560        570        580        590        600 
RVIADLEQWL VDITGYDAVS LQPNAGSQGE YAGLLAIRRY HQANGDTGRT VCLIPSSAHG 

       610        620        630        640        650        660 
TNAASAVMVG MRVVVVACRP NGDVDVDDLR AKIAEHADTL AAIMITYPST HGVYEHEISD 

       670        680        690        700        710        720 
ICAAVHDAGG QVYVDGANLN ALVGLARPGR FGGDVSHLNL HKTFCIPHGG GGPGVGPIGV 

       730        740        750        760        770        780 
RSHLQPYLPG HPLAPQLGDG PTVAGAPYGS ASILTITWAY IAMMGAQGLR RATLTAIASA 

       790        800        810        820        830        840 
NYIARRLDEY FPVLYTGDNG MVAHECILDL RGLTKDTGVT VDDVAKRLAD YGFHAPTMSF 

       850        860        870        880        890        900 
PVPGTLMVEP TESENLEEID AFCDAMISIR REIDRVGSGE WTVEDNPLRG APHTAQCLVA 

       910        920        930        940 
DWNHPYSREL AAYPAGYDRP KVWPAVRRID GAHGDRNLVC SCPPIEAFA 

« Hide

References

[1]"Chromosomal locus that affects pathogenicity of Rhodococcus fascians."
Vereecke D.M., Cornelis K., Temmerman W., Jaziri M., Van Montagu M., Holsters M., Goethals K.
J. Bacteriol. 184:1112-1120(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: D188.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ301559 Genomic DNA. Translation: CAD52982.1.

3D structure databases

ProteinModelPortalQ8G9M2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_RHOFA
AccessionPrimary (citable) accession number: Q8G9M2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families