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Q8G9C6

- TRMB_AROAE

UniProt

Q8G9C6 - TRMB_AROAE

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, AZOSEA12950, c1A43
Organism
Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911S-adenosyl-L-methionine By similarity
Binding sitei116 – 1161S-adenosyl-L-methionine By similarity
Binding sitei143 – 1431S-adenosyl-L-methionine By similarity
Active sitei166 – 1661 By similarity
Binding sitei166 – 1661S-adenosyl-L-methionine By similarity
Binding sitei170 – 1701Substrate By similarity
Binding sitei202 – 2021Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciAARO76114:GJTA-1314-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:AZOSEA12950
ORF Names:c1A43
OrganismiAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Taxonomic identifieri76114 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum
ProteomesiUP000006552: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000171287Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi76114.c1A43.

Structurei

3D structure databases

ProteinModelPortaliQ8G9C6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni237 – 2404Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiRERANAK.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G9C6-1 [UniParc]FASTAAdd to Basket

« Hide

MTFPSHNPPE TGHPSAAPDE ALPAAEAPVP GDPEARFSSR SIRSFVLRQG    50
RMSVAQQRHL DETLPKVGIP YRVAPLDLDA AFGRAAPKIV EIGFGMGETT 100
AKIAAALPDK DFLTIEVHGP GVGSLCKLIA EGVLDNVRIV QHDAVEVLRD 150
MIPERALAGV HVFFPDPWHK KRHHKRRIIQ PDFVALIASR LAPGAYLHCA 200
TDWEEYAQWM LEVLAAEPAL ENTADGYAPR PAYRPLTKFE NRGLKLGHGV 250
WDLVFRRRG 259
Length:259
Mass (Da):28,575
Last modified:March 1, 2003 - v1
Checksum:i0659D4B4511FD1C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR555306 Genomic DNA. Translation: CAI07420.1.
RefSeqiYP_158321.1. NC_006513.1.

Genome annotation databases

EnsemblBacteriaiCAI07420; CAI07420; c1A43.
GeneIDi3180480.
KEGGieba:c1A43.
PATRICi20968707. VBIAroAro98752_1314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR555306 Genomic DNA. Translation: CAI07420.1 .
RefSeqi YP_158321.1. NC_006513.1.

3D structure databases

ProteinModelPortali Q8G9C6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 76114.c1A43.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI07420 ; CAI07420 ; c1A43 .
GeneIDi 3180480.
KEGGi eba:c1A43.
PATRICi 20968707. VBIAroAro98752_1314.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi RERANAK.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci AARO76114:GJTA-1314-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genes involved in the anaerobic degradation of ethylbenzene in a denitrifying bacterium, strain EbN1."
    Rabus R., Kube M., Beck A., Widdel F., Reinhardt R.
    Arch. Microbiol. 178:506-516(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
    Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
    Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EbN1.

Entry informationi

Entry nameiTRMB_AROAE
AccessioniPrimary (citable) accession number: Q8G9C6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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