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Q8G998 (OTCC_LACHI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ornithine carbamoyltransferase, catabolic
Short name=OTCase
EC=2.1.3.3
Gene names
Name:arcB
OrganismLactobacillus hilgardii
Taxonomic identifier1588 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109

Pathway

Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109

Subcellular location

Cytoplasm Probable HAMAP MF_01109.

Sequence similarities

Belongs to the ATCase/OTCase family.

Ontologies

Keywords
   Biological processArginine metabolism
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical term3D-structure
Gene Ontology (GO)
   Biological processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentornithine carbamoyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Ornithine carbamoyltransferase, catabolic HAMAP MF_01109
PRO_0000112932

Regions

Region62 – 665Carbamoyl phosphate binding By similarity
Region277 – 2804Ornithine binding By similarity

Sites

Binding site1131Carbamoyl phosphate By similarity
Binding site1401Carbamoyl phosphate By similarity
Site371Important for structural integrity By similarity
Site1531Important for structural integrity By similarity

Secondary structure

1 .................................................... 343
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8G998 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: FF7158C4581F684B

FASTA34338,280
        10         20         30         40         50         60 
MTKDFRQNVF QGRSVLAEKD FSAAELEYLI DFGLHLKALK KAGIPHHYLE GKNIALLFEK 

        70         80         90        100        110        120 
SSTRTRSAFT TASIDLGAHP EYLGQNDIQL GKKESTSDTA KVLGSMFDGI EFRGFKQSDA 

       130        140        150        160        170        180 
EILARDSGVP VWNGLTDEWH PTQMLADFMT VKENFGKLQG LTLTFMGDGR NNVANSLLVT 

       190        200        210        220        230        240 
GAILGVNIHI VAPKALFPTE ETQNIAKGFA EKSGAKLVIT DDLDEGLKGS NVVYTDVWVS 

       250        260        270        280        290        300 
MGESNWEERV KELTPYQVNM EAMKKTGTPD DQLIFMHCLP AFHNTDTQYG KEIKEKYGIT 

       310        320        330        340 
EMEVTDEVFT SKYARQFEEA ENRMHSIKAM MAATLGNLFI PRV

« Hide

References

[1]"The arginine deiminase pathway in the wine lactic acid bacterium Lactobacillus hilgardii X1B: structural and functional study of the arcABC genes."
Arena M.E., Manca de Nadra M.C., Munoz R.
Gene 301:61-66(2002) [PubMed: 12490324] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: X(1)B.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ421514 Genomic DNA. Translation: CAD13392.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2W37X-ray2.10A/B/C1-343[»]
ProteinModelPortalQ8G998.
SMRQ8G998. Positions 10-338.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

HAMAPMF_01109. OTCase.
[Tree]
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMSSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMsTIGR00658. Orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOTCC_LACHI
AccessionPrimary (citable) accession number: Q8G998
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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