ID   Q8G982_PLAAG            Unreviewed;      2144 AA.
AC   Q8G982;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   08-NOV-2023, entry version 96.
DE   SubName: Full=Peptide synthetase {ECO:0000313|EMBL:CAD29798.1};
GN   Name=mcyB {ECO:0000313|EMBL:CAD29798.1};
OS   Planktothrix agardhii (Oscillatoria agardhii).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC   Oscillatoriales; Microcoleaceae; Planktothrix.
OX   NCBI_TaxID=1160 {ECO:0000313|EMBL:CAD29798.1};
RN   [1] {ECO:0000313|EMBL:CAD29798.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CYA 126/8 {ECO:0000313|EMBL:CAD29798.1};
RX   PubMed=12511503; DOI=10.1128/JB.185.2.564-572.2003;
RA   Christiansen G., Fastner J., Erhard M., Borner T., Dittmann E.;
RT   "Microcystin biosynthesis in planktothrix: genes, evolution, and
RT   manipulation.";
RL   J. Bacteriol. 185:564-572(2003).
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; AJ441056; CAD29798.1; -; Genomic_DNA.
DR   RefSeq; WP_042154171.1; NZ_LR882934.1.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   CDD; cd05930; A_NRPS; 2.
DR   CDD; cd19543; DCL_NRPS; 1.
DR   CDD; cd19531; LCL_NRPS-like; 1.
DR   Gene3D; 3.30.300.30; -; 2.
DR   Gene3D; 3.40.50.980; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 2.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   Pfam; PF00668; Condensation; 2.
DR   Pfam; PF00550; PP-binding; 2.
DR   SMART; SM00823; PKS_PP; 2.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR   PROSITE; PS00455; AMP_BINDING; 2.
DR   PROSITE; PS50075; CARRIER; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          982..1057
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2067..2142
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   2144 AA;  244143 MW;  CD532E76C4F07AD5 CRC64;
     MVAEQSKASH KNVAAIYPLS PMQEGMLFHS LYAPDSGTYC SQTLITLNGE LNLGAFKQAW
     EKVVERHAVL RTLFLWEKRQ KTLQIVRKQV DLPWNYSDWQ PLSPREQQQQ LDALLKDERQ
     RGFALNQAPL MRCHLIQLSQ QSYHFLWNRH HILLDGWSGA IIYGEVLQIY QALCQEQNPY
     LSPARPYEDY IVWLQQQDQS LAENFWRRSL KNFTTPTNLG ITRSILVEPQ SKPVYQSADL
     SLSPGLTEKL QTLAQQQNLT LSTLIQAAWA ILLSRYSGES EVLFGITVSG RPASLSGIEK
     MVGLFINTLP LRVTVTESET ILPWLEELQQ KQAEIQDYAY SSLAEIQRLS DVLPGLPLFE
     SLVIFENYPR EERLTDSPQQ LSVSGVIDFE ETNYPLTVAV IPKQALQFQF SYDVSHFTHE
     SIIRLTGHLE TLLTAIAQNP QQSLGQLPLL TAAERHQLLV EWNDTAVDYP QHQCLHHLVE
     EQVLKTPEAI AVIFEGQELT YQALNERANQ LAHYLQEKGV KPEVLVGIYF ERSLEAIIGI
     LAILKAGGAY VPLDPTYPRD RLDYMLTDSA VSILLTQQSL VTNLREDLDT LKIESFCLDS
     DWLILENYSR ENPSSSVQSE NLAYLIYTSG STGKPKGVMN LHQGICNNIL RTKDSYPTTN
     RDRLLQISSL AFDASVLDIF WSLSSGMALI IPKPEGTKDL AYLIQLMIEK KVSQVFFVPS
     LLRLLLQQPN LENCRYLKRV FCGGEALSSE LMQQFFQHFN CELHNLYGPT ETSVDATCWQ
     CPPRTDDPAI AIGRPIANTQ IYILDRHLQP VPVGIVGELH IGGIPLARGY LNQLELTAEK
     FIPNPFGQGK LYKTGDLVRY LADGNIEYLG RIDNQVKLRG LRIELGEIQT ILDSHPQINQ
     SVVIIQTDSE DNQRLVAYVD SQNQALTPKE LRQFLQPKLP AYMIPSAFVI LPEFPLNANG
     KVDLKKLPQP NETALVESVY VAPRNPTETI LVNIWQEVLS LAKIGINDNF FELGGHSLKA
     ITLVSKIQEK MGIAFAIKQV FSHPTIAEQA GLLTETKNEE NLAILPIPHI PDQVKVATSH
     AQKRFFVLQQ MDLNNVAYHI TSILKLTGEF APDKFKQAMQ LLIDRHESLR TAFVLTDGEP
     QQKVLLHRPF SLVFEDWTEE FNAESRILEI LQEQRKPFDL EKDPLLRSSL YQLSPQSYIL
     FLEIHHIICD GWSMNLLAKE CLGYYQALRQ ELEPTVEPLP IQYRDYAAWQ NNQLKQKDQN
     KNLDYWRQKL DNGQIPRVHL PTDFLRSPLK SYNGSHLSWI LPTEINLQLR KVCQDSKSTL
     FMALVAAVKV LLYRYSGQQD ISIGTEIATR NHPQLQELIG LFLNTLILRD RLDPDQSYQD
     CLSKIRQTVS EALAHSDYPF DRLLEDLNIS REINRTPLFD VLVLLQNFDQ TPTIETLNIQ
     SLDSLTPTSK FDLSFVFSEN QENIRLDLIY NTDLFQKERM EKCLLHFDKL LTAMLANPEQ
     PIGKISLLSD SETALIEDFI RPIPRLEIRT VLDDFADQVR IQSHLPALVY TEDGLTKQLS
     YQELDQLTDI WANNLNNLGI EKESICGVSL EGDYRQVIAM LAVFKARGIY LPLRLDEPEE
     RWQRMIVKTS PAIILIAAEN LEMIKPRLLV LAKPPNLLVV NHQEIQQYYE WNGTNYQEFS
     IVENNNRKDL LMPDADDANY IIFTSGSTGE PKAILGSHGS LRHFINWEKI EFGINHNWRC
     LQIAQINFDP YLRETLVTLC SGGTLYIPDS IDREDLERLL LRLGEWQINL LHTVPSVMRL
     FLNIGRNLPN ANQLLKNLQV LVLGGEPLFV KELCEWHEVF GNQTEFVNIY GASETTFIKH
     FHRIPKPNNI SYARVPGGKT LPDAAFAVID ENRPCAIGEV GEIFVKSPYL TKGYYQDEIL
     TNSVFVPNPL NNGNDLVYRT GDLGRLLPDL TLEVIGRRSD NQIKLNGVRI ELGEIEDAVA
     AIDGVQKALV IADKKEELVT VIAYYQGNNT VNREQISQKL KQVLPTYMQP TFLIQLESFP
     LLPNGKIHRL ALPKPEGNIT QSISQPTGFN QQEALLALVW GELLEIEVSD NNQSFFELGG
     NSLKAMRLVS QIRNQFGVSL RLREIFTHNI LKEQAILIQS RQTK
//