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Protein

Malate dehydrogenase

Gene

mdh

Organism
Francisella tularensis subsp. tularensis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Binding sitei96NADUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Active sitei176Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADUniRule annotation6
Nucleotide bindingi119 – 121NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processTricarboxylic acid cycleUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotationImported
OrganismiFrancisella tularensis subsp. tularensisImported
Taxonomic identifieri119856 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P7MX-ray2.20A/B/C/D1-319[»]
SMRiQ8G942.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 143Ldh_1_NInterPro annotationAdd BLAST139
Domaini147 – 312Ldh_1_CInterPro annotationAdd BLAST166

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213794.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8G942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKKITLVG AGNIGGTLAH LALIKQLGDV VLFDIAQGMP NGKALDLLQT
60 70 80 90 100
CPIEGVDFKV RGTNDYKDLE NSDVVIVTAG VPRKPGMSRD DLLGINIKVM
110 120 130 140 150
QTVGEGIKHN CPNAFVICIT NPLDIMVNML QKFSGVPDNK IVGMAGVLDS
160 170 180 190 200
ARFRTFLADE LNVSVQQVQA YVMGGHGDTM VPLTKMSNVA GVSLEQLVKE
210 220 230 240 250
GKLKQERLDA IVSRTRSGGG EIVALLKTGS AYYAPAAAGI QMAESFLKDK
260 270 280 290 300
KMILPCAAKV KAGMYGLDED LFVGVPTEIS ANGVRPIEVE ISDKEREQLQ
310
VSINAIKDLN KAAAEILAK
Length:319
Mass (Da):34,091
Last modified:March 1, 2003 - v1
Checksum:i13749C47CF1F704D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513300 Genomic DNA. Translation: AAN37788.1.
AF513301 Genomic DNA. Translation: AAN37789.1.
AF513302 Genomic DNA. Translation: AAN37790.1.
AF513303 Genomic DNA. Translation: AAN37791.1.
AF513304 Genomic DNA. Translation: AAN37792.1.
AF513305 Genomic DNA. Translation: AAN37793.1.
AF513306 Genomic DNA. Translation: AAN37794.1.
AF513307 Genomic DNA. Translation: AAN37795.1.
AF513308 Genomic DNA. Translation: AAN37796.1.
AF513309 Genomic DNA. Translation: AAN37797.1.
AF513310 Genomic DNA. Translation: AAN37798.1.
AF513311 Genomic DNA. Translation: AAN37799.1.
AF513312 Genomic DNA. Translation: AAN37800.1.
AF513313 Genomic DNA. Translation: AAN37801.1.
AF513314 Genomic DNA. Translation: AAN37802.1.
RefSeqiWP_003026154.1. NZ_CP017155.1.

Genome annotation databases

PATRICifig|264.20.peg.1988.

Similar proteinsi

Entry informationi

Entry nameiQ8G942_FRATL
AccessioniPrimary (citable) accession number: Q8G942
Secondary accession number(s): A0A0K1NS88
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources