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Q8G864

- SYH_BIFLO

UniProt

Q8G864 - SYH_BIFLO

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Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. histidine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLON206672:GI1E-17-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligase (EC:6.1.1.21)
Alternative name(s):
Histidyl-tRNA synthetase
Short name:
HisRS
Gene namesi
Name:hisS
Ordered Locus Names:BL0017
OrganismiBifidobacterium longum (strain NCC 2705)
Taxonomic identifieri206672 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000000439: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Histidine--tRNA ligasePRO_0000136114Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi206672.BL0017.

Structurei

3D structure databases

ProteinModelPortaliQ8G864.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0124.
HOGENOMiHOG000018071.
KOiK01892.
OMAiGKQIKFA.
OrthoDBiEOG6BPDH4.
PhylomeDBiQ8G864.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G864-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKGASISGF PEWLPSERVV EQRVIDTLRK VFELNGFIGI ETRAVETGAS
60 70 80 90 100
LLKKGETSKE IYLLSRLQEV GHESDTPIEE RLGLHFDLTV PLSRYVVEHS
110 120 130 140 150
GALAFPFKRW QIQKVWRGER PQEGRFREFV QADIDVIGAG DLPDHYEVEL
160 170 180 190 200
PLVMVSALEE LRAYGLPKAT VHANNRKLSE GFYRGLGLTD VEGVLREIDK
210 220 230 240 250
LDKIGADEVA RLLTETCGAT EAQARACLEL AELTASDGAE LAAKFDALCE
260 270 280 290 300
AHGIVKDSEA YTLARQGLDT LAMIVDEAAA IRPGSVIADL KIARGLDYYT
310 320 330 340 350
GSVYETFLDG AASLGSICSG GRYDNLASQG NRKYPGVGLS IGLSRLVSYM
360 370 380 390 400
LHTAGAHANR VSPAAVLVAV WNEEDRPAAN RIANQLRARG IATDVAPTAA
410 420 430 440 450
KLGKQIKYAD KLGIPYVWFP ATAAEGAEGA EPAGDEVKNI VTGEQVAADC
460
TSWEPDTVVA QQTVEI
Length:466
Mass (Da):50,394
Last modified:March 1, 2003 - v1
Checksum:i72729E0E6A7C06C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014295 Genomic DNA. Translation: AAN23884.1.
RefSeqiNP_695248.1. NC_004307.2.

Genome annotation databases

EnsemblBacteriaiAAN23884; AAN23884; BL0017.
GeneIDi1023039.
KEGGiblo:BL0017.
PATRICi21117063. VBIBifLon107831_0018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014295 Genomic DNA. Translation: AAN23884.1 .
RefSeqi NP_695248.1. NC_004307.2.

3D structure databases

ProteinModelPortali Q8G864.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 206672.BL0017.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN23884 ; AAN23884 ; BL0017 .
GeneIDi 1023039.
KEGGi blo:BL0017.
PATRICi 21117063. VBIBifLon107831_0018.

Phylogenomic databases

eggNOGi COG0124.
HOGENOMi HOG000018071.
KOi K01892.
OMAi GKQIKFA.
OrthoDBi EOG6BPDH4.
PhylomeDBi Q8G864.

Enzyme and pathway databases

BioCyci BLON206672:GI1E-17-MONOMER.

Family and domain databases

Gene3Di 3.40.50.800. 1 hit.
HAMAPi MF_00127. His_tRNA_synth.
InterProi IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view ]
PANTHERi PTHR11476. PTHR11476. 1 hit.
Pfami PF03129. HGTP_anticodon. 1 hit.
[Graphical view ]
PIRSFi PIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMi SSF52954. SSF52954. 1 hit.
TIGRFAMsi TIGR00442. hisS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
    Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
    Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCC 2705.

Entry informationi

Entry nameiSYH_BIFLO
AccessioniPrimary (citable) accession number: Q8G864
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3