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Q8G864

- SYH_BIFLO

UniProt

Q8G864 - SYH_BIFLO

Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. histidine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBLON206672:GI1E-17-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidine--tRNA ligase (EC:6.1.1.21)
    Alternative name(s):
    Histidyl-tRNA synthetase
    Short name:
    HisRS
    Gene namesi
    Name:hisS
    Ordered Locus Names:BL0017
    OrganismiBifidobacterium longum (strain NCC 2705)
    Taxonomic identifieri206672 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000000439: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 466466Histidine--tRNA ligasePRO_0000136114Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi206672.BL0017.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G864.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0124.
    HOGENOMiHOG000018071.
    KOiK01892.
    OMAiGKQIKFA.
    OrthoDBiEOG6BPDH4.
    PhylomeDBiQ8G864.

    Family and domain databases

    Gene3Di3.40.50.800. 1 hit.
    HAMAPiMF_00127. His_tRNA_synth.
    InterProiIPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR015807. His-tRNA-ligase.
    IPR004516. HisRS/HisZ.
    [Graphical view]
    PANTHERiPTHR11476. PTHR11476. 1 hit.
    PfamiPF03129. HGTP_anticodon. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
    SUPFAMiSSF52954. SSF52954. 1 hit.
    TIGRFAMsiTIGR00442. hisS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8G864-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKGASISGF PEWLPSERVV EQRVIDTLRK VFELNGFIGI ETRAVETGAS    50
    LLKKGETSKE IYLLSRLQEV GHESDTPIEE RLGLHFDLTV PLSRYVVEHS 100
    GALAFPFKRW QIQKVWRGER PQEGRFREFV QADIDVIGAG DLPDHYEVEL 150
    PLVMVSALEE LRAYGLPKAT VHANNRKLSE GFYRGLGLTD VEGVLREIDK 200
    LDKIGADEVA RLLTETCGAT EAQARACLEL AELTASDGAE LAAKFDALCE 250
    AHGIVKDSEA YTLARQGLDT LAMIVDEAAA IRPGSVIADL KIARGLDYYT 300
    GSVYETFLDG AASLGSICSG GRYDNLASQG NRKYPGVGLS IGLSRLVSYM 350
    LHTAGAHANR VSPAAVLVAV WNEEDRPAAN RIANQLRARG IATDVAPTAA 400
    KLGKQIKYAD KLGIPYVWFP ATAAEGAEGA EPAGDEVKNI VTGEQVAADC 450
    TSWEPDTVVA QQTVEI 466
    Length:466
    Mass (Da):50,394
    Last modified:March 1, 2003 - v1
    Checksum:i72729E0E6A7C06C9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014295 Genomic DNA. Translation: AAN23884.1.
    RefSeqiNP_695248.1. NC_004307.2.

    Genome annotation databases

    EnsemblBacteriaiAAN23884; AAN23884; BL0017.
    GeneIDi1023039.
    KEGGiblo:BL0017.
    PATRICi21117063. VBIBifLon107831_0018.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014295 Genomic DNA. Translation: AAN23884.1 .
    RefSeqi NP_695248.1. NC_004307.2.

    3D structure databases

    ProteinModelPortali Q8G864.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 206672.BL0017.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN23884 ; AAN23884 ; BL0017 .
    GeneIDi 1023039.
    KEGGi blo:BL0017.
    PATRICi 21117063. VBIBifLon107831_0018.

    Phylogenomic databases

    eggNOGi COG0124.
    HOGENOMi HOG000018071.
    KOi K01892.
    OMAi GKQIKFA.
    OrthoDBi EOG6BPDH4.
    PhylomeDBi Q8G864.

    Enzyme and pathway databases

    BioCyci BLON206672:GI1E-17-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.800. 1 hit.
    HAMAPi MF_00127. His_tRNA_synth.
    InterProi IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR015807. His-tRNA-ligase.
    IPR004516. HisRS/HisZ.
    [Graphical view ]
    PANTHERi PTHR11476. PTHR11476. 1 hit.
    Pfami PF03129. HGTP_anticodon. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001549. His-tRNA_synth. 1 hit.
    SUPFAMi SSF52954. SSF52954. 1 hit.
    TIGRFAMsi TIGR00442. hisS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
      Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
      Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCC 2705.

    Entry informationi

    Entry nameiSYH_BIFLO
    AccessioniPrimary (citable) accession number: Q8G864
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3