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Q8G7X0 (THIM_BIFLO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:BL0115
OrganismBifidobacterium longum (strain NCC 2705) [Reference proteome] [HAMAP]
Taxonomic identifier206672 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383823

Sites

Binding site701Substrate; via amide nitrogen By similarity
Binding site1451ATP By similarity
Binding site2171ATP By similarity
Binding site2441Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8G7X0 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: CF6B4FA073435AB8

FASTA31432,498
        10         20         30         40         50         60 
MSNSASSFTG VSSGYTAGTP VPADSPIRDN IADAVRRVRE TTPLAQSFTN FVTINLVANA 

        70         80         90        100        110        120 
QLAAGGTAAM SFLPDDVIET AKIAGANYIN VGTLLPFYKD ALPEIAQRLN YLDKPWVLDP 

       130        140        150        160        170        180 
VAAGIGRTRT AILQAFKAAP PTMIRANASE VIALANMWGL NTETVGDASE HRPAGVESVD 

       190        200        210        220        230        240 
DVESATGAAV ALAQYLTEQH AKHSSHDAST RCAVAVSGIA DLVTDGETVY RLPGGSAMMT 

       250        260        270        280        290        300 
KIIGAGCSLG GVAATYLAVS DPLTAALSAS LLYNRAGEVA DTTSHGPGSF QVAFLDALWN 

       310 
VTAEQVAESE ILVQ 

« Hide

References

[1]"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCC 2705.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014295 Genomic DNA. Translation: AAN23980.1.
RefSeqNP_695344.1. NC_004307.2.

3D structure databases

ProteinModelPortalQ8G7X0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING206672.BL0115.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN23980; AAN23980; BL0115.
GeneID1023241.
KEGGblo:BL0115.
PATRIC21117275. VBIBifLon107831_0123.

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMASPVMAHA.
OrthoDBEOG628F8M.
ProtClustDBCLSK572499.

Enzyme and pathway databases

BioCycBLON206672:GI1E-114-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
ProtoNetSearch...

Entry information

Entry nameTHIM_BIFLO
AccessionPrimary (citable) accession number: Q8G7X0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways