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Q8G7I6 (G6PI_BIFLO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Synonyms:gpi
Ordered Locus Names:BL0279
OrganismBifidobacterium longum (strain NCC 2705) [Reference proteome] [HAMAP]
Taxonomic identifier206672 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium

Protein attributes

Sequence length566 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 566566Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180600

Sites

Active site3741Proton donor By similarity
Active site4051 By similarity
Active site5291 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8G7I6 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: A68089F8BAD007B1

FASTA56662,998
        10         20         30         40         50         60 
MAINPPVDAT QTPEWAALQK HYDELQVEGV SLKKWFAEDA ERVEKLSFDA GDLHFDLSKN 

        70         80         90        100        110        120 
LIKPETLQLF ANLAKAVKLD ERTKAMYTGV HINNTEDRAV LHTALRRPVE DEGKYIVDGQ 

       130        140        150        160        170        180 
DTVKDVRETL DKIYAFADDV RSGKWTGVTG RKIETVVNIG IGGSDLGPVM VYEALKPYAD 

       190        200        210        220        230        240 
AGISARYISN IDPNDLAEKT KGLDPETTLF IIVSKTFTTL ETLTNAREAR TWLLEELTAN 

       250        260        270        280        290        300 
GAIAEGDEAQ KAEAIKKHFV AVSTNLEKVE EFGIDPNNAF GFWNWVGGRY SVDSAVGTSL 

       310        320        330        340        350        360 
AVVFGPARFE EFLHGFHEID EYFANTPFEK NVVVLLGMLN VWYRNFFKVA SHAVLPYDQY 

       370        380        390        400        410        420 
LHRFPAYLQQ LTMESNGKSV RWDGTPVTSE TGEIFWGEPG TNGQHAFYQL IHQGTQLIPA 

       430        440        450        460        470        480 
DFIAFVNTPN PTKDGDQDVH ELFLGNYFAQ TKALAFGKTA DEVRAEGTPE EIVPARVFSG 

       490        500        510        520        530        540 
NRPTTSIFGV ALTPFALGEL IALYEHITFV EGTVWGLDSY DQWGVELGKQ LAKQITPAIS 

       550        560 
QDDDALAAQD ASTQSLIKFY RANREF 

« Hide

References

[1]"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCC 2705.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014295 Genomic DNA. Translation: AAN24120.1.
RefSeqNP_695484.1. NC_004307.2.

3D structure databases

ProteinModelPortalQ8G7I6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING206672.BL0279.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN24120; AAN24120; BL0279.
GeneID1022330.
KEGGblo:BL0279.
PATRIC21119107. VBIBifLon107831_1016.

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000261371.
KOK01810.
OMALKMHFVS.
OrthoDBEOG64R61J.
ProtClustDBPRK00179.

Enzyme and pathway databases

BioCycBLON206672:GI1E-955-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_BIFLO
AccessionPrimary (citable) accession number: Q8G7I6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways