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Q8G7H1 (RNC_BIFLO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease 3

EC=3.1.26.3
Alternative name(s):
Ribonuclease III
Short name=RNase III
Gene names
Name:rnc
Ordered Locus Names:BL0295
OrganismBifidobacterium longum (strain NCC 2705) [Reference proteome] [HAMAP]
Taxonomic identifier206672 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity. HAMAP-Rule MF_00104

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104

Cofactor

Mg2+ By similarity. HAMAP-Rule MF_00104

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00104

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00104.

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 1 RNase III domain.

Sequence caution

The sequence AAN24135.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 242242Ribonuclease 3 HAMAP-Rule MF_00104
PRO_0000228502

Regions

Domain12 – 139128RNase III
Domain165 – 23672DRBM

Sites

Active site551 Potential
Active site1281 By similarity
Metal binding511Magnesium By similarity
Metal binding1251Magnesium By similarity
Metal binding1281Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8G7H1 [UniParc].

Last modified March 21, 2006. Version 2.
Checksum: AA294ECE97373D1C

FASTA24226,080
        10         20         30         40         50         60 
MSNETPQQPT PANELLEALG TTLSPDLLVQ ALTHRSFSHE HPGVANYERL EFLGDAVLEL 

        70         80         90        100        110        120 
VSTETLFTIH PDMTEGQLAK MRAKAVSEDA LSAIAKTKLK VGPYILLGHG EAEQGGAEKN 

       130        140        150        160        170        180 
SILCDIVESL IGATFLEHGI DEARKVIHRL IDDTLAEVAT EGPALDWKTS LTVKAHGLGK 

       190        200        210        220        230        240 
EEPVYHMEVS GPEYAQIFTA RVSLGENGDI IGIGKGSSKR KAQLAAAEAG WKSLDSFKTR 


TK 

« Hide

References

[1]"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCC 2705.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014295 Genomic DNA. Translation: AAN24135.1. Different initiation.
RefSeqNP_695499.1. NC_004307.2.

3D structure databases

ProteinModelPortalQ8G7H1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING206672.BL0295.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN24135; AAN24135; BL0295.
GeneID1022381.
KEGGblo:BL0295.
PATRIC21119145. VBIBifLon107831_1032.

Phylogenomic databases

eggNOGCOG0571.
HOGENOMHOG000246808.
KOK03685.
OMAFANENGH.
OrthoDBEOG6T1WVS.

Enzyme and pathway databases

BioCycBLON206672:GI1E-973-MONOMER.

Family and domain databases

Gene3D1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPMF_00104. RNase_III.
InterProIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMSSF69065. SSF69065. 1 hit.
TIGRFAMsTIGR02191. RNaseIII. 1 hit.
PROSITEPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_BIFLO
AccessionPrimary (citable) accession number: Q8G7H1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: May 14, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families