Reviewed, UniProtKB/Swiss-Prot Q8G7H1 (RNC_BIFLO)

Names and origin

Protein names

Recommended name:
    Ribonuclease 3
    EC=3.1.26.3
Alternative name(s):
    Ribonuclease III
      Short name=RNase III

Gene names

Name:	rnc
Ordered Locus Names:	BL0295

Organism

Bifidobacterium longum [Complete proteome] [HAMAP]

Taxonomic identifier

216816 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs By similarity.
Catalytic activity	Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP MF_00104
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Contains 1 DRBM (double-stranded RNA-binding) domain. Contains 1 RNase III domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	RNA-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mRNA processing Inferred from electronic annotation. Source: HAMAP rRNA catabolic process Inferred from electronic annotation. Source: InterPro rRNA processing Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	double-stranded RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease III activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	Ribonuclease 3 HAMAP MF_00104		PRO_0000228502
Regions
	Domain	12 – 139	128	RNase III
	Domain	165 – 236	72	DRBM

Sequences

	Sequence		Length	Mass (Da)
	Q8G7H1-1 [UniParc]. Last modified March 21, 2006. Version 2. Checksum: AA294ECE97373D1C	FASTA	242	26,080
	10 20 30 40 50 60 MSNETPQQPT PANELLEALG TTLSPDLLVQ ALTHRSFSHE HPGVANYERL EFLGDAVLEL 70 80 90 100 110 120 VSTETLFTIH PDMTEGQLAK MRAKAVSEDA LSAIAKTKLK VGPYILLGHG EAEQGGAEKN 130 140 150 160 170 180 SILCDIVESL IGATFLEHGI DEARKVIHRL IDDTLAEVAT EGPALDWKTS LTVKAHGLGK 190 200 210 220 230 240 EEPVYHMEVS GPEYAQIFTA RVSLGENGDI IGIGKGSSKR KAQLAAAEAG WKSLDSFKTR TK

References

[1]

"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract." Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F. Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed: 12381787] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCC 2705.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014295 Genomic DNA. Translation: AAN24135.1. Different initiation.
RefSeq	NP_695499.1.
3D structure databases
HSSP	HSSP built from PDB template 1JFZ based on UniProtKB O67082.
ModBase	Search...
Genome annotation databases
GeneID	1022381.
GenomeReviews	Gene locus BL0295 in contig AE014295_GR.
KEGG	blo:BL0295.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8G7H1.
Enzyme and pathway databases
BioCyc	BLON206672:BL0295-MON.
BRENDA	3.1.26.3. 39917.
Family and domain databases
HAMAP	MF_00104. [Tree]
InterPro	IPR001159. Ds-RNA_bd. IPR014720. dsRNA-bd-like. IPR000999. RNase_III. IPR011907. RNase_III_bac. [Graphical view]
Gene3D	G3DSA:3.30.160.20. dsRNA-bd-like. 1 hit. G3DSA:1.10.1520.10. RNase_III. 1 hit.
Pfam	PF00035. dsrm. 1 hit. PF00636. Ribonuclease_3. 1 hit. [Graphical view]
SMART	SM00358. DSRM. 1 hit. SM00535. RIBOc. 1 hit. [Graphical view]
TIGRFAMs	TIGR02191. RNaseIII. 1 hit.
PROSITE	PS50137. DS_RBD. 1 hit. PS00517. RNASE_3_1. 1 hit. PS50142. RNASE_3_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNC_BIFLO

Accession

Primary (citable) accession number: Q8G7H1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	March 21, 2006
Last modified:	June 16, 2009
This is version 33 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)