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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei268ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLON206672:G1FZZ-1171-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:BL0469
OrganismiBifidobacterium longum (strain NCC 2705)
Taxonomic identifieri206672 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
Proteomesi
  • UP000000439 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001195151 – 506Glutamate--tRNA ligaseAdd BLAST506

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi206672.BL0469

Structurei

3D structure databases

ProteinModelPortaliQ8G709
SMRiQ8G709
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi21 – 31"HIGH" regionUniRule annotationAdd BLAST11
Motifi265 – 269"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK01885
OMAiHYINTLP
PhylomeDBiQ8G709

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
1.10.1160.10, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020061 Glu_tRNA_lig_a-bdl
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q8G709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDAENTKPE LPKNVRVRFC PSPTGTPHVG MIRTALFNWA EARATGGTLI
60 70 80 90 100
FRIEDTDAVR DSEESYNQIL ESLRWLGIDW DEGIDVGGPH GPYRQSERTA
110 120 130 140 150
IYKDVAAKLL EAGYAYESFS TPEEIKERNL AAGRPAEFGY DGYDRNLTDE
160 170 180 190 200
QKAAFRAEGR KPALRIKMPD EDIAFDDLIR GTIEFKAGSV PDYVIVRPNG
210 220 230 240 250
DPLYTLTNPV DDAMMEVNVV LRGEDLLSST PRQIVLYRYL MELGIAKEMP
260 270 280 290 300
LFGHMPYVMG QGNKKLSKRD PESNLFNHRD NGFIREGLLN YLALLGWSIA
310 320 330 340 350
PDRDVFSMDE MTEKFDVRDV KANPARFDID KAISINAEHI RMLEPEDFLR
360 370 380 390 400
RSVPYLHRDG VVSADNWDAL TDREREVLTA AAPLVQPRVR LLGEVAGMVG
410 420 430 440 450
SLLSTEGYLE PADDAKKQLK DSAGEVLDKA IAALEAVDEA DWKTDNLHET
460 470 480 490 500
LNKALVEEGG YKPRLAFGPV RVAMSGRRVS PPLFESMEIV GKPVSLARLK

GLREHL
Length:506
Mass (Da):56,681
Last modified:March 1, 2003 - v1
Checksum:i3FB6166D424431AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014295 Genomic DNA Translation: AAN24300.1
RefSeqiNP_695664.1, NC_004307.2
WP_007051591.1, NC_004307.2

Genome annotation databases

EnsemblBacteriaiAAN24300; AAN24300; BL0469
GeneIDi1023225
KEGGiblo:BL0469
PATRICifig|206672.9.peg.1212

Similar proteinsi

Entry informationi

Entry nameiSYE_BIFLO
AccessioniPrimary (citable) accession number: Q8G709
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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