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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLON206672:G1FZZ-1180-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:BL0478
OrganismiBifidobacterium longum (strain NCC 2705)
Taxonomic identifieri206672 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
Proteomesi
  • UP000000439 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001993361 – 505Formate--tetrahydrofolate ligaseAdd BLAST505

Proteomic databases

PRIDEiQ8G700

Interactioni

Protein-protein interaction databases

STRINGi206672.BL0478

Structurei

3D structure databases

ProteinModelPortaliQ8G700
SMRiQ8G700
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CKU Bacteria
COG2759 LUCA
HOGENOMiHOG000112304
KOiK01938
OMAiVDNYIYQ
PhylomeDBiQ8G700

Family and domain databases

InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8G700-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTIEDFTSQ YGLVQKIDAF GYMKYLAENP DAPRKHGKVV LVTADTPLKA
60 70 80 90 100
SRGEGKTTTT IALIDALNKR GIDATAVLRQ PSMGITAAGS KGGASGGGKA
110 120 130 140 150
SLTHPELIDW GLCGEMGAIE AAQNLLVSFA EKAIDDGKLD TILVPRVSEV
160 170 180 190 200
PSRSLRSTAV DYGKGNVPEK VVLTPTCELM QIVVLSRSMD EISERVSKMI
210 220 230 240 250
AGTKDGKAVT FGEFVDLWRI TGILADAVKP AKTETVNGSP VYVHGGPFAN
260 270 280 290 300
VSIGIPTLVS VEMACALHDV VIVEAGYGTD AGAQKWLDIA CREYGAQWPS
310 320 330 340 350
AAIVVTRAST WRDDPELAWR YPFHVQRLEN LDIPTFPLIN LWEGEDDQVP
360 370 380 390 400
SLKATADELG FRTPIIGNLF RDGGEALAPQ LDGFVDALQN GSMPAEPHSH
410 420 430 440 450
KGMALTENAK WVAENAYGVP AERVIYKPGF TESVSEAMEL CQSAGISLDD
460 470 480 490 500
LAFVAVKSPA TMTDNDRAPE EERTVALKKV EVHAGAGLVH VNLTTSLTTP

MPKIV
Length:505
Mass (Da):54,028
Last modified:March 1, 2003 - v1
Checksum:iB5643626B9884BC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014295 Genomic DNA Translation: AAN24309.1
RefSeqiNP_695673.1, NC_004307.2
WP_011068506.1, NC_004307.2

Genome annotation databases

EnsemblBacteriaiAAN24309; AAN24309; BL0478
GeneIDi1022163
KEGGiblo:BL0478
PATRICifig|206672.9.peg.1221

Similar proteinsi

Entry informationi

Entry nameiFTHS_BIFLO
AccessioniPrimary (citable) accession number: Q8G700
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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