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Q8G700 (FTHS_BIFLO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:BL0478
OrganismBifidobacterium longum (strain NCC 2705) [Reference proteome] [HAMAP]
Taxonomic identifier206672 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 505505Formate--tetrahydrofolate ligase
PRO_0000199336

Sequences

Sequence LengthMass (Da)Tools
Q8G700 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: B5643626B9884BC8

FASTA50554,028
        10         20         30         40         50         60 
MTTIEDFTSQ YGLVQKIDAF GYMKYLAENP DAPRKHGKVV LVTADTPLKA SRGEGKTTTT 

        70         80         90        100        110        120 
IALIDALNKR GIDATAVLRQ PSMGITAAGS KGGASGGGKA SLTHPELIDW GLCGEMGAIE 

       130        140        150        160        170        180 
AAQNLLVSFA EKAIDDGKLD TILVPRVSEV PSRSLRSTAV DYGKGNVPEK VVLTPTCELM 

       190        200        210        220        230        240 
QIVVLSRSMD EISERVSKMI AGTKDGKAVT FGEFVDLWRI TGILADAVKP AKTETVNGSP 

       250        260        270        280        290        300 
VYVHGGPFAN VSIGIPTLVS VEMACALHDV VIVEAGYGTD AGAQKWLDIA CREYGAQWPS 

       310        320        330        340        350        360 
AAIVVTRAST WRDDPELAWR YPFHVQRLEN LDIPTFPLIN LWEGEDDQVP SLKATADELG 

       370        380        390        400        410        420 
FRTPIIGNLF RDGGEALAPQ LDGFVDALQN GSMPAEPHSH KGMALTENAK WVAENAYGVP 

       430        440        450        460        470        480 
AERVIYKPGF TESVSEAMEL CQSAGISLDD LAFVAVKSPA TMTDNDRAPE EERTVALKKV 

       490        500 
EVHAGAGLVH VNLTTSLTTP MPKIV 

« Hide

References

[1]"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCC 2705.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014295 Genomic DNA. Translation: AAN24309.1.
RefSeqNP_695673.1. NC_004307.2.

3D structure databases

ProteinModelPortalQ8G700.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING206672.BL0478.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN24309; AAN24309; BL0478.
GeneID1022163.
KEGGblo:BL0478.
PATRIC21119545. VBIBifLon107831_1221.

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000112304.
KOK01938.
OMATVGHELM.
OrthoDBEOG6PCPSP.
ProtClustDBCLSK572650.

Enzyme and pathway databases

BioCycBLON206672:GI1E-1158-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_BIFLO
AccessionPrimary (citable) accession number: Q8G700
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways