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Q8G700

- FTHS_BIFLO

UniProt

Q8G700 - FTHS_BIFLO

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLON206672:GI1E-1158-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:BL0478
OrganismiBifidobacterium longum (strain NCC 2705)
Taxonomic identifieri206672 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000000439: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Formate--tetrahydrofolate ligasePRO_0000199336Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi206672.BL0478.

Structurei

3D structure databases

ProteinModelPortaliQ8G700.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000112304.
KOiK01938.
OMAiWDGEDDQ.
OrthoDBiEOG6PCPSP.
PhylomeDBiQ8G700.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G700-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTIEDFTSQ YGLVQKIDAF GYMKYLAENP DAPRKHGKVV LVTADTPLKA
60 70 80 90 100
SRGEGKTTTT IALIDALNKR GIDATAVLRQ PSMGITAAGS KGGASGGGKA
110 120 130 140 150
SLTHPELIDW GLCGEMGAIE AAQNLLVSFA EKAIDDGKLD TILVPRVSEV
160 170 180 190 200
PSRSLRSTAV DYGKGNVPEK VVLTPTCELM QIVVLSRSMD EISERVSKMI
210 220 230 240 250
AGTKDGKAVT FGEFVDLWRI TGILADAVKP AKTETVNGSP VYVHGGPFAN
260 270 280 290 300
VSIGIPTLVS VEMACALHDV VIVEAGYGTD AGAQKWLDIA CREYGAQWPS
310 320 330 340 350
AAIVVTRAST WRDDPELAWR YPFHVQRLEN LDIPTFPLIN LWEGEDDQVP
360 370 380 390 400
SLKATADELG FRTPIIGNLF RDGGEALAPQ LDGFVDALQN GSMPAEPHSH
410 420 430 440 450
KGMALTENAK WVAENAYGVP AERVIYKPGF TESVSEAMEL CQSAGISLDD
460 470 480 490 500
LAFVAVKSPA TMTDNDRAPE EERTVALKKV EVHAGAGLVH VNLTTSLTTP

MPKIV
Length:505
Mass (Da):54,028
Last modified:March 1, 2003 - v1
Checksum:iB5643626B9884BC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014295 Genomic DNA. Translation: AAN24309.1.
RefSeqiNP_695673.1. NC_004307.2.

Genome annotation databases

EnsemblBacteriaiAAN24309; AAN24309; BL0478.
GeneIDi1022163.
KEGGiblo:BL0478.
PATRICi21119545. VBIBifLon107831_1221.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014295 Genomic DNA. Translation: AAN24309.1 .
RefSeqi NP_695673.1. NC_004307.2.

3D structure databases

ProteinModelPortali Q8G700.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 206672.BL0478.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN24309 ; AAN24309 ; BL0478 .
GeneIDi 1022163.
KEGGi blo:BL0478.
PATRICi 21119545. VBIBifLon107831_1221.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000112304.
KOi K01938.
OMAi WDGEDDQ.
OrthoDBi EOG6PCPSP.
PhylomeDBi Q8G700.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci BLON206672:GI1E-1158-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
    Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
    Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCC 2705.

Entry informationi

Entry nameiFTHS_BIFLO
AccessioniPrimary (citable) accession number: Q8G700
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3