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Q8G700

- FTHS_BIFLO

UniProt

Q8G700 - FTHS_BIFLO

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBLON206672:GI1E-1158-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligase (EC:6.3.4.3)
    Alternative name(s):
    Formyltetrahydrofolate synthetase
    Short name:
    FHS
    Short name:
    FTHFS
    Gene namesi
    Name:fhs
    Ordered Locus Names:BL0478
    OrganismiBifidobacterium longum (strain NCC 2705)
    Taxonomic identifieri206672 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000000439: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 505505Formate--tetrahydrofolate ligasePRO_0000199336Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi206672.BL0478.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G700.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000112304.
    KOiK01938.
    OMAiWDGEDDQ.
    OrthoDBiEOG6PCPSP.
    PhylomeDBiQ8G700.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8G700-1 [UniParc]FASTAAdd to Basket

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    MTTIEDFTSQ YGLVQKIDAF GYMKYLAENP DAPRKHGKVV LVTADTPLKA    50
    SRGEGKTTTT IALIDALNKR GIDATAVLRQ PSMGITAAGS KGGASGGGKA 100
    SLTHPELIDW GLCGEMGAIE AAQNLLVSFA EKAIDDGKLD TILVPRVSEV 150
    PSRSLRSTAV DYGKGNVPEK VVLTPTCELM QIVVLSRSMD EISERVSKMI 200
    AGTKDGKAVT FGEFVDLWRI TGILADAVKP AKTETVNGSP VYVHGGPFAN 250
    VSIGIPTLVS VEMACALHDV VIVEAGYGTD AGAQKWLDIA CREYGAQWPS 300
    AAIVVTRAST WRDDPELAWR YPFHVQRLEN LDIPTFPLIN LWEGEDDQVP 350
    SLKATADELG FRTPIIGNLF RDGGEALAPQ LDGFVDALQN GSMPAEPHSH 400
    KGMALTENAK WVAENAYGVP AERVIYKPGF TESVSEAMEL CQSAGISLDD 450
    LAFVAVKSPA TMTDNDRAPE EERTVALKKV EVHAGAGLVH VNLTTSLTTP 500
    MPKIV 505
    Length:505
    Mass (Da):54,028
    Last modified:March 1, 2003 - v1
    Checksum:iB5643626B9884BC8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014295 Genomic DNA. Translation: AAN24309.1.
    RefSeqiNP_695673.1. NC_004307.2.

    Genome annotation databases

    EnsemblBacteriaiAAN24309; AAN24309; BL0478.
    GeneIDi1022163.
    KEGGiblo:BL0478.
    PATRICi21119545. VBIBifLon107831_1221.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014295 Genomic DNA. Translation: AAN24309.1 .
    RefSeqi NP_695673.1. NC_004307.2.

    3D structure databases

    ProteinModelPortali Q8G700.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 206672.BL0478.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN24309 ; AAN24309 ; BL0478 .
    GeneIDi 1022163.
    KEGGi blo:BL0478.
    PATRICi 21119545. VBIBifLon107831_1221.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000112304.
    KOi K01938.
    OMAi WDGEDDQ.
    OrthoDBi EOG6PCPSP.
    PhylomeDBi Q8G700.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci BLON206672:GI1E-1158-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
      Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
      Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCC 2705.

    Entry informationi

    Entry nameiFTHS_BIFLO
    AccessioniPrimary (citable) accession number: Q8G700
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3