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Reviewed, UniProtKB/Swiss-Prot Q8G6V2 (ILVC1_BIFLO)

Last modified February 9, 2010. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Ketol-acid reductoisomerase 1
    EC=1.1.1.86
Alternative name(s):
    Acetohydroxy-acid isomeroreductase 1
    Alpha-keto-beta-hydroxylacil reductoisomerase 1
Gene names
Name: ilvC1
Ordered Locus Names: BL0530
OrganismBifidobacterium longum [Complete proteome] [HAMAP]
Taxonomic identifier216816 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Ketol-acid reductoisomerase 1 HAMAP MF_00435
PRO_0000151278

Sites

Active site1091 Potential

Sequences

Sequence LengthMass (Da)Tools
Q8G6V2-1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: FD3E3B700BF65247

FASTA35038,560
        10         20         30         40         50         60 
MAAQIWYEND GDLSVLEGKK VAIIGYGSQG HAHALNLRDS GVDVVVGLRP TSKSVDFAKE 

        70         80         90        100        110        120 
QGLEVKSVAE ASAEADVIMI LAPDQYQRTI WANDIEPNIK PGAAVAFAHG FNIHYGYIKP 

       130        140        150        160        170        180 
SEDHPVFMVA PKGPGHIVRR EYAAGRGVPV VVAVEQDPRG DGWALTLAYA KALGALRAGA 

       190        200        210        220        230        240 
IKTTFKEETE TDLFGEQNVL MGGVNKLVEM GFEVLTDAGY QPEIAYFEVC HELKMLVDLM 

       250        260        270        280        290        300 
NEGGLNKARW SCSDTAQYGD YVNTVINEDC RKRMEYHLQR IQDGSFAKEF IDDQDAGAPH 

       310        320        330        340        350 
FKELQEKYSN ERIETVGPKL RAMFSWNKDG VKDADEANSF TGKIARAQVQ 

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References

[1]"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed: 12381787] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCC 2705.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014295 Genomic DNA. Translation: AAN24357.1. Different initiation.
RefSeqNP_695721.1.

3D structure databases

SMRQ8G6V2. Positions 4-326.
ModBaseSearch...

Genome annotation databases

GeneID1023093.
GenomeReviewsGene locus BL0530 in contig AE014295_GR.
KEGGblo:BL0530.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG286525.
OMADSISNTA.
PhylomeDBQ8G6V2.

Enzyme and pathway databases

BioCycBLON206672:BL0530-MONOMER.
BRENDA1.1.1.86. 39917.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013116. IlvN.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
TIGRFAMsTIGR00465. ilvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC1_BIFLO
AccessionPrimary (citable) accession number: Q8G6V2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 17, 2006
Last modified: February 9, 2010
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents