Q8G6T7 (HTPX_BIFLO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protease HtpX homolog
EC=3.4.24.-

Gene names

Name:	htpX
Ordered Locus Names:	BL0551

Organism

Bifidobacterium longum (strain NCC 2705) [Reference proteome] [HAMAP]

Taxonomic identifier

206672 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium › Bifidobacterium longum

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00188
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00188.
Sequence similarities	Belongs to the peptidase M48B family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Protease HtpX homolog HAMAP-Rule MF_00188		PRO_0000138853
Regions
	Transmembrane	10 – 30	21	Helical; Potential
	Transmembrane	33 – 53	21	Helical; Potential
	Transmembrane	149 – 169	21	Helical; Potential
	Transmembrane	181 – 201	21	Helical; Potential
Sites
	Active site	136	1	By similarity
	Metal binding	135	1	Zinc; catalytic By similarity
	Metal binding	139	1	Zinc; catalytic By similarity
	Metal binding	210	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8G6T7 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 0A8BE26488FB8B3B	FASTA	306	33,100
	10 20 30 40 50 60 MHGHFNGLKT TLLFALMWAI IMLIWWATGG SRQTLSIYIV IGLITTFGTY WFSDKLAIAS 70 80 90 100 110 120 MGAREVSEQE APEIYQIVRE LSAKAGKPMP RIYIAPTMSP NAFATGRNER HAAVCCTQGI 130 140 150 160 170 180 LQILNARELR GVLGHELMHV YNHDILTSAI ASAMATVISY LGYSLMYFGG GSRDDRDSSG 190 200 210 220 230 240 GLGLIGALLS VILAPIAASL IQMAISRTRE YDADEDGSLL TGDPEALASA LNKISYGAQT 250 260 270 280 290 300 TPMRKTAGTQ SVSAMMIANP FSAVGFSRLF STHPPTDERI ARLMQMANEM NGTPIAPPTY STRVGR

References

[1]

"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract." Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F. Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCC 2705.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014295 Genomic DNA. Translation: AAN24375.1.
RefSeq	NP_695739.1. NC_004307.2.
3D structure databases
ProteinModelPortal	Q8G6T7.
ModBase	Search...
Protein-protein interaction databases
STRING	206672.BL0551.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN24375; AAN24375; BL0551.
GeneID	1023260.
KEGG	blo:BL0551.
PATRIC	21119695. VBIBifLon107831_1295.
Phylogenomic databases
eggNOG	COG0501.
HOGENOM	HOG000227301.
KO	K03799.
OMA	QTTPMRK.
ProtClustDB	PRK03072.
Enzyme and pathway databases
BioCyc	BLON206672:GI1E-1223-MONOMER.
Family and domain databases
HAMAP	MF_00188. Peptidase_M48.
InterPro	IPR022919. Pept_M48_protease_HtpX. IPR001915. Peptidase_M48. [Graphical view]
Pfam	PF01435. Peptidase_M48. 1 hit. [Graphical view]
PROSITE	PS00142. ZINC_PROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HTPX_BIFLO

Accession

Primary (citable) accession number: Q8G6T7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	March 1, 2003
Last modified:	May 29, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program