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Q8G6P9

- PKNB_BIFLO

UniProt

Q8G6P9 - PKNB_BIFLO

Protein

Probable serine/threonine-protein kinase PknB

Gene

pknB

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431ATPPROSITE-ProRule annotation
    Active sitei146 – 1461Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi20 – 289ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. penicillin binding Source: InterPro
    3. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBLON206672:GI1E-1262-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable serine/threonine-protein kinase PknB (EC:2.7.11.1)
    Gene namesi
    Name:pknB
    Ordered Locus Names:BL0589
    OrganismiBifidobacterium longum (strain NCC 2705)
    Taxonomic identifieri206672 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000000439: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 690690Probable serine/threonine-protein kinase PknBPRO_0000171185Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi206672.BL0589.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G6P9.
    SMRiQ8G6P9. Positions 6-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 285272Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini399 – 46769PASTA 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini468 – 53669PASTA 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini540 – 60162PASTA 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini602 – 66665PASTA 4PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi667 – 68923Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 4 PASTA domains.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000037185.
    KOiK08884.
    OMAiMSKNPAN.
    OrthoDBiEOG6B35XT.
    PhylomeDBiQ8G6P9.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR005543. PASTA_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF03793. PASTA. 4 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00740. PASTA. 4 hits.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51178. PASTA. 4 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8G6P9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTSMPTALA GGRYQLGQLI GRGGMAEVHV ALDTRLGRTV AVKIMRADLA    50
    NDDIFLARFR REAHAVAQMN NPNIVNIYDS GEELVSSESG DAERLPYIVM 100
    EYVKGQTLRD IIKVNGALSQ RDCEQVMLGV LNALDYSHRM GIIHRDIKPG 150
    NIMISEQGVV KVMDFGIARA LDDSAATMTQ SQGVVGTAQY LSPEQARGET 200
    VDMRSDLYSA GCVLYEMLTG RPPFTGDSAV AIAYQHVSEV ATPPSAAVPG 250
    LPKMWDSICA KAMAKDRQNR YATASEFKTD ILTYMNGGVP VAAAFNPLTD 300
    LSNMKARKEA ERDLPTTPVE PHQQPTQAFN PVTGQFEQIP PANGANAAAL 350
    QSRAQQRAAA AKAKKRKKII IGSVIAAIVA VLVIVGIVFA MNGSGNKSSE 400
    DTVTIPEVCN ASTSKDNIKL KLEASGLKMT EKQDTDSTEP EGTCTKMSPD 450
    AGSKVAKGSA VKVWFSAGPQ STQVPDVKER SQEEARSILE SAGFKVNAAV 500
    KTEDSADIAK DMVTKTDPAA GQSVPKGTTI TIYVSSGMTT VPSNLVGQSK 550
    DSVLQQYEGK FSFTVEQESS DTVEAGLITR VSPDSGSSIA QGGFITIWVS 600
    TGKEKVAVPN ITAGTDYVTA ELMLKAVGLK AQANGPTGST AVVVSINPGA 650
    GSQVDAGSTV TITTKAGSTG GGTGTGDGGN GTGNGGGTGE 690
    Length:690
    Mass (Da):72,244
    Last modified:March 1, 2003 - v1
    Checksum:i6A419EA8CED5D92D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014295 Genomic DNA. Translation: AAN24413.1.
    RefSeqiNP_695777.1. NC_004307.2.

    Genome annotation databases

    EnsemblBacteriaiAAN24413; AAN24413; BL0589.
    GeneIDi1022968.
    KEGGiblo:BL0589.
    PATRICi21119765. VBIBifLon107831_1329.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014295 Genomic DNA. Translation: AAN24413.1 .
    RefSeqi NP_695777.1. NC_004307.2.

    3D structure databases

    ProteinModelPortali Q8G6P9.
    SMRi Q8G6P9. Positions 6-290.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 206672.BL0589.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN24413 ; AAN24413 ; BL0589 .
    GeneIDi 1022968.
    KEGGi blo:BL0589.
    PATRICi 21119765. VBIBifLon107831_1329.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000037185.
    KOi K08884.
    OMAi MSKNPAN.
    OrthoDBi EOG6B35XT.
    PhylomeDBi Q8G6P9.

    Enzyme and pathway databases

    BioCyci BLON206672:GI1E-1262-MONOMER.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR005543. PASTA_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF03793. PASTA. 4 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00740. PASTA. 4 hits.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51178. PASTA. 4 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
      Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
      Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCC 2705.

    Entry informationi

    Entry nameiPKNB_BIFLO
    AccessioniPrimary (citable) accession number: Q8G6P9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3