ID   Q8G6I0_BIFLO            Unreviewed;       746 AA.
AC   Q8G6I0;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 130.
DE   SubName: Full=Widely conserved protein with eukaryotic protein kinase domain {ECO:0000313|EMBL:AAN24482.1};
GN   OrderedLocusNames=BL0660 {ECO:0000313|EMBL:AAN24482.1};
OS   Bifidobacterium longum (strain NCC 2705).
OC   Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC   Bifidobacteriaceae; Bifidobacterium.
OX   NCBI_TaxID=206672 {ECO:0000313|EMBL:AAN24482.1, ECO:0000313|Proteomes:UP000000439};
RN   [1] {ECO:0000313|EMBL:AAN24482.1, ECO:0000313|Proteomes:UP000000439}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCC 2705 {ECO:0000313|Proteomes:UP000000439};
RX   PubMed=12381787; DOI=10.1073/pnas.212527599;
RA   Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G.,
RA   Zwahlen M.C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.;
RT   "The genome sequence of Bifidobacterium longum reflects its adaptation to
RT   the human gastrointestinal tract.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE014295; AAN24482.1; -; Genomic_DNA.
DR   RefSeq; NP_695846.1; NC_004307.2.
DR   AlphaFoldDB; Q8G6I0; -.
DR   STRING; 206672.BL0660; -.
DR   EnsemblBacteria; AAN24482; AAN24482; BL0660.
DR   KEGG; blo:BL0660; -.
DR   PATRIC; fig|206672.9.peg.1391; -.
DR   HOGENOM; CLU_000288_135_6_11; -.
DR   OrthoDB; 9762169at2; -.
DR   Proteomes; UP000000439; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR24347:SF412; CALCIUM_CALMODULIN DEPENDENT PROTEIN KINASE I; 1.
DR   PANTHER; PTHR24347; SERINE/THREONINE-PROTEIN KINASE; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:AAN24482.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000000439};
KW   Transferase {ECO:0000313|EMBL:AAN24482.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        542..562
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        603..628
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        648..669
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        718..740
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          28..298
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          68..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          447..476
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        458..473
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         56
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   746 AA;  77844 MW;  4A62BA752E69A034 CRC64;
     MHQQGIRMEG MSDLNALNLE SGEVVGGYTL ISRLGSGAMG SVWRVRDDGG TTYAMKILRD
     SLTDESVAGS GSASTALHDP DLKPDVTPRE RLRREAMALK KVNHPGVCGI VDMELDDTLA
     FIVTELIEGK NLKDDVAANG RYVGDDLERL ARKLIEATKA VHAAGIVHRD IKPTNVMVSA
     AGPVLVDFGI AMGEGESHVT RTGLVMGTPG FIAPEIIDGA ESDDATDWWS VASVLAFAAT
     GAPVFGTKPM MAVLEREASG NANLSGLPAG TLAAFRSALD PDRRDRCTPD QLLNAIALDA
     LNPNAWQGEQ AGPFAAGAVA GQPAAIVAEA AEAMPPFGAA GGVDRNNPRT IWRAAEEAAE
     APTMAVFSGN KGDNGDGETV VFSPAGAATA TLPLADMPPR PPAGAEQATQ LLPDAAADFT
     DDAGTQVLTG ATTPMPDQTT PLAERTTVLP TPQPSSFPPS GTAQSSWDPA SNQPTAVDPA
     IRPALQRIID QTAQAAPTET MVQNPPMPNP VDVKRGEYLQ RGTLPLILLA APLAALAANA
     PLVAIIAATA LLWLLLTLAY NTEPQLEREG KRGGERKNSD SWIRVATFPW HLVKALLLAI
     PRILLLVIIY MAGTAVATAA LALPVHTISW YFTADWGIPV PLLNDVPFSA SGLALGGFMA
     IGWLVTVFVP QSMMIRLGGG VLRGLKHSRP AGAPSTEVGG APPAPVAPAP KGGGRGTVLF
     TIWAIITVAL CAMPILGMPI NWMPFA
//