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Q8G6C4 (UPPP_BIFLO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:BL0721
OrganismBifidobacterium longum (strain NCC 2705) [Reference proteome] [HAMAP]
Taxonomic identifier206672 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151112

Regions

Transmembrane39 – 5921Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane123 – 14321Helical; Potential
Transmembrane198 – 21821Helical; Potential
Transmembrane232 – 25221Helical; Potential
Transmembrane268 – 28821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q8G6C4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: F8D0C072089FD198

FASTA29431,977
        10         20         30         40         50         60 
MNFFQAIILG IVQALTEYLP VSSSAHIRIF GDLMLGSDPG AAFTAIIQIG TELAVILYFR 

        70         80         90        100        110        120 
HDIINILTHW FSCLFGKNGK DWKARMGRGD NYATLGWNII VGSIPIIILG FTLQNVIETS 

       130        140        150        160        170        180 
LRNLWITVTV LLVFGILLWM VDAKARQNKT MNDMTYRDAF LFGLGQSMAL IPGVSRSGGT 

       190        200        210        220        230        240 
ITVGRALGYT REAAVRLSFL MAIPAVFGSG LLEAIKAVKN YKTDAMFPGW GPTLVAMVIS 

       250        260        270        280        290 
FVLGYIVIIG FLKFVSNFSY KAFAIYRIGL AVVVALLLIV GVLPAIDPSV VAAA 

« Hide

References

[1]"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCC 2705.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014295 Genomic DNA. Translation: AAN24539.1.
RefSeqNP_695903.1. NC_004307.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING206672.BL0721.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN24539; AAN24539; BL0721.
GeneID1023136.
KEGGblo:BL0721.
PATRIC21117881. VBIBifLon107831_0419.

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAIEGPFRD.
OrthoDBEOG6QP13M.
PhylomeDBQ8G6C4.

Enzyme and pathway databases

BioCycBLON206672:GI1E-384-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_BIFLO
AccessionPrimary (citable) accession number: Q8G6C4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families