Q8G6C4 (UPPP_BIFLO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Synonyms:	bacA, upk
Ordered Locus Names:	BL0721

Organism

Bifidobacterium longum (strain NCC 2705) [Reference proteome] [HAMAP]

Taxonomic identifier

206672 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium › Bifidobacterium longum

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000151112
Regions
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	93 – 113	21	Helical; Potential
	Transmembrane	123 – 143	21	Helical; Potential
	Transmembrane	198 – 218	21	Helical; Potential
	Transmembrane	232 – 252	21	Helical; Potential
	Transmembrane	268 – 288	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8G6C4 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: F8D0C072089FD198	FASTA	294	31,977
	10 20 30 40 50 60 MNFFQAIILG IVQALTEYLP VSSSAHIRIF GDLMLGSDPG AAFTAIIQIG TELAVILYFR 70 80 90 100 110 120 HDIINILTHW FSCLFGKNGK DWKARMGRGD NYATLGWNII VGSIPIIILG FTLQNVIETS 130 140 150 160 170 180 LRNLWITVTV LLVFGILLWM VDAKARQNKT MNDMTYRDAF LFGLGQSMAL IPGVSRSGGT 190 200 210 220 230 240 ITVGRALGYT REAAVRLSFL MAIPAVFGSG LLEAIKAVKN YKTDAMFPGW GPTLVAMVIS 250 260 270 280 290 FVLGYIVIIG FLKFVSNFSY KAFAIYRIGL AVVVALLLIV GVLPAIDPSV VAAA

References

[1]

"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract." Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F. Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCC 2705.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014295 Genomic DNA. Translation: AAN24539.1.
RefSeq	NP_695903.1. NC_004307.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	206672.BL0721.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN24539; AAN24539; BL0721.
GeneID	1023136.
KEGG	blo:BL0721.
PATRIC	21117881. VBIBifLon107831_0419.
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	HLAIFTA.
ProtClustDB	PRK12554.
Enzyme and pathway databases
BioCyc	BLON206672:GI1E-384-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_BIFLO

Accession

Primary (citable) accession number: Q8G6C4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	March 1, 2003
Last modified:	May 29, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program