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Q8G6B1

- PUR9_BIFLO

UniProt

Q8G6B1 - PUR9_BIFLO

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, BL0735
Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciBLON206672:GI1E-402-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:BL0735
OrganismiBifidobacterium longum (strain NCC 2705)
Taxonomic identifieri206672 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000000439: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 545545Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_0000192072Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi206672.BL0735.

Structurei

3D structure databases

ProteinModelPortaliQ8G6B1.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiHRRAHAC.
OrthoDBiEOG6QCDFF.
PhylomeDBiQ8G6B1.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8G6B1-1 [UniParc]FASTAAdd to Basket

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MTNTNRPIRR ALVSVFHKEG IEVLAEAFVK AGTEVVSTGS TAKKLAELGV    50
KVTEVSDVTG FPECLDGRVK TLHPYIHAGI LADMTNPEHA KQLEEFGIKP 100
FDLVVVNLYP FADTVRSGAN EADTIEKIDI GGPSMVRGAA KNHATVAIVT 150
DPADYALVAS RVADGTGFSL DERKWLAAKA FAHTAAYDAT INEWTAKHWP 200
KPASLDAVEV DKDDQGTEVD PAKFPAQFTR TWDRAHTLRY GENSHQQAAL 250
YIDPLNQTGF AHAEQLGGKP MSYNNYVDAD AAWRTVWDMA PAIAVAVVKH 300
NNPCGLAIGA TAAEAHKKAH ACDPMSAYGG VIACNSKVTL EMAESVRPIF 350
TEVIVAPDYE PAALELLQTK KKNLRILEVA EPPKGHEAIR QIDGGLLVQD 400
TDLINAVGDD PDAWKLVAGE AADADTLKDL VFAWRAIRCV KSNAILLAHD 450
QATVGIGMGQ VNRVDSCHLA VERANTLADG ADRATGAVAA SDAFFPFADG 500
AQVLIDAGVK AIVQPGGSIR DEEVIEAAKK AGVTMYLTGT RHFFH 545
Length:545
Mass (Da):58,413
Last modified:March 1, 2003 - v1
Checksum:i45EC500131DFA331
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014295 Genomic DNA. Translation: AAN24552.1.
RefSeqiNP_695916.1. NC_004307.2.

Genome annotation databases

EnsemblBacteriaiAAN24552; AAN24552; BL0735.
GeneIDi1021781.
KEGGiblo:BL0735.
PATRICi21117917. VBIBifLon107831_0432.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014295 Genomic DNA. Translation: AAN24552.1 .
RefSeqi NP_695916.1. NC_004307.2.

3D structure databases

ProteinModelPortali Q8G6B1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 206672.BL0735.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN24552 ; AAN24552 ; BL0735 .
GeneIDi 1021781.
KEGGi blo:BL0735.
PATRICi 21117917. VBIBifLon107831_0432.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi HRRAHAC.
OrthoDBi EOG6QCDFF.
PhylomeDBi Q8G6B1.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci BLON206672:GI1E-402-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
    Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
    Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCC 2705.

Entry informationi

Entry nameiPUR9_BIFLO
AccessioniPrimary (citable) accession number: Q8G6B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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