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Q8G661 (PYRE_BIFLO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase
Short name=OPRT
Short name=OPRTase
EC=2.4.2.10
Gene names
Name:pyrE
Ordered Locus Names:BL0788
OrganismBifidobacterium longum (strain NCC 2705)
Taxonomic identifier206672 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity. HAMAP MF_01208

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 231231Orotate phosphoribosyltransferase HAMAP MF_01208
PRO_0000110674

Regions

Region79 – 8025-phosphoribose 1-diphosphate binding By similarity
Region133 – 14195-phosphoribose 1-diphosphate binding By similarity

Sites

Binding site2715-phosphoribose 1-diphosphate By similarity
Binding site10615-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site10715-phosphoribose 1-diphosphate By similarity
Binding site11015-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site11215-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site1371Orotate By similarity
Binding site1661Orotate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8G661 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: C369804E8499103F

FASTA23124,944
        10         20         30         40         50         60 
MAETLAHRFT EFLLESNALK FGDFTLKSGR KSPYFINAGA FDDGKKIAAL GAFYAEKISQ 

        70         80         90        100        110        120 
AIVHNTIPRN IDTVFGPAYK GIPLAVSTAI ALTAGHNMTV GYTFDRKEKK DHGDGGWMVG 

       130        140        150        160        170        180 
TPLTDGMKVL LVDDVMTAGT AVREVIPKLK AEANVEVVGL VLSVDRMEKT KDSDMSAVKA 

       190        200        210        220        230 
VEAEFGFPVL SIANVREIFD AAAKMKNPDG TPLLSHDIQQ RAAAYLEEYG A

« Hide

References

[1]"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed: 12381787] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCC 2705.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014295 Genomic DNA. Translation: AAN24603.1.
RefSeqNP_695967.1. NC_004307.2.

3D structure databases

ProteinModelPortalQ8G661.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1022074.
GenomeReviewsGene locus BL0788 in contig AE014295_GR.
KEGGblo:BL0788.
NMPDRfig|206672.1.peg.734.
PATRIC21118031. VBIBifLon107831_0489.

Phylogenomic databases

HOGENOMHBG404341.
OMAFAFNRKE.
PhylomeDBQ8G661.
ProtClustDBPRK00455.

Enzyme and pathway databases

BioCycBLON206672:BL0788-MONOMER.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRE_BIFLO
AccessionPrimary (citable) accession number: Q8G661
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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