Q8G657 (Q8G657_BIFLO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Dihydroorotase EMBL AAN24607.1

Gene names

Name:	pyrC EMBL AAN24607.1
Ordered Locus Names:	BL0792

Organism

Bifidobacterium longum (strain NCC 2705)

Taxonomic identifier

206672 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. SAAS SAAS002195
Cofactor	Binds 2 zinc ions per subunit By similarity. SAAS SAAS002195
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. SAAS SAAS002195
Subunit structure	Homodimer By similarity. SAAS SAAS002195
Sequence similarities	Belongs to the DHOase family. RuleBase RU004949

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis SAAS SAAS002195
Ligand	Metal-binding SAAS SAAS002195 RuleBase RU004949 Zinc SAAS SAAS002195
Molecular function	Hydrolase SAAS SAAS002195 RuleBase RU004949
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8G657 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 64E474AF150CB28E	FASTA	498	53,254
	10 20 30 40 50 60 MSITLRNIKV WNTGEVIDLV VPGTAAAYFA DTSVVADGAD IDATGLTVAP GFEDPHVHFR 70 80 90 100 110 120 DPGQTYKESM VSGCRASASG GYTNVLIMPN TLPALDGQTV SGPEATGAKE VLDAGFDNVI 130 140 150 160 170 180 DFLQQYDTAH DVQLPVRYDL CVCASKDRAG HEASDVADWL KYVPGFEDDA KTPAMLTHPI 190 200 210 220 230 240 TAISDDGSAV TPEILDQVLE NVKASDLYLI EHCEHHDTGA VNEGPVSREL GVPGIPEDTE 250 260 270 280 290 300 LKIVARDIEA ARRTGVHVHF QHVSTAISFE AIRRAKAEGL PITCETAPHY LALSDEALLK 310 320 330 340 350 360 YGTLAKMNPP LRSEADRKAT IAAIADGTVD LLATDHAPHT LAEKELGFLE APNGIIGLEC 370 380 390 400 410 420 AYGVCHKVLV DGGFISDERL IELMSVGPAE LMGHVPTDVA ALVEDYAEPA PTGDDPDGVI 430 440 450 460 470 480 AGESDAQPQR EGVNRLLDLS RVDDADNVDL VVLNAAEEWT VDPEQFHSKA RNTPFGGWQV 490 TGRPLATIIG SQLMFSRL

References

[1]

"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract." Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F. Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed: 12381787] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCC 2705.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014295 Genomic DNA. Translation: AAN24607.1.
RefSeq	NP_695971.1. NC_004307.2.
3D structure databases
ProteinModelPortal	Q8G657.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1022088.
GenomeReviews	Gene locus BL0792 in contig AE014295_GR.
KEGG	blo:BL0792.
NMPDR	fig|206672.1.peg.738.
PATRIC	21118039. VBIBifLon107831_0493.
Phylogenomic databases
HOGENOM	HBG724623.
OMA	CDVHPVG.
PhylomeDB	Q8G657.
ProtClustDB	CLSK572777.
Family and domain databases
HAMAP	MF_00220_B. PyrC_type2_B. [Tree]
InterPro	IPR006680. Amidohydro_1. IPR004722. DHOase. IPR002195. Dihydroorotase_CS. IPR011059. Metal-dep_hydrolase_composite. [Graphical view]
KO	K01465.
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
SUPFAM	SSF51338. Metalo_hydrolase. 1 hit.
PROSITE	PS00482. DIHYDROOROTASE_1. 1 hit. PS00483. DIHYDROOROTASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8G657_BIFLO

Accession

Primary (citable) accession number: Q8G657

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)