Reviewed, UniProtKB/Swiss-Prot Q8G655 (PYRB_BIFLO)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	BL0794

Organism

Bifidobacterium longum [Complete proteome] [HAMAP]

Taxonomic identifier

216816 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 320	320	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000113103

Sequences

	Sequence		Length	Mass (Da)
	Q8G655-1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: AEC328C7F9EFA0DC	FASTA	320	35,264
	10 20 30 40 50 60 MVGKSVVTLD GLSTNQILDL LHKAEYIDSH RKEIAHTCDG RVLATLFYEP STRTRLSFET 70 80 90 100 110 120 AMLRLGGKVI GFAGAQLASV TKGESIADTL KTVSNYVDVV AIRHPKEGAA LVASRAASVP 130 140 150 160 170 180 VINAGDGGHM HPTQTLADLA TLQSRFGRIT DLTVGLCGDL TFGRTVHSLI ETLCRFGNVR 190 200 210 220 230 240 FVLISPDELK TPQYVIDRIN ATDSCSYVEV RDLASVIGDL DVLYMTRVQK ERFFNEDDYL 250 260 270 280 290 300 RLRDTYILDE EKLQLAKPSM AVLHPLPRVN EIAVDVDDDP RAAYFEQVKN GMLVRMALES 310 320 TVVGDELPGY EPLNPKEVQA

References

[1]

"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract." Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F. Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed: 12381787] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCC 2705.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014295 Genomic DNA. Translation: AAN24609.1. Different initiation.
RefSeq	NP_695973.1.
3D structure databases
HSSP	HSSP built from PDB template 1ML4 based on UniProtKB P77918.
ModBase	Search...
Genome annotation databases
GeneID	1022093.
GenomeReviews	Gene locus BL0794 in contig AE014295_GR.
KEGG	blo:BL0794.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8G655.
Enzyme and pathway databases
BioCyc	BLON206672:BL0794-MON.
BRENDA	2.1.3.2. 39917.
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Aspartate_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_BIFLO

Accession

Primary (citable) accession number: Q8G655

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	February 26, 2008
Last modified:	March 3, 2009
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)