Q8G652 (Q8G652_BIFLO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

Name:	metF EMBL AAN24612.1
Ordered Locus Names:	BL0797

Organism

Bifidobacterium longum (strain NCC 2705)

Taxonomic identifier

206672 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU004255
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004255
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8G652 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 40CA848CEBD0F1BC	FASTA	284	31,477
	10 20 30 40 50 60 MHSPMFTLEV FPPKRNAPVG TIYDTLDGLE GLNPDFISVT YGHGTHSDRT ATARIAHTIS 70 80 90 100 110 120 KEYGIPAVAH LTALYSDKAK IDEALDMFEE AGVSAVLALR GDYIDGEQLV GEFNHASDLV 130 140 150 160 170 180 SYIRSVKPDF KVFGACYPEG HYQADSLDQD IENLKIKVDA GVTHLISQLF YDNEDFYRFL 190 200 210 220 230 240 DKARAAGITV PIEAGIMPVR GAKSVRRMAE RNASRIPDRL NTLLNKWGDD IQSLRAAGIL 250 260 270 280 YASEQIADLV AHDVDGVHLY SMNHPATTRR IWRNAEPLFR GTQG

References

[1]

"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract." Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F. Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed: 12381787] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCC 2705.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014295 Genomic DNA. Translation: AAN24612.1.
RefSeq	NP_695976.1. NC_004307.2.
3D structure databases
HSSP	HSSP built from PDB template 1B5T based on UniProtKB P00394.
ProteinModelPortal	Q8G652.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1022117.
GenomeReviews	Gene locus BL0797 in contig AE014295_GR.
KEGG	blo:BL0797.
PATRIC	21118049. VBIBifLon107831_0498.
Phylogenomic databases
HOGENOM	HBG649727.
OMA	ITQMFFD.
PhylomeDB	Q8G652.
ProtClustDB	CLSK638816.
Family and domain databases
InterPro	IPR003171. Mehydrof_redctse. IPR004620. MTHF_reductase_bac. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00676. Fadh2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q8G652_BIFLO

Accession

Primary (citable) accession number: Q8G652

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)