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Q8G5X3 (AROC_BIFLO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:BL0878
OrganismBifidobacterium longum (strain NCC 2705)
Taxonomic identifier206672 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Subunit structure

Homotetramer By similarity. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395Chorismate synthase HAMAP MF_00300
PRO_0000140556

Sequences

Sequence LengthMass (Da)Tools
Q8G5X3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: E6EC2F9F3BBBC6D6

FASTA39542,363
        10         20         30         40         50         60 
MLRWQTAGES HGEALVAMIE GLPAGVRIST DDIVSALARR RLGYGRGARM KFEQDKVRLL 

        70         80         90        100        110        120 
TGVRHGLTLG SPVAIEIANT EWPKWTEVMS ADALDHDLPR EGRNAPLSRP RPGHADLTGM 

       130        140        150        160        170        180 
RKYGFDDARP VLERSSARET ASRVALGEVA KQFLDQAFGI RTVAHVVALG GVQTNPDLPL 

       190        200        210        220        230        240 
PTPDDLEALD ASPVRTLDKE AEARIIERIN EAKKASDTLG GVIEVLAYGV PAGIGTYVES 

       250        260        270        280        290        300 
DRRLDAALAS AIMGIQAFKG VEIGDGFLEA SRPGSQAHDE IVVNADGRID RLSNRAGGIE 

       310        320        330        340        350        360 
GGMSNGQVIR VRGAMKPIPS IPKALRTVDV LTGESAQAIN QRSDSTAVPA ASVVAEAMVR 

       370        380        390 
LTLAKYALDK FGGDSVAETR RNLESYLASW PEHMR

« Hide

References

[1]"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed: 12381787] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCC 2705.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014295 Genomic DNA. Translation: AAN24691.1.
RefSeqNP_696055.1. NC_004307.2.

3D structure databases

ProteinModelPortalQ8G5X3.
SMRQ8G5X3. Positions 1-389.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1022375.
GenomeReviewsGene locus BL0878 in contig AE014295_GR.
KEGGblo:BL0878.
PATRIC21118203. VBIBifLon107831_0574.

Phylogenomic databases

HOGENOMHBG292336.
OMAMLRWLTA.
PhylomeDBQ8G5X3.
ProtClustDBPRK05382.

Enzyme and pathway databases

BioCycBLON206672:BL0878-MONOMER.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. False negative.
PS00789. CHORISMATE_SYNTHASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_BIFLO
AccessionPrimary (citable) accession number: Q8G5X3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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