Reviewed,
UniProtKB/Swiss-Prot Q8G5P2 (KPRS_BIFLO)
Last modified
February 9, 2010.
Version 42.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ribose-phosphate pyrophosphokinase Short name=RPPK EC=2.7.6.1 Alternative name(s): Phosphoribosyl pyrophosphate synthetase Short name=P-Rib-PP synthetase Short name=PRPP synthetase | ||||||
| Gene names |
| ||||||
| Organism | Bifidobacterium longum [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 216816 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium |
Protein attributes
| Sequence length | 340 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00583 |
| Cofactor | Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00583 |
| Pathway | Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP MF_00583 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00583. |
| Sequence similarities | Belongs to the ribose-phosphate pyrophosphokinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | nucleoside metabolic process Inferred from electronic annotation. Source: InterPro ribonucleoside monophosphate biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activityInferred from electronic annotation. Source: UniProtKB-KW magnesium ion bindingInferred from electronic annotation. Source: HAMAP ribose phosphate diphosphokinase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 340 | 340 | Ribose-phosphate pyrophosphokinase HAMAP MF_00583 | PRO_0000141111 | |||||
Regions | |||||||||
| Region | 227 – 240 | 14 | Binding of phosphoribosylpyrophosphate Potential | ||||||
Sites | |||||||||
| Metal binding | 138 | 1 | Magnesium Potential | ||||||
| Metal binding | 140 | 1 | Magnesium Potential | ||||||
| Metal binding | 149 | 1 | Magnesium Potential | ||||||
| Metal binding | 153 | 1 | Magnesium Potential | ||||||
Sequences
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References
| [1] | "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract." Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F. Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed: 12381787] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCC 2705. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE014295 Genomic DNA. Translation: AAN24774.1. Different initiation. |
| RefSeq | NP_696138.1. |
3D structure databases | |
| SMR | Q8G5P2. Positions 13-327. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1022464. |
| GenomeReviews | Gene locus BL0963 in contig AE014295_GR. |
| KEGG | blo:BL0963. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG519284. |
| OMA | YKTAGAD. |
Enzyme and pathway databases | |
| BioCyc | BLON206672:BL0963-MONOMER. |
| BRENDA | 2.7.6.1. 39917. |
Family and domain databases | |
| HAMAP | MF_00583_B. RibP_PPkinase_B. [Tree] |
| InterPro | IPR000842. PRib-PP_synthetase_CS. IPR000836. PRibTrfase. IPR005946. PRPP_kinase. [Graphical view] |
| Pfam | PF00156. Pribosyltran. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01251. ribP_PPkin. 1 hit. |
| PROSITE | PS00114. PRPP_SYNTHETASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | KPRS_BIFLO | ||||||||
| Accession | Primary (citable) accession number: Q8G5P2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


