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Q8G5P2 (KPRS_BIFLO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribose-phosphate pyrophosphokinase

Short name=RPPK
EC=2.7.6.1
Alternative name(s):
Phosphoribosyl pyrophosphate synthase
Short name=P-Rib-PP synthase
Short name=PRPP synthase
Gene names
Name:prs
Synonyms:prsA
Ordered Locus Names:BL0963
OrganismBifidobacterium longum (strain NCC 2705)
Taxonomic identifier206672 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00583_B

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00583_B

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP MF_00583_B

Subcellular location

Cytoplasm By similarity HAMAP MF_00583_B.

Sequence similarities

Belongs to the ribose-phosphate pyrophosphokinase family.

Sequence caution

The sequence AAN24774.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340Ribose-phosphate pyrophosphokinase HAMAP MF_00583_B
PRO_0000141111

Regions

Region227 – 24014Binding of phosphoribosylpyrophosphate Potential

Sites

Metal binding1381Magnesium Potential
Metal binding1401Magnesium Potential
Metal binding1491Magnesium Potential
Metal binding1531Magnesium Potential

Sequences

Sequence LengthMass (Da)Tools
Q8G5P2 [UniParc].

Last modified April 13, 2004. Version 2.
Checksum: 93A682F022A8A300

FASTA34036,863
        10         20         30         40         50         60 
MVSAILEGKP DKNLILVTGR IHPKLAEDVA EQLGIDVLET TAYDFANGEM YVRYTESVRG 

        70         80         90        100        110        120 
ADVFVLQSHY KPINKAIMEQ LIMIDALKRA SARSITAVCP LLGYSRQDKK HRGREPISCR 

       130        140        150        160        170        180 
LVFDLLKTAG ADRIMSVDLH AAQSQGFFDG PVDHLVAMPV LVDYIRDRFQ GHLDNVAVVS 

       190        200        210        220        230        240 
PDAGRIRVAE QWAQRLGGGP LAFVHKTRDI TRPNQAVANR VVGDVAGKDC VLVDDLIDTA 

       250        260        270        280        290        300 
GTIAGACHVL QDAGAKSVTV VATHGVLSGP AVERLKNCGA REVVLTDTVP IPEEKRWDGL 

       310        320        330        340 
TVLSIAPLLA SAIRAVFEDG SVAELFDTYP EHHGQGFLFA 

« Hide

References

[1]"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed: 12381787] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCC 2705.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014295 Genomic DNA. Translation: AAN24774.1. Different initiation.
RefSeqNP_696138.1. NC_004307.2.

3D structure databases

ProteinModelPortalQ8G5P2.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1022464.
GenomeReviewsGene locus BL0963 in contig AE014295_GR.
KEGGblo:BL0963.
PATRIC21118393. VBIBifLon107831_0667.

Phylogenomic databases

HOGENOMHBG519284.
OMATDTIPLT.
PhylomeDBQ8G5P2.
ProtClustDBPRK03092.

Enzyme and pathway databases

BioCycBLON206672:BL0963-MONOMER.

Family and domain databases

HAMAPMF_00583_B. RibP_PPkinase_B.
[Tree]
InterProIPR000842. PRib_PP_synth_CS.
IPR000836. PRibTrfase.
IPR005946. Rib-P_diPkinase.
[Graphical view]
KOK00948.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01251. RibP_PPkin. 1 hit.
PROSITEPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPRS_BIFLO
AccessionPrimary (citable) accession number: Q8G5P2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: January 25, 2012
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families