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Protein

NAD kinase

Gene

nadK

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei66Proton acceptorUniRule annotation1
Binding sitei71NADUniRule annotation1
Binding sitei152NADUniRule annotation1
Binding sitei171NADUniRule annotation1
Binding sitei206NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi66 – 67NADUniRule annotation2
Nucleotide bindingi141 – 142NADUniRule annotation2
Nucleotide bindingi182 – 187NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLON206672:G1FZZ-718-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:BL1044
OrganismiBifidobacterium longum (strain NCC 2705)
Taxonomic identifieri206672 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
Proteomesi
  • UP000000439 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001206011 – 342NAD kinaseAdd BLAST342

Proteomic databases

PRIDEiQ8G5G8

Interactioni

Protein-protein interaction databases

STRINGi206672.BL1044

Structurei

3D structure databases

ProteinModelPortaliQ8G5G8
SMRiQ8G5G8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227223
KOiK00858
OMAiVNLGHVG
PhylomeDBiQ8G5G8

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q8G5G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRNAVVVT HTRLRQTGTV VAEAVSQLRV AGFEVAIIDN TEAPDFGVQP
60 70 80 90 100
PCVSDDTEIV VVLGGDGTIL RAAELVHCTQ VPILGVNMGH VGFLAEFESF
110 120 130 140 150
QIDEAIRRVS THDYSIDERM IAHVDVWLPG ATKPIEDWAL NDITLERADR
160 170 180 190 200
GKMVELSIRV DDVEMNSFGA DGVIVSTPTG STAYAFSAGG PVMWPNVKAL
210 220 230 240 250
QLIPLAAHAL FARPLIIGSG STFTIDILDD SMSEGWICCD GRRQRALPQG
260 270 280 290 300
TRVMVRESRD TLRLARLSGV PFTNRLVSKF DLPVVGWREH ARNEASSQSL
310 320 330 340
HHGHTFPAAA YAAGVAVAVA GDAGVAGTDP DKPGERDGKA GA
Length:342
Mass (Da):36,613
Last modified:March 1, 2003 - v1
Checksum:i3C215EC0045DB211
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014295 Genomic DNA Translation: AAN24850.1
RefSeqiNP_696214.1, NC_004307.2
WP_011068269.1, NC_004307.2

Genome annotation databases

EnsemblBacteriaiAAN24850; AAN24850; BL1044
GeneIDi1022572
KEGGiblo:BL1044
PATRICifig|206672.9.peg.748

Similar proteinsi

Entry informationi

Entry nameiNADK_BIFLO
AccessioniPrimary (citable) accession number: Q8G5G8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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