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Q8G5F3 (ARLY_BIFLO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:BL1057
OrganismBifidobacterium longum (strain NCC 2705)
Taxonomic identifier206672 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Argininosuccinate lyase HAMAP MF_00006
PRO_0000137741

Sequences

Sequence LengthMass (Da)Tools
Q8G5F3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 947BC541D5A7E78A

FASTA49053,392
        10         20         30         40         50         60 
MTENNEHLAL WGGRFTSGPS PELARLSKST QFDWRLADDD IAGSRAHARA LGRAGLLTAD 

        70         80         90        100        110        120 
ELQRMEDALD TLQRHVDDGS FAPIEDDEDE ATALERGLID IAGDELGGKL RAGRSRNDQI 

       130        140        150        160        170        180 
ACLIRMWLRR HSRVIAGLLL DLVNALIEQS EKAGRTVMPG RTHMQHAQPV LLAHQLMAHA 

       190        200        210        220        230        240 
WPLIRDVQRL IDWDKRINAS PYGSGALAGN TLGLDPEAVA RELGFSRVTD NSIDGTAARD 

       250        260        270        280        290        300 
LVAEFAFVAA MTGVDISRLS EEIIIWNTQE FAFVKLDDGY STGSSIMPQK KNPDIAELAR 

       310        320        330        340        350        360 
GKSGRLIGDL TGLLATLKGL PTAYARDLQE DKEAVFDQVD TLEVLLPAFT GMVRTMHFDG 

       370        380        390        400        410        420 
DRLEEEAPTG FALATDIAEW LVKNGVPFRH AHELSGACVK LAEGRGQELW DLTDNDFIET 

       430        440        450        460        470        480 
FAAFLPADKA PGVREVLSSH GSVDSRNGKG GTAYGRVREQ IADAKAEVEE LKLFPASTSD 

       490 
GSAYKAPGTF

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References

[1]"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed: 12381787] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCC 2705.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014295 Genomic DNA. Translation: AAN24865.1.
RefSeqNP_696229.1. NC_004307.2.

3D structure databases

ProteinModelPortalQ8G5F3.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1022589.
GenomeReviewsGene locus BL1057 in contig AE014295_GR.
KEGGblo:BL1057.
PATRIC21118597. VBIBifLon107831_0763.

Phylogenomic databases

HOGENOMHBG539632.
OMAMPGRTHL.
PhylomeDBQ8G5F3.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycBLON206672:BL1057-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_BIFLO
AccessionPrimary (citable) accession number: Q8G5F3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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