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Q8G595

- PUR5_BIFLO

UniProt

Q8G595 - PUR5_BIFLO

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBLON206672:GI1E-790-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:BL1122
    OrganismiBifidobacterium longum (strain NCC 2705)
    Taxonomic identifieri206672 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000000439: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 345345Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000148198Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi206672.BL1122.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G595.
    SMRiQ8G595. Positions 13-336.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiTKVMLAQ.
    OrthoDBiEOG61CM1V.
    PhylomeDBiQ8G595.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8G595-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKAYENAGV SVEAGYEVVK RIKSHVARTN RPGVVGGIGG FGGLFDLASL    50
    GYKEPVLISG TDGVGTKLMV AKLANKHDTI GIDCVAMCVN DIAAQGAEPL 100
    FFLDYIACGK NDPALLEQVV AGVADGCVQA GSALVGGETA EMPGMYDEDE 150
    YDLAGFSVGV AEKSAIVDGS TIAEGDVLIG LPSTGVHSNG FSLVRKALFE 200
    QAGYTVDTEL DELGGEKLGD VLLTPTKIYV KALSPLFKAG VVKGVAHITG 250
    GGFIENIPRM IPDGLAAEIE LGTWPVLPIF DVLEKAGNID HKEMYNIFNM 300
    GIGMVLAIDP ARKDEALKLL ADNNEPAYVL GSITADTTGT QIVLK 345
    Length:345
    Mass (Da):36,002
    Last modified:March 1, 2003 - v1
    Checksum:i4A48C60D24891797
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014295 Genomic DNA. Translation: AAN24929.1.
    RefSeqiNP_696293.1. NC_004307.2.

    Genome annotation databases

    EnsemblBacteriaiAAN24929; AAN24929; BL1122.
    GeneIDi1022669.
    KEGGiblo:BL1122.
    PATRICi21118737. VBIBifLon107831_0832.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014295 Genomic DNA. Translation: AAN24929.1 .
    RefSeqi NP_696293.1. NC_004307.2.

    3D structure databases

    ProteinModelPortali Q8G595.
    SMRi Q8G595. Positions 13-336.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 206672.BL1122.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN24929 ; AAN24929 ; BL1122 .
    GeneIDi 1022669.
    KEGGi blo:BL1122.
    PATRICi 21118737. VBIBifLon107831_0832.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi TKVMLAQ.
    OrthoDBi EOG61CM1V.
    PhylomeDBi Q8G595.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci BLON206672:GI1E-790-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
      Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
      Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCC 2705.

    Entry informationi

    Entry nameiPUR5_BIFLO
    AccessioniPrimary (citable) accession number: Q8G595
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3