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Reviewed, UniProtKB/Swiss-Prot Q8G568 (LUXS_BIFLO)

Last modified January 19, 2010. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    S-ribosylhomocysteine lyase
    EC=4.4.1.21
Alternative name(s):
    Autoinducer-2 production protein luxS
    AI-2 synthesis protein
Gene names
Name: luxS
Ordered Locus Names: BL1152
OrganismBifidobacterium longum [Complete proteome] [HAMAP]
Taxonomic identifier216816 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium

Protein attributes

Sequence length164 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity. HAMAP MF_00091

Catalytic activity

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione. HAMAP MF_00091

Cofactor

Binds 1 iron ion per subunit By similarity. HAMAP MF_00091

Subunit structure

Homodimer By similarity. HAMAP MF_00091

Sequence similarities

Belongs to the luxS family.

Ontologies

Keywords
   Biological processAutoinducer synthesis
Quorum sensing
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processquorum sensing

Inferred from electronic annotation. Source: HAMAP

   Molecular functionS-ribosylhomocysteine lyase activity

Inferred from electronic annotation. Source: HAMAP

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 164164S-ribosylhomocysteine lyase HAMAP MF_00091
PRO_0000297985

Sites

Metal binding611Iron By similarity
Metal binding651Iron By similarity
Metal binding1311Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8G568-1 [UniParc].

Last modified August 21, 2007. Version 2.
Checksum: CDC4BD9D1BAA57E5

FASTA16418,451
        10         20         30         40         50         60 
MAEETAEKPV VESFQLDHTK VKAPYVRYID TETGPHGDVI SNYDLRLTQP NEQAIPTGGL 

        70         80         90        100        110        120 
HTIEHTIAVL LRERIPGYID CSPFGCRTGF HLLTWGTHST EDVAKALKES LEFIAYKATW 

       130        140        150        160 
DDVPATTEKS CGNYRDHSLF TAKEWAKLIL EEGISSDPFE RKVV 

« Hide

References

[1]"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed: 12381787] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCC 2705.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014295 Genomic DNA. Translation: AAN24957.1. Different initiation.
RefSeqNP_696321.2.

3D structure databases

HSSPHSSP built from PDB template 1VH2 based on UniProtKB Q9RRU8.
SMRQ8G568. Positions 11-157.
ModBaseSearch...

Genome annotation databases

GeneID1022825.
GenomeReviewsGene locus BL1152 in contig AE014295_GR.
KEGGblo:BL1152.
NMPDRfig|206672.1.peg.1088.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG347473.
OMAVRIAKTM.

Enzyme and pathway databases

BioCycBLON206672:BL1152-MONOMER.
BRENDA4.4.1.21. 39917.

Family and domain databases

HAMAPMF_00091. LuxS.
[Tree]
InterProIPR011249. Metalloenz_metal-bd.
IPR003815. S-ribosylhomocysteinase.
[Graphical view]
Gene3DG3DSA:3.30.1360.80. S-ribosylhomocysteinase. 1 hit.
PfamPF02664. LuxS. 1 hit.
[Graphical view]
PIRSFPIRSF006160. AI2. 1 hit.
PRINTSPR01487. LUXSPROTEIN.
ProDomPD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameLUXS_BIFLO
AccessionPrimary (citable) accession number: Q8G568
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: January 19, 2010
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents