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Q8G534

- DEF1_BIFLO

UniProt

Q8G534 - DEF1_BIFLO

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Protein
Peptide deformylase 1
Gene
def1, BL1186
Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi129 – 1291Iron By similarity
Metal bindingi171 – 1711Iron By similarity
Active sitei172 – 1721 By similarity
Metal bindingi175 – 1751Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciBLON206672:GI1E-853-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 1 (EC:3.5.1.88)
Short name:
PDF 1
Alternative name(s):
Polypeptide deformylase 1
Gene namesi
Name:def1
Ordered Locus Names:BL1186
OrganismiBifidobacterium longum (strain NCC 2705)
Taxonomic identifieri206672 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000000439: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Peptide deformylase 1UniRule annotation
PRO_0000082742Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi206672.BL1186.

Structurei

3D structure databases

ProteinModelPortaliQ8G534.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243508.
KOiK01462.
OMAiGWQARIV.
OrthoDBiEOG664CMF.
PhylomeDBiQ8G534.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8G534-1 [UniParc]FASTAAdd to Basket

« Hide

MFGKNAKVDL ELNRDVEQLI KTGGKEKLLP IVQAGEPVLR QRTVAYNGQL    50
SKRTLAKLID TMHTTMLEAP GVGLAATQIG LGLALAVVED HVRDDEDDPR 100
EIAEFPFHVI INPSYKPTSD KTASFYEGCL SFDGYQAVRK RWLDITAEWD 150
DEDGKHHSEP LHGWPARIFQ HETDHLSGEL YIDRAEIRSL TTNENLEDYW 200
CEDPVPTEAA EELGFAL 217
Length:217
Mass (Da):24,443
Last modified:March 1, 2003 - v1
Checksum:i52F5B469B6F47163
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014295 Genomic DNA. Translation: AAN24991.1.
RefSeqiNP_696355.1. NC_004307.2.

Genome annotation databases

EnsemblBacteriaiAAN24991; AAN24991; BL1186.
GeneIDi1022716.
KEGGiblo:BL1186.
PATRICi21118873. VBIBifLon107831_0899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014295 Genomic DNA. Translation: AAN24991.1 .
RefSeqi NP_696355.1. NC_004307.2.

3D structure databases

ProteinModelPortali Q8G534.
ModBasei Search...

Protein-protein interaction databases

STRINGi 206672.BL1186.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN24991 ; AAN24991 ; BL1186 .
GeneIDi 1022716.
KEGGi blo:BL1186.
PATRICi 21118873. VBIBifLon107831_0899.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243508.
KOi K01462.
OMAi GWQARIV.
OrthoDBi EOG664CMF.
PhylomeDBi Q8G534.

Enzyme and pathway databases

BioCyci BLON206672:GI1E-853-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
    Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
    Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCC 2705.

Entry informationi

Entry nameiDEF1_BIFLO
AccessioniPrimary (citable) accession number: Q8G534
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi