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Reviewed, UniProtKB/Swiss-Prot Q8G4X3 (GLUQ_BIFLO)

Last modified January 19, 2010. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glutamyl-Q tRNA(Asp) synthetase
      Short name=Glu-Q-RSs
    EC=6.1.1.-
Gene names
Name: gluQ
Ordered Locus Names: BL1251
OrganismBifidobacterium longum [Complete proteome] [HAMAP]
Taxonomic identifier216816 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

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Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon By similarity. HAMAP MF_01428

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_01428

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Glutamyl-Q tRNA(Asp) synthetase HAMAP MF_01428
PRO_0000208287

Regions

Region14 – 185Glutamate binding By similarity
Motif17 – 2711"HIGH" region HAMAP MF_01428
Motif300 – 3045"KMSKS" region HAMAP MF_01428

Sites

Metal binding1061Zinc By similarity
Metal binding1081Zinc By similarity
Metal binding1281Zinc By similarity
Metal binding1321Zinc By similarity
Binding site501Glutamate By similarity
Binding site2291Glutamate By similarity
Binding site2471Glutamate By similarity
Binding site3031ATP By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q8G4X3-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: DEAC7D620B757C8B

FASTA37942,168
        10         20         30         40         50         60 
MVLNFIRGGP VTGRFAPTPS GRMHIGNVYA MLGAWLSARS RGDRMLMRIE DVDKPRVVAG 

        70         80         90        100        110        120 
ADQLMMDDLH WLGLDWDGEP MFQSQRTERY EYALECLRSQ GVLYPCFCSR ADIRAASAPN 

       130        140        150        160        170        180 
EGDGFMVYPG TCRRLLHDHP DEVRARLVRG DQHSIRIAMP ESAAGEKQRT VPDDSAALSG 

       190        200        210        220        230        240 
AVPPEQQGDA GIVDGVACFN DRVYSPQHYD LAREVGDSVI RRADGLFGYQ LVVVVDDLDM 

       250        260        270        280        290        300 
GVDDIVRGRD LLRSTALQMW IRQCLLAGGF EPECGNTEKP LAEHPEYAHL PLIDNAAGRR 

       310        320        330        340        350        360 
LAKRERSLDM GALRARNVTP EQIIGYCAWL LRLQPTPIPC KPADLLADFS WEPLRANHLD 

       370 
RALKPDDPTT PQWLAEALG

« Hide

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References

[1]"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed: 12381787] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCC 2705.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014295 Genomic DNA. Translation: AAN25052.1.
RefSeqNP_696416.1.

3D structure databases

SMRQ8G4X3. Positions 10-324, 11-353.
ModBaseSearch...

Genome annotation databases

GeneID1022750.
GenomeReviewsGene locus BL1251 in contig AE014295_GR.
KEGGblo:BL1251.
NMPDRfig|206672.1.peg.1183.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG628189.
OMADAPSSYH.
PhylomeDBQ8G4X3.

Enzyme and pathway databases

BioCycBLON206672:BL1251-MONOMER.

Family and domain databases

HAMAPMF_01428. Glu_Q_tRNA_synth. Divergent sequence.
[Tree]
InterProIPR000924. Glu/Gln-tRNA-synth_Ic.
IPR020058. Glu/Gln-tRNA-synth_Ic_cat-dom.
IPR020060. Glu/Gln-tRNA-synth_Ic_N.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHERPTHR10119. Glu_tRNA-synt_1c. 1 hit.
PfamPF00749. tRNA-synt_1c. 2 hits.
[Graphical view]
PRINTSPR00987. TRNASYNTHGLU.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGLUQ_BIFLO
AccessionPrimary (citable) accession number: Q8G4X3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: March 1, 2003
Last modified: January 19, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents