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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei139 – 1391NADUniRule annotation
Binding sitei204 – 2041NADUniRule annotation
Binding sitei236 – 2361NADUniRule annotation
Binding sitei259 – 2591SubstrateUniRule annotation
Metal bindingi281 – 2811ZincUniRule annotation
Binding sitei281 – 2811SubstrateUniRule annotation
Metal bindingi284 – 2841ZincUniRule annotation
Binding sitei284 – 2841SubstrateUniRule annotation
Active sitei350 – 3501Proton acceptorUniRule annotation
Active sitei351 – 3511Proton acceptorUniRule annotation
Binding sitei351 – 3511SubstrateUniRule annotation
Metal bindingi384 – 3841ZincUniRule annotation
Binding sitei384 – 3841SubstrateUniRule annotation
Binding sitei438 – 4381SubstrateUniRule annotation
Metal bindingi443 – 4431ZincUniRule annotation
Binding sitei443 – 4431SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBLON206672:GI1E-136-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:BL1295
OrganismiBifidobacterium longum (strain NCC 2705)
Taxonomic identifieri206672 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000000439: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Histidinol dehydrogenasePRO_0000135733Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi206672.BL1295.

Structurei

3D structure databases

ProteinModelPortaliQ8G4S9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ8G4S9.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G4S9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRWGVMSEN IMRIIDLRGQ NLSRAELLAA MPRAAMGTSE ATDLVRPILD
60 70 80 90 100
DVKERGAAAL RDFEEKFDHV RPKNLRVPVE AIKDALTTLD PEVRAAIEES
110 120 130 140 150
VRRARAVAAN QVPKDFYTDL AEGARVAERW IPIQRVGLYV PGGKAVYPSS
160 170 180 190 200
VIMNAVPAQA AGVESLAIAT PPARDNEEGL PNKTILATCA ILGVDEVYAV
210 220 230 240 250
GGAQAIAMFA YGAKGSEPQD GDILCDPVDK ITGPGNIFVA TAKSLVSAFV
260 270 280 290 300
GIDAVAGPTE IGIIADETAN PSLLAADLIG QAEHDELAGS VLFTDSTEIA
310 320 330 340 350
DKVQESLKYR VPRTEHAERV HTSLSGTQSA IVLTDGLDQS IDAANAYAAE
360 370 380 390 400
HLEIQTKDAD AVVKRIKNAG AIFRGPYSPV PLGDYMSGSN HVLPTGGTAR
410 420 430 440 450
FAAGLGVHTF MKPVEVIEYD EEGLKALAAR INAFAVSEDL PAHGECVLSR
460 470
FVKDPYDKAT LREQEKEAGL R
Length:471
Mass (Da):50,257
Last modified:March 1, 2003 - v1
Checksum:i36D6D724978BDC88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014295 Genomic DNA. Translation: AAN25096.1.
RefSeqiNP_696460.1. NC_004307.2.

Genome annotation databases

EnsemblBacteriaiAAN25096; AAN25096; BL1295.
GeneIDi1022774.
KEGGiblo:BL1295.
PATRICi21117323. VBIBifLon107831_0144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014295 Genomic DNA. Translation: AAN25096.1.
RefSeqiNP_696460.1. NC_004307.2.

3D structure databases

ProteinModelPortaliQ8G4S9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi206672.BL1295.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN25096; AAN25096; BL1295.
GeneIDi1022774.
KEGGiblo:BL1295.
PATRICi21117323. VBIBifLon107831_0144.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ8G4S9.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.
BioCyciBLON206672:GI1E-136-MONOMER.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
    Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
    Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCC 2705.

Entry informationi

Entry nameiHISX_BIFLO
AccessioniPrimary (citable) accession number: Q8G4S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.