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Q8G4S9

- HISX_BIFLO

UniProt

Q8G4S9 - HISX_BIFLO

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei139 – 1391NADUniRule annotation
    Binding sitei204 – 2041NADUniRule annotation
    Binding sitei236 – 2361NADUniRule annotation
    Binding sitei259 – 2591SubstrateUniRule annotation
    Metal bindingi281 – 2811ZincUniRule annotation
    Binding sitei281 – 2811SubstrateUniRule annotation
    Metal bindingi284 – 2841ZincUniRule annotation
    Binding sitei284 – 2841SubstrateUniRule annotation
    Active sitei350 – 3501Proton acceptorUniRule annotation
    Active sitei351 – 3511Proton acceptorUniRule annotation
    Binding sitei351 – 3511SubstrateUniRule annotation
    Metal bindingi384 – 3841ZincUniRule annotation
    Binding sitei384 – 3841SubstrateUniRule annotation
    Binding sitei438 – 4381SubstrateUniRule annotation
    Metal bindingi443 – 4431ZincUniRule annotation
    Binding sitei443 – 4431SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciBLON206672:GI1E-136-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:BL1295
    OrganismiBifidobacterium longum (strain NCC 2705)
    Taxonomic identifieri206672 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000000439: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 471471Histidinol dehydrogenasePRO_0000135733Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi206672.BL1295.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G4S9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiQKSLHAV.
    OrthoDBiEOG6CVVCR.
    PhylomeDBiQ8G4S9.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8G4S9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRWGVMSEN IMRIIDLRGQ NLSRAELLAA MPRAAMGTSE ATDLVRPILD    50
    DVKERGAAAL RDFEEKFDHV RPKNLRVPVE AIKDALTTLD PEVRAAIEES 100
    VRRARAVAAN QVPKDFYTDL AEGARVAERW IPIQRVGLYV PGGKAVYPSS 150
    VIMNAVPAQA AGVESLAIAT PPARDNEEGL PNKTILATCA ILGVDEVYAV 200
    GGAQAIAMFA YGAKGSEPQD GDILCDPVDK ITGPGNIFVA TAKSLVSAFV 250
    GIDAVAGPTE IGIIADETAN PSLLAADLIG QAEHDELAGS VLFTDSTEIA 300
    DKVQESLKYR VPRTEHAERV HTSLSGTQSA IVLTDGLDQS IDAANAYAAE 350
    HLEIQTKDAD AVVKRIKNAG AIFRGPYSPV PLGDYMSGSN HVLPTGGTAR 400
    FAAGLGVHTF MKPVEVIEYD EEGLKALAAR INAFAVSEDL PAHGECVLSR 450
    FVKDPYDKAT LREQEKEAGL R 471
    Length:471
    Mass (Da):50,257
    Last modified:March 1, 2003 - v1
    Checksum:i36D6D724978BDC88
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014295 Genomic DNA. Translation: AAN25096.1.
    RefSeqiNP_696460.1. NC_004307.2.

    Genome annotation databases

    EnsemblBacteriaiAAN25096; AAN25096; BL1295.
    GeneIDi1022774.
    KEGGiblo:BL1295.
    PATRICi21117323. VBIBifLon107831_0144.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014295 Genomic DNA. Translation: AAN25096.1 .
    RefSeqi NP_696460.1. NC_004307.2.

    3D structure databases

    ProteinModelPortali Q8G4S9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 206672.BL1295.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN25096 ; AAN25096 ; BL1295 .
    GeneIDi 1022774.
    KEGGi blo:BL1295.
    PATRICi 21117323. VBIBifLon107831_0144.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi QKSLHAV.
    OrthoDBi EOG6CVVCR.
    PhylomeDBi Q8G4S9.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci BLON206672:GI1E-136-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
      Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
      Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCC 2705.

    Entry informationi

    Entry nameiHISX_BIFLO
    AccessioniPrimary (citable) accession number: Q8G4S9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3