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Q8G4S9

- HISX_BIFLO

UniProt

Q8G4S9 - HISX_BIFLO

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Protein
Histidinol dehydrogenase
Gene
hisD, BL1295
Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei139 – 1391NAD By similarity
Binding sitei204 – 2041NAD By similarity
Binding sitei236 – 2361NAD By similarity
Binding sitei259 – 2591Substrate By similarity
Metal bindingi281 – 2811Zinc By similarity
Binding sitei281 – 2811Substrate By similarity
Metal bindingi284 – 2841Zinc By similarity
Binding sitei284 – 2841Substrate By similarity
Active sitei350 – 3501Proton acceptor By similarity
Active sitei351 – 3511Proton acceptor By similarity
Binding sitei351 – 3511Substrate By similarity
Metal bindingi384 – 3841Zinc By similarity
Binding sitei384 – 3841Substrate By similarity
Binding sitei438 – 4381Substrate By similarity
Metal bindingi443 – 4431Zinc By similarity
Binding sitei443 – 4431Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBLON206672:GI1E-136-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:BL1295
OrganismiBifidobacterium longum (strain NCC 2705)
Taxonomic identifieri206672 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000000439: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Histidinol dehydrogenaseUniRule annotation
PRO_0000135733Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi206672.BL1295.

Structurei

3D structure databases

ProteinModelPortaliQ8G4S9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiQKSLHAV.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ8G4S9.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G4S9-1 [UniParc]FASTAAdd to Basket

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MLRWGVMSEN IMRIIDLRGQ NLSRAELLAA MPRAAMGTSE ATDLVRPILD    50
DVKERGAAAL RDFEEKFDHV RPKNLRVPVE AIKDALTTLD PEVRAAIEES 100
VRRARAVAAN QVPKDFYTDL AEGARVAERW IPIQRVGLYV PGGKAVYPSS 150
VIMNAVPAQA AGVESLAIAT PPARDNEEGL PNKTILATCA ILGVDEVYAV 200
GGAQAIAMFA YGAKGSEPQD GDILCDPVDK ITGPGNIFVA TAKSLVSAFV 250
GIDAVAGPTE IGIIADETAN PSLLAADLIG QAEHDELAGS VLFTDSTEIA 300
DKVQESLKYR VPRTEHAERV HTSLSGTQSA IVLTDGLDQS IDAANAYAAE 350
HLEIQTKDAD AVVKRIKNAG AIFRGPYSPV PLGDYMSGSN HVLPTGGTAR 400
FAAGLGVHTF MKPVEVIEYD EEGLKALAAR INAFAVSEDL PAHGECVLSR 450
FVKDPYDKAT LREQEKEAGL R 471
Length:471
Mass (Da):50,257
Last modified:March 1, 2003 - v1
Checksum:i36D6D724978BDC88
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014295 Genomic DNA. Translation: AAN25096.1.
RefSeqiNP_696460.1. NC_004307.2.

Genome annotation databases

EnsemblBacteriaiAAN25096; AAN25096; BL1295.
GeneIDi1022774.
KEGGiblo:BL1295.
PATRICi21117323. VBIBifLon107831_0144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014295 Genomic DNA. Translation: AAN25096.1 .
RefSeqi NP_696460.1. NC_004307.2.

3D structure databases

ProteinModelPortali Q8G4S9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 206672.BL1295.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN25096 ; AAN25096 ; BL1295 .
GeneIDi 1022774.
KEGGi blo:BL1295.
PATRICi 21117323. VBIBifLon107831_0144.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi QKSLHAV.
OrthoDBi EOG6CVVCR.
PhylomeDBi Q8G4S9.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci BLON206672:GI1E-136-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
    Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
    Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCC 2705.

Entry informationi

Entry nameiHISX_BIFLO
AccessioniPrimary (citable) accession number: Q8G4S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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