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Q8G4S9 (HISX_BIFLO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase
Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:BL1295
OrganismBifidobacterium longum (strain NCC 2705)
Taxonomic identifier206672 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 471471Histidinol dehydrogenase HAMAP MF_01024
PRO_0000135733

Sites

Active site3501Proton acceptor By similarity
Active site3511Proton acceptor By similarity
Metal binding2811Zinc By similarity
Metal binding2841Zinc By similarity
Metal binding3841Zinc By similarity
Metal binding4431Zinc By similarity
Binding site1391NAD By similarity
Binding site2041NAD By similarity
Binding site2361NAD By similarity
Binding site2591Substrate By similarity
Binding site2811Substrate By similarity
Binding site2841Substrate By similarity
Binding site3511Substrate By similarity
Binding site3841Substrate By similarity
Binding site4381Substrate By similarity
Binding site4431Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8G4S9 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 36D6D724978BDC88

FASTA47150,257
        10         20         30         40         50         60 
MLRWGVMSEN IMRIIDLRGQ NLSRAELLAA MPRAAMGTSE ATDLVRPILD DVKERGAAAL 

        70         80         90        100        110        120 
RDFEEKFDHV RPKNLRVPVE AIKDALTTLD PEVRAAIEES VRRARAVAAN QVPKDFYTDL 

       130        140        150        160        170        180 
AEGARVAERW IPIQRVGLYV PGGKAVYPSS VIMNAVPAQA AGVESLAIAT PPARDNEEGL 

       190        200        210        220        230        240 
PNKTILATCA ILGVDEVYAV GGAQAIAMFA YGAKGSEPQD GDILCDPVDK ITGPGNIFVA 

       250        260        270        280        290        300 
TAKSLVSAFV GIDAVAGPTE IGIIADETAN PSLLAADLIG QAEHDELAGS VLFTDSTEIA 

       310        320        330        340        350        360 
DKVQESLKYR VPRTEHAERV HTSLSGTQSA IVLTDGLDQS IDAANAYAAE HLEIQTKDAD 

       370        380        390        400        410        420 
AVVKRIKNAG AIFRGPYSPV PLGDYMSGSN HVLPTGGTAR FAAGLGVHTF MKPVEVIEYD 

       430        440        450        460        470 
EEGLKALAAR INAFAVSEDL PAHGECVLSR FVKDPYDKAT LREQEKEAGL R

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References

[1]"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed: 12381787] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCC 2705.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014295 Genomic DNA. Translation: AAN25096.1.
RefSeqNP_696460.1. NC_004307.2.

3D structure databases

ProteinModelPortalQ8G4S9.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1022774.
GenomeReviewsGene locus BL1295 in contig AE014295_GR.
KEGGblo:BL1295.
NMPDRfig|206672.1.peg.1227.
PATRIC21117323. VBIBifLon107831_0144.

Phylogenomic databases

HOGENOMHBG329596.
OMANRYVTEA.
PhylomeDBQ8G4S9.
ProtClustDBPRK00877.

Enzyme and pathway databases

BioCycBLON206672:BL1295-MONOMER.

Family and domain databases

HAMAPMF_01024. HisD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
KOK00013.
PANTHERPTHR21256:SF2. Hstdl_DH_prok. 1 hit.
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00069. HisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_BIFLO
AccessionPrimary (citable) accession number: Q8G4S9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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