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Q8G4R0 (RSMH_BIFLO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribosomal RNA small subunit methyltransferase H
EC=2.1.1.199
Alternative name(s):
16S rRNA m(4)C1402 methyltransferase
rRNA (cytosine-N(4)-)-methyltransferase RsmH
Gene names
Name:rsmH
Synonyms:mraW
Ordered Locus Names:BL1316
OrganismBifidobacterium longum (strain NCC 2705)
Taxonomic identifier206672 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA By similarity. HAMAP MF_01007

Catalytic activity

S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + N(4)-methylcytosine(1402) in 16S rRNA. HAMAP MF_01007

Subcellular location

Cytoplasm By similarity HAMAP MF_01007.

Sequence similarities

Belongs to the methyltransferase superfamily. RsmH family.

Ontologies

Keywords
   Biological processrRNA processing
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processrRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmethyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Ribosomal RNA small subunit methyltransferase H HAMAP MF_01007
PRO_0000108583

Regions

Region39 – 413S-adenosyl-L-methionine binding By similarity

Sites

Binding site581S-adenosyl-L-methionine By similarity
Binding site871S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding site1081S-adenosyl-L-methionine By similarity
Binding site1151S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8G4R0 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: EF9364CD19F03CBD

FASTA35939,659
        10         20         30         40         50         60 
MVDVANIHLP VLLDDCVNLM APALEHENAI AVDCTLGLAG HSIAFLKAAP QARLIGIDRD 

        70         80         90        100        110        120 
SEALGLATER MEREGLADRF IPVHAAFDQL DQVLADQDIE RVDAVFMDLG LSSLQIDETD 

       130        140        150        160        170        180 
RGFSYSHDAP LDMRMDVSQP LTAERILATY DAAELVRIFK EYGEERFSRQ IARAIVARRD 

       190        200        210        220        230        240 
KEPFTTTAQL NRLVDEVVPQ AHRPAGNPAK RVFQALRIEV NGELDKLAST LPQAANRLHV 

       250        260        270        280        290        300 
GGRLVVESYH SLEDKTVKSF MAQGLRVDVP AGLPVIPPDA QPFFTDLTRG AIKADEHEIA 

       310        320        330        340        350 
ANPRSASVRL RAVEVSREIP SRWRKRFTQT AQGLNDVKIQ GSASPGRAKN TARIRTRRG

« Hide

References

[1]"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed: 12381787] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCC 2705.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014295 Genomic DNA. Translation: AAN25116.1.
RefSeqNP_696480.1. NC_004307.2.

3D structure databases

ProteinModelPortalQ8G4R0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1022796.
GenomeReviewsGene locus BL1316 in contig AE014295_GR.
KEGGblo:BL1316.
PATRIC21117367. VBIBifLon107831_0166.

Phylogenomic databases

HOGENOMHBG302779.
OMANPATRAF.
PhylomeDBQ8G4R0.
ProtClustDBPRK00050.

Enzyme and pathway databases

BioCycBLON206672:BL1316-MONOMER.

Family and domain databases

HAMAPMF_01007. 16SrRNA_methyltr_H.
[Tree]
InterProIPR002903. SAM-dep_MeTrfase_MraW.
IPR023397. SAM-dep_MeTrfase_MraW_recog.
[Graphical view]
Gene3DG3DSA:1.10.150.170. G3DSA:1.10.150.170. 1 hit.
KOK03438.
PANTHERPTHR11265. Bact_methyltrans. 1 hit.
PfamPF01795. Methyltransf_5. 1 hit.
[Graphical view]
PIRSFPIRSF004486. MraW. 1 hit.
SUPFAMSSF81799. SSF81799. 1 hit.
TIGRFAMsTIGR00006. TIGR00006. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRSMH_BIFLO
AccessionPrimary (citable) accession number: Q8G4R0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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