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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:BL1320
OrganismiBifidobacterium longum (strain NCC 2705)
Taxonomic identifieri206672 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
Proteomesi
  • UP000000439 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalUniRule annotationAdd BLAST21
Transmembranei51 – 71HelicalUniRule annotationAdd BLAST21
Transmembranei80 – 100HelicalUniRule annotationAdd BLAST21
Transmembranei117 – 137HelicalUniRule annotationAdd BLAST21
Transmembranei167 – 187HelicalUniRule annotationAdd BLAST21
Transmembranei193 – 213HelicalUniRule annotationAdd BLAST21
Transmembranei234 – 254HelicalUniRule annotationAdd BLAST21
Transmembranei260 – 282HelicalUniRule annotationAdd BLAST23
Transmembranei287 – 309HelicalUniRule annotationAdd BLAST23
Transmembranei340 – 360HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001087881 – 368Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST368

Interactioni

Protein-protein interaction databases

STRINGi206672.BL1320.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275124.
KOiK01000.
OMAiLMSPLHH.
PhylomeDBiQ8G4Q7.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8G4Q7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIALIIGMLV SLIVTLVGTP LLIRLVHKLH YGQYIRQDGP QSHLVKRGTP
60 70 80 90 100
TLGGVVINFA ILLGWASSAL YRYLRSGDVP SWSAALVLFA MLSMGLLGFI
110 120 130 140 150
DDFAKVRKKQ NEGLSVGGKF IGQFIFATIY AVLALLIPTK SGFPSAQAGI
160 170 180 190 200
SFIEQPFFNF DFAGRAVAII LFVIWVNFLM TAWTNAVNLT DGLDGLAAGS
210 220 230 240 250
SMIAFTGFGI IAFWESYHIK GGSHGGYSYA VSDPLDLTVI AVCAAVACFG
260 270 280 290 300
FLWYNSNPAS IFMGDTGSLA LGGLFAALSI ATHTEFLAVV LGGLYVMEAM
310 320 330 340 350
SDVIQVGYFK MTHKRVFKMA PIHHHFELEG WTETKVVVRF WMIELIFVLL
360
ALTIFYGDWV TRSGLLFS
Length:368
Mass (Da):40,156
Last modified:March 1, 2003 - v1
Checksum:i5AB5D515BA7E1718
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014295 Genomic DNA. Translation: AAN25120.1.
RefSeqiNP_696484.1. NC_004307.2.
WP_007052547.1. NC_004307.2.

Genome annotation databases

EnsemblBacteriaiAAN25120; AAN25120; BL1320.
GeneIDi1022799.
KEGGiblo:BL1320.
PATRICifig|206672.9.peg.171.

Similar proteinsi

Entry informationi

Entry nameiMRAY_BIFLO
AccessioniPrimary (citable) accession number: Q8G4Q7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2003
Last modified: June 7, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families