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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi947 – 9471ZincUniRule annotation
Metal bindingi949 – 9491ZincUniRule annotation
Metal bindingi958 – 9581ZincUniRule annotation
Metal bindingi959 – 9591ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi101 – 1088ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBLON206672:GI1E-260-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:BL1419
OrganismiBifidobacterium longum (strain NCC 2705)
Taxonomic identifieri206672 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
Proteomesi
  • UP000000439 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 964964Protein translocase subunit SecAPRO_0000318326Add
BLAST

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi206672.BL1419.

Structurei

3D structure databases

ProteinModelPortaliQ8G4G5.
SMRiQ8G4G5. Positions 1-831.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.
PhylomeDBiQ8G4G5.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G4G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDIIDKALR MGEGHQLKKL ENVAKAVNAL EDEISALSDE DLKAQTPKFK
60 70 80 90 100
QEIENGKSLD EIMPEAFATV REVSKRTLGQ RHFDVQLMGG AALHWGNIAE
110 120 130 140 150
MKTGEGKTLV ATLPTYLNAL EGRGVHVVTV NDYLASYQSE LMGRIYRFLG
160 170 180 190 200
MNVGCIITEQ KPPERRKQYN ADITYGTNNE FGFDYLRDNM AWEKADLVQR
210 220 230 240 250
GHHYAIVDEV DSILIDEART PLIISGPAEG DVTRWYRQFA KLVLKLTRDE
260 270 280 290 300
DYDVDEKKKV VGILDPGITK VEDFLGIDNL YEPANTALIG YLNNAIKAKE
310 320 330 340 350
LFLRDKDYVV TQGEVLIVDE HTGRILPGRR YNEGLHQAIE AKEGVEVKAE
360 370 380 390 400
NQTFATITLQ NYFRMYDKLA GMTGTAETEA AEFMNTYKLG VLPIKTNKPM
410 420 430 440 450
IRKDQDDLIY RTKKEKLAAI VKDVAKRHAK GQPVLLGTAS VESSEVVSTL
460 470 480 490 500
LDVAKIPHQV LNAKQHEKEA AVVAVAGRKG AVTVATNMAG RGTDIMLGGN
510 520 530 540 550
VEFLADAKLK SEGYSPEDTP EEYEKRWPGT LNEIKAQVKD EHEEVKELGG
560 570 580 590 600
LYVLGTERHE SRRIDNQLRG RSGRQGDPGE SRFYLSLEDD LMRLFNTQLV
610 620 630 640 650
AQVMAKGMEE GQPIEAKSVT KGVRTAQKAV ESRNYEIRKN VLKYDDVMNK
660 670 680 690 700
QRTVIYSERQ AVLKGEDIHK DILRFISDTV ESYIKGANKG SEKPKDWDWE
710 720 730 740 750
GLFKALNTVI PTKVDEDEVR KIVGGLKGAK AVEAVRDLIV EDARQQYGEM
760 770 780 790 800
EETIGETGLR DLERRVVLAV LDRKWREHLY EMDYLKDGIG LRGMGQRDPL
810 820 830 840 850
VEYQREGYQM YNSMIEAIKE ETVQLLFHID IKQVATTDEA VDEVEETAES
860 870 880 890 900
ADTIAVASGP DENGESVVEA AEGEVEEEDE DTDAKQAIAE SAAASGAGES
910 920 930 940 950
TLPVAGPAPI SHAEGKVPVS KRPKSEELKT PWADGRTFPG TGKNAPCPCG
960
SGRKYKMCHG QNEK
Length:964
Mass (Da):107,489
Last modified:March 1, 2003 - v1
Checksum:iCD13E8EDEBB514F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014295 Genomic DNA. Translation: AAN25218.1.
RefSeqiNP_696582.1. NC_004307.2.
WP_011068038.1. NC_004307.2.

Genome annotation databases

EnsemblBacteriaiAAN25218; AAN25218; BL1419.
GeneIDi1021574.
KEGGiblo:BL1419.
PATRICi21117591. VBIBifLon107831_0277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014295 Genomic DNA. Translation: AAN25218.1.
RefSeqiNP_696582.1. NC_004307.2.
WP_011068038.1. NC_004307.2.

3D structure databases

ProteinModelPortaliQ8G4G5.
SMRiQ8G4G5. Positions 1-831.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi206672.BL1419.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN25218; AAN25218; BL1419.
GeneIDi1021574.
KEGGiblo:BL1419.
PATRICi21117591. VBIBifLon107831_0277.

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.
PhylomeDBiQ8G4G5.

Enzyme and pathway databases

BioCyciBLON206672:GI1E-260-MONOMER.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECA_BIFLO
AccessioniPrimary (citable) accession number: Q8G4G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.