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Q8G4G1

- PKNA2_BIFLO

UniProt

Q8G4G1 - PKNA2_BIFLO

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Protein

Probable serine/threonine-protein kinase pknA2

Gene

pknA2

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431ATPPROSITE-ProRule annotation
Active sitei140 – 1401Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 289ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. penicillin binding Source: InterPro
  3. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLON206672:GI1E-264-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase pknA2 (EC:2.7.11.1)
Gene namesi
Name:pknA2
Ordered Locus Names:BL1425
OrganismiBifidobacterium longum (strain NCC 2705)
Taxonomic identifieri206672 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000000439: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 757757Probable serine/threonine-protein kinase pknA2PRO_0000171184Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi206672.BL1425.

Structurei

3D structure databases

ProteinModelPortaliQ8G4G1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 274261Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini466 – 53974PASTA 1PROSITE-ProRule annotationAdd
BLAST
Domaini545 – 61470PASTA 2PROSITE-ProRule annotationAdd
BLAST
Domaini615 – 68167PASTA 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 3 PASTA domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000037187.
KOiK00870.
OMAiRISKRAN.
OrthoDBiEOG6B35XT.
PhylomeDBiQ8G4G1.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR005543. PASTA_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF03793. PASTA. 3 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00740. PASTA. 3 hits.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51178. PASTA. 3 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G4G1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSENEPAQMI EGRYRIVRNI AEGGMATVYE AIDERLGRTV AIKVMHTQLA
60 70 80 90 100
KGPHREQFVE RFRREANSAA SIANPHIVQV YDTGEFNGLD FLVMEYVHGV
110 120 130 140 150
NLRHEMNAQG TFSVRETLRV VAETLDGLAS AHRAGVVHRD IKPENILIND
160 170 180 190 200
RGHVQITDFG LAKAASQATL SSTGMLLGTA AYLAPEMIEN NQATAQGDLY
210 220 230 240 250
SVGIMAWEML TGKVPFDSDN PVTLVFKHVH EDVPSVATVC QGIDPSVAAF
260 270 280 290 300
IAHLTARQVD ARPTDGAAAA EELSQLAAKL PLEAWQYRLH AEPIGGDHTD
310 320 330 340 350
ATAAALVGNI AEQAPLTGVP AGAATFKPSV PAFLADDVAS NTVDTGGAAD
360 370 380 390 400
VNPPAPPVAP TTALDSSTPA DASAPHKTQI MAQSGSETQV LPQAGDAFTR
410 420 430 440 450
ALAFSDEPDV ASNGTGPKKQ RSKKPLIIVL VIVLVLAAIG GTAGWWWFAG
460 470 480 490 500
PGSYWSVPKP DDVTCDANAS TECSLAGADW ATYESTLKAL GIPYKTHKEY
510 520 530 540 550
SDDVAEGKII SSSVNKTKAV VNSRISKRAN QELTVVVSKG VRMTTIPKDI
560 570 580 590 600
LDANSANGKD PLNALKKAGF DNVKHDESKD EYSMDTPQGV ALTISPDPGT
610 620 630 640 650
TAKHNDEVTV TLSKGPMPVT MPNIVGKTQD EMQAALGELK LTANVTEQYD
660 670 680 690 700
DKVEAGQVIS ASQEAGAQLK WGDSVDVVIS KGPEMATIPS GLVGKQESAV
710 720 730 740 750
TKTLEGLGFE VKTDKVLGGL FGTVRTVKSG DTDLSNGGKI RLRDANGNPT

VITLTIV
Length:757
Mass (Da):80,088
Last modified:March 1, 2003 - v1
Checksum:iD7916F1B880268D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014295 Genomic DNA. Translation: AAN25222.1.
RefSeqiNP_696586.1. NC_004307.2.

Genome annotation databases

EnsemblBacteriaiAAN25222; AAN25222; BL1425.
GeneIDi1021578.
KEGGiblo:BL1425.
PATRICi21117603. VBIBifLon107831_0283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014295 Genomic DNA. Translation: AAN25222.1 .
RefSeqi NP_696586.1. NC_004307.2.

3D structure databases

ProteinModelPortali Q8G4G1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 206672.BL1425.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN25222 ; AAN25222 ; BL1425 .
GeneIDi 1021578.
KEGGi blo:BL1425.
PATRICi 21117603. VBIBifLon107831_0283.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000037187.
KOi K00870.
OMAi RISKRAN.
OrthoDBi EOG6B35XT.
PhylomeDBi Q8G4G1.

Enzyme and pathway databases

BioCyci BLON206672:GI1E-264-MONOMER.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR005543. PASTA_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF03793. PASTA. 3 hits.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00740. PASTA. 3 hits.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51178. PASTA. 3 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
    Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
    Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCC 2705.

Entry informationi

Entry nameiPKNA2_BIFLO
AccessioniPrimary (citable) accession number: Q8G4G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3