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Q8G4D8

- SYL_BIFLO

UniProt

Q8G4D8 - SYL_BIFLO

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei763 – 7631ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBLON206672:GI1E-287-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BL1450
    OrganismiBifidobacterium longum (strain NCC 2705)
    Taxonomic identifieri206672 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000000439: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 987987Leucine--tRNA ligasePRO_0000151978Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi206672.BL1450.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G4D8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi69 – 8012"HIGH" regionAdd
    BLAST
    Motifi760 – 7645"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiYARYHRM.
    OrthoDBiEOG63Z74X.
    PhylomeDBiQ8G4D8.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8G4D8-1 [UniParc]FASTAAdd to Basket

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    MSDNEKSTQT EEPNFRYNAA LAQDIENKWQ KIWDEQGTFW AANVNGDLKD    50
    GKGRNAEGRT AYFAMDMFPY PSGKGLHVGH PLGYLASDVV SRYHRMKGEN 100
    VLHAMGYDAF GLPAEQYAVQ TGQHPRVTTE ANIANMSRQL HRMGLSFDNR 150
    RTFATIDPGY VRWTQWIFSR IYDSWYDEDA TNPSGSKGSA RPIAELVAKF 200
    ESGEKAIPGH ESDGKQWSDL TDAEQQDILN DFRLAYISKS PVNWCPGLGT 250
    VLANEEVTAE GKSERGNFPV FQRELRQWSM RITKYGHRLI ADLDGINWPE 300
    KVKLMQRNWI GESHGASVHF IVATADGDKD MEIYTTRPDT LFGTTFAVVS 350
    PEHHLLENVP AEWPADVPED WKGGYANPVE AVKAYRLAAE AKTAKDRVNE 400
    AGEKTGLFTG LYATNPITGA KLPLFTADYV LMDYGTGAIM AVPGGDQRDY 450
    DFAVKFGLPV IYTVTPLPDS GDDLANYEGK APFVSHDGIV INSSVEATEA 500
    KGDALSLNGL RVDDAIAKVN AWLESAGVGK GTVSYRLRDW LFSRQRYWGE 550
    PFPIVYGEDG TPHLLPDSAL PINLPDVPDY EPRTFDPMDA ESNPEAPLSR 600
    NEDWVKVELD LGDGKKTYYR DTNTMPNWAG SCWYYMRYID PTDTKHMVEK 650
    DEFDYWMGPN HNKYSGDEGG VDLYIGGVEH AVLHLLYSRF WHKVLFDLGY 700
    VDSAEPFHKL FNQGMIQAYA YTDDRGQYVP ADEVVEGPAD ASGEPTFTWN 750
    GEHANREFGK MGKSLKNIVT PDYMYENYGA DTFRLYEMSM GPLDESRPWN 800
    TRNVVGGMRF LQRLWRNVVD ETTGQAHVTE DTPDEKTLKL LNNTIAEVTA 850
    EMEGMRPNTA IAKLIVLNNH LTGLKAVPRA AVEPLILMLA PIAPHICEEM 900
    WSKLGHAESL SAEPWPVADE RYVGHDTVTA VVQIKGKVRA KLEVPVDIDP 950
    ADLEKQALAA VADRLGGKEP RKVIVKAPKI VSIVPAE 987
    Length:987
    Mass (Da):110,295
    Last modified:March 1, 2003 - v1
    Checksum:iA5EADD58993F6EA8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014295 Genomic DNA. Translation: AAN25245.1.
    RefSeqiNP_696609.1. NC_004307.2.

    Genome annotation databases

    EnsemblBacteriaiAAN25245; AAN25245; BL1450.
    GeneIDi1021602.
    KEGGiblo:BL1450.
    PATRICi21117653. VBIBifLon107831_0308.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014295 Genomic DNA. Translation: AAN25245.1 .
    RefSeqi NP_696609.1. NC_004307.2.

    3D structure databases

    ProteinModelPortali Q8G4D8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 206672.BL1450.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN25245 ; AAN25245 ; BL1450 .
    GeneIDi 1021602.
    KEGGi blo:BL1450.
    PATRICi 21117653. VBIBifLon107831_0308.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi YARYHRM.
    OrthoDBi EOG63Z74X.
    PhylomeDBi Q8G4D8.

    Enzyme and pathway databases

    BioCyci BLON206672:GI1E-287-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
      Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
      Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCC 2705.

    Entry informationi

    Entry nameiSYL_BIFLO
    AccessioniPrimary (citable) accession number: Q8G4D8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3