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Q8G490

- Q8G490_BIFLO

UniProt

Q8G490 - Q8G490_BIFLO

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd1

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADPUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei212 – 2121Critical for catalysisUniRule annotation
    Metal bindingi252 – 2521Magnesium or manganeseUniRule annotation
    Binding sitei260 – 2601NADPUniRule annotation
    Metal bindingi275 – 2751Magnesium or manganeseUniRule annotation
    Binding sitei328 – 3281NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADPUniRule annotation
    Nucleotide bindingi310 – 3156NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciBLON206672:GI1E-339-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icd1Imported
    Ordered Locus Names:BL1499Imported
    OrganismiBifidobacterium longum (strain NCC 2705)Imported
    Taxonomic identifieri206672 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000000439: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi206672.BL1499.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G490.
    SMRiQ8G490. Positions 3-405.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000019858.
    KOiK00031.
    OMAiFKDEFQR.
    OrthoDBiEOG628F3X.
    PhylomeDBiQ8G490.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8G490-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKIKVEGTV VELDGDEMTR VIWKDIKDRL ILPYLDVNLD YYDLGIEHRD    50
    ETDDQVTIDA AHAIQKHHVG VKCATITPDE ARVKEFGLKK MWKSPNGTIR 100
    NILGGTIFRE PIVMSNVPRL VPGWTKPIVV ARHAFGDQYK ATDFKVPGAG 150
    QLTVTFTPDD GSEPIQHVVY NYGEDGGVAQ VQYNVNDSIR GFARACFNYG 200
    LMRHYPVYLS TKNTILKAYD GQFKDIFAEV FETEYKDRYA EAGLTYEHRL 250
    IDDMVASSLK WHGGYIWACK NYDGDVQSDS VAQGFGSLGL MTSVLMTPDG 300
    QTVEAEAAHG TVTRHYRRWQ KGEKTSTNPI ASIFAWTGGL KHRADLDGTP 350
    EVRHFAKTLE KVIVDTVEGG QMTKDLAMLI GPDEPWLDTD GFMNALDENL 400
    AKALAE 406
    Length:406
    Mass (Da):45,387
    Last modified:March 1, 2003 - v1
    Checksum:iC8B169E390E8562D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014295 Genomic DNA. Translation: AAN25294.1.
    RefSeqiNP_696658.1. NC_004307.2.

    Genome annotation databases

    EnsemblBacteriaiAAN25294; AAN25294; BL1499.
    GeneIDi1021661.
    KEGGiblo:BL1499.
    PATRICi21117783. VBIBifLon107831_0370.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014295 Genomic DNA. Translation: AAN25294.1 .
    RefSeqi NP_696658.1. NC_004307.2.

    3D structure databases

    ProteinModelPortali Q8G490.
    SMRi Q8G490. Positions 3-405.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 206672.BL1499.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN25294 ; AAN25294 ; BL1499 .
    GeneIDi 1021661.
    KEGGi blo:BL1499.
    PATRICi 21117783. VBIBifLon107831_0370.

    Phylogenomic databases

    HOGENOMi HOG000019858.
    KOi K00031.
    OMAi FKDEFQR.
    OrthoDBi EOG628F3X.
    PhylomeDBi Q8G490.

    Enzyme and pathway databases

    BioCyci BLON206672:GI1E-339-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
      Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
      Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCC 2705Imported.

    Entry informationi

    Entry nameiQ8G490_BIFLO
    AccessioniPrimary (citable) accession number: Q8G490
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3