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Q8G490 (Q8G490_BIFLO) Unreviewed, UniProtKB/TrEMBL

Last modified November 13, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Name:icd1 EMBL AAN25294.1
Ordered Locus Names:BL1499 EMBL AAN25294.1
OrganismBifidobacterium longum (strain NCC 2705) [Reference proteome] [HAMAP] EMBL AAN25294.1
Taxonomic identifier206672 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding310 – 3156NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2521Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2751Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2601NADP By similarity PIRSR PIRSR000108-4
Binding site3281NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity
Site2121Critical for catalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8G490 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: C8B169E390E8562D

FASTA40645,387
        10         20         30         40         50         60 
MAKIKVEGTV VELDGDEMTR VIWKDIKDRL ILPYLDVNLD YYDLGIEHRD ETDDQVTIDA 

        70         80         90        100        110        120 
AHAIQKHHVG VKCATITPDE ARVKEFGLKK MWKSPNGTIR NILGGTIFRE PIVMSNVPRL 

       130        140        150        160        170        180 
VPGWTKPIVV ARHAFGDQYK ATDFKVPGAG QLTVTFTPDD GSEPIQHVVY NYGEDGGVAQ 

       190        200        210        220        230        240 
VQYNVNDSIR GFARACFNYG LMRHYPVYLS TKNTILKAYD GQFKDIFAEV FETEYKDRYA 

       250        260        270        280        290        300 
EAGLTYEHRL IDDMVASSLK WHGGYIWACK NYDGDVQSDS VAQGFGSLGL MTSVLMTPDG 

       310        320        330        340        350        360 
QTVEAEAAHG TVTRHYRRWQ KGEKTSTNPI ASIFAWTGGL KHRADLDGTP EVRHFAKTLE 

       370        380        390        400 
KVIVDTVEGG QMTKDLAMLI GPDEPWLDTD GFMNALDENL AKALAE 

« Hide

References

[1]"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCC 2705.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014295 Genomic DNA. Translation: AAN25294.1.
RefSeqNP_696658.1. NC_004307.2.

3D structure databases

ProteinModelPortalQ8G490.
SMRQ8G490. Positions 3-405.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING206672.BL1499.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN25294; AAN25294; BL1499.
GeneID1021661.
KEGGblo:BL1499.
PATRIC21117783. VBIBifLon107831_0370.

Phylogenomic databases

HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.
OrthoDBEOG628F3X.
ProtClustDBPRK08299.

Enzyme and pathway databases

BioCycBLON206672:GI1E-339-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ8G490_BIFLO
AccessionPrimary (citable) accession number: Q8G490
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 13, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)