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Q8G490

- Q8G490_BIFLO

UniProt

Q8G490 - Q8G490_BIFLO

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd1

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADPUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei212 – 2121Critical for catalysisUniRule annotation
Metal bindingi252 – 2521Magnesium or manganeseUniRule annotation
Binding sitei260 – 2601NADPUniRule annotation
Metal bindingi275 – 2751Magnesium or manganeseUniRule annotation
Binding sitei328 – 3281NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi310 – 3156NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBLON206672:GI1E-339-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icd1Imported
Ordered Locus Names:BL1499Imported
OrganismiBifidobacterium longum (strain NCC 2705)Imported
Taxonomic identifieri206672 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000000439: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi206672.BL1499.

Structurei

3D structure databases

ProteinModelPortaliQ8G490.
SMRiQ8G490. Positions 3-405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiFKDEFQR.
OrthoDBiEOG628F3X.
PhylomeDBiQ8G490.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G490-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKIKVEGTV VELDGDEMTR VIWKDIKDRL ILPYLDVNLD YYDLGIEHRD
60 70 80 90 100
ETDDQVTIDA AHAIQKHHVG VKCATITPDE ARVKEFGLKK MWKSPNGTIR
110 120 130 140 150
NILGGTIFRE PIVMSNVPRL VPGWTKPIVV ARHAFGDQYK ATDFKVPGAG
160 170 180 190 200
QLTVTFTPDD GSEPIQHVVY NYGEDGGVAQ VQYNVNDSIR GFARACFNYG
210 220 230 240 250
LMRHYPVYLS TKNTILKAYD GQFKDIFAEV FETEYKDRYA EAGLTYEHRL
260 270 280 290 300
IDDMVASSLK WHGGYIWACK NYDGDVQSDS VAQGFGSLGL MTSVLMTPDG
310 320 330 340 350
QTVEAEAAHG TVTRHYRRWQ KGEKTSTNPI ASIFAWTGGL KHRADLDGTP
360 370 380 390 400
EVRHFAKTLE KVIVDTVEGG QMTKDLAMLI GPDEPWLDTD GFMNALDENL

AKALAE
Length:406
Mass (Da):45,387
Last modified:March 1, 2003 - v1
Checksum:iC8B169E390E8562D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014295 Genomic DNA. Translation: AAN25294.1.
RefSeqiNP_696658.1. NC_004307.2.

Genome annotation databases

EnsemblBacteriaiAAN25294; AAN25294; BL1499.
GeneIDi1021661.
KEGGiblo:BL1499.
PATRICi21117783. VBIBifLon107831_0370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014295 Genomic DNA. Translation: AAN25294.1 .
RefSeqi NP_696658.1. NC_004307.2.

3D structure databases

ProteinModelPortali Q8G490.
SMRi Q8G490. Positions 3-405.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 206672.BL1499.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN25294 ; AAN25294 ; BL1499 .
GeneIDi 1021661.
KEGGi blo:BL1499.
PATRICi 21117783. VBIBifLon107831_0370.

Phylogenomic databases

HOGENOMi HOG000019858.
KOi K00031.
OMAi FKDEFQR.
OrthoDBi EOG628F3X.
PhylomeDBi Q8G490.

Enzyme and pathway databases

BioCyci BLON206672:GI1E-339-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
    Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
    Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCC 2705Imported.

Entry informationi

Entry nameiQ8G490_BIFLO
AccessioniPrimary (citable) accession number: Q8G490
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3