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Q8G487

- DEF2_BIFLO

UniProt

Q8G487 - DEF2_BIFLO

Protein

Peptide deformylase 2

Gene

def2

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi88 – 881IronUniRule annotation
    Metal bindingi130 – 1301IronUniRule annotation
    Active sitei131 – 1311UniRule annotation
    Metal bindingi134 – 1341IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciBLON206672:GI1E-342-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylase 2UniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDF 2UniRule annotation
    Alternative name(s):
    Polypeptide deformylase 2UniRule annotation
    Gene namesi
    Name:def2UniRule annotation
    Ordered Locus Names:BL1502
    OrganismiBifidobacterium longum (strain NCC 2705)
    Taxonomic identifieri206672 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000000439: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 162162Peptide deformylase 2PRO_0000082743Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi206672.BL1502.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G487.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243508.
    KOiK01462.
    OMAiYVINPRI.
    OrthoDBiEOG664CMF.
    PhylomeDBiQ8G487.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8G487-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIREIRVVP DPVLRTPCDE IKEITPAVRR LVDDLLETVD DPGRAGLSAN    50
    QIGVSLRAFS YNIDGKVGYV LNPVLEEKSG EQYGDEGCLS VPGLWYKTRR 100
    ADYARVRGID LDGNEVVLEG SGLMGRMLQH ECDHLDGHVY LDRLEKEERR 150
    EALRYMRNRQ AK 162
    Length:162
    Mass (Da):18,369
    Last modified:March 1, 2003 - v1
    Checksum:i932A148E88547D53
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014295 Genomic DNA. Translation: AAN25297.1.
    RefSeqiNP_696661.1. NC_004307.2.

    Genome annotation databases

    EnsemblBacteriaiAAN25297; AAN25297; BL1502.
    GeneIDi1021664.
    KEGGiblo:BL1502.
    PATRICi21117791. VBIBifLon107831_0374.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014295 Genomic DNA. Translation: AAN25297.1 .
    RefSeqi NP_696661.1. NC_004307.2.

    3D structure databases

    ProteinModelPortali Q8G487.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 206672.BL1502.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN25297 ; AAN25297 ; BL1502 .
    GeneIDi 1021664.
    KEGGi blo:BL1502.
    PATRICi 21117791. VBIBifLon107831_0374.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243508.
    KOi K01462.
    OMAi YVINPRI.
    OrthoDBi EOG664CMF.
    PhylomeDBi Q8G487.

    Enzyme and pathway databases

    BioCyci BLON206672:GI1E-342-MONOMER.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
      Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
      Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCC 2705.

    Entry informationi

    Entry nameiDEF2_BIFLO
    AccessioniPrimary (citable) accession number: Q8G487
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3