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Q8G3T9

- TYSY_BIFLO

UniProt

Q8G3T9 - TYSY_BIFLO

Protein

Thymidylate synthase

Gene

thyA

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei149 – 1491UniRule annotation

    GO - Molecular functioni

    1. thymidylate synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTMP biosynthetic process Source: UniProtKB-HAMAP
    2. dTTP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciBLON206672:GI1E-1648-MONOMER.
    UniPathwayiUPA00575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
    Short name:
    TSUniRule annotation
    Short name:
    TSaseUniRule annotation
    Gene namesi
    Name:thyAUniRule annotation
    Ordered Locus Names:BL1665
    OrganismiBifidobacterium longum (strain NCC 2705)
    Taxonomic identifieri206672 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000000439: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Thymidylate synthasePRO_0000140937Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi206672.BL1665.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G3T9.
    SMRiQ8G3T9. Positions 3-266.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0207.
    HOGENOMiHOG000257899.
    KOiK00560.
    OMAiTEIDAFT.
    OrthoDBiEOG6K6V53.
    PhylomeDBiQ8G3T9.

    Family and domain databases

    Gene3Di3.30.572.10. 1 hit.
    HAMAPiMF_00008. Thymidy_synth_bact.
    InterProiIPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view]
    PfamiPF00303. Thymidylat_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00108. THYMDSNTHASE.
    SUPFAMiSSF55831. SSF55831. 1 hit.
    TIGRFAMsiTIGR03284. thym_sym. 2 hits.
    PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8G3T9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPYEDLVRKI LTEGTLKSDR TGTGTISLFG QQMRFDLSKY FPLLTTKTVF    50
    FKGLAYELLW FLKGSSNINW LLEHNVHIWD EWADENGDLG PVYGVQWRSW 100
    PAPTPEDPNR TIDQISNVLD LIKHHPDSRR MIVSAWNPAE VEKMALPPCH 150
    ALFQFYVADD KLSCQLYQRS CDMFLGVPFN IASYSLLTMM MAQQAGLKPG 200
    EFVWTGGDCH VYDNHVDQFL EQLGRKPYPY PTIEIRKADS LFDYQYEDFK 250
    VVGYQHHPTI KAPVAV 266
    Length:266
    Mass (Da):30,689
    Last modified:March 1, 2003 - v1
    Checksum:iE8BDC2C4B8B9DE70
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014295 Genomic DNA. Translation: AAN25452.1.
    RefSeqiNP_696816.1. NC_004307.2.

    Genome annotation databases

    EnsemblBacteriaiAAN25452; AAN25452; BL1665.
    GeneIDi1021894.
    KEGGiblo:BL1665.
    PATRICi21120592. VBIBifLon107831_1720.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014295 Genomic DNA. Translation: AAN25452.1 .
    RefSeqi NP_696816.1. NC_004307.2.

    3D structure databases

    ProteinModelPortali Q8G3T9.
    SMRi Q8G3T9. Positions 3-266.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 206672.BL1665.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN25452 ; AAN25452 ; BL1665 .
    GeneIDi 1021894.
    KEGGi blo:BL1665.
    PATRICi 21120592. VBIBifLon107831_1720.

    Phylogenomic databases

    eggNOGi COG0207.
    HOGENOMi HOG000257899.
    KOi K00560.
    OMAi TEIDAFT.
    OrthoDBi EOG6K6V53.
    PhylomeDBi Q8G3T9.

    Enzyme and pathway databases

    UniPathwayi UPA00575 .
    BioCyci BLON206672:GI1E-1648-MONOMER.

    Family and domain databases

    Gene3Di 3.30.572.10. 1 hit.
    HAMAPi MF_00008. Thymidy_synth_bact.
    InterProi IPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view ]
    Pfami PF00303. Thymidylat_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00108. THYMDSNTHASE.
    SUPFAMi SSF55831. SSF55831. 1 hit.
    TIGRFAMsi TIGR03284. thym_sym. 2 hits.
    PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
      Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
      Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCC 2705.

    Entry informationi

    Entry nameiTYSY_BIFLO
    AccessioniPrimary (citable) accession number: Q8G3T9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3